Toxicology PhD Research Projects PhD Projects, Programmes & Scholarships

We have 51 Toxicology PhD Research Projects PhD Projects, Programmes & Scholarships

Development of Naked Mole Rat Colonic Crypt Models to Use in the Search for Bowel Disease Preventatives

University of Bradford Faculty of Life Sciences

Research Group: Institute of Cancer Therapeutics

Diseases affecting the bowel such as colorectal cancer (CRC) and the inflammatory bowel diseases (IBD) ulcerative colitis and Crohn’s disease are major global healthcare challenges in the 21st century. Read more

Supervisors: Dr S Shnyder, Prof S El-Khamisy

Year round applications PhD Research Project Self-Funded PhD Students Only

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Development of a personalized therapy for pulmonary arterial hypertension (PAH)

University of Bradford Faculty of Life Sciences

Research Group: Pharmacology and Experimental Therapeutics

Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death. Read more

Supervisor: Dr T Nasim

Year round applications PhD Research Project Self-Funded PhD Students Only

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Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

University of Bradford Faculty of Life Sciences

Research Group: Institute of Cancer Therapeutics

Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more

Supervisors: Prof R Falconer, Prof P Loadman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents

University of Bradford Faculty of Life Sciences

Research Group: Institute of Cancer Therapeutics

Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more

Supervisors: Prof R Falconer, Dr S Shnyder

Year round applications PhD Research Project Self-Funded PhD Students Only

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Re-purposing established drugs for the resolution of pulmonary arterial hypertension (PAH)

University of Bradford Faculty of Life Sciences

Research Group: Pharmacology and Experimental Therapeutics

Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death. Read more

Supervisors: Dr T Nasim, Dr K Assi

Year round applications PhD Research Project Self-Funded PhD Students Only

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Engineered nanomaterials for safe sustainable water purification

University of Liverpool School of Engineering

Access to clean drinking water and sanitation has seen substantial progress in recent time, however there is still a large part of the global population, that live mostly in rural settings, that lack this basic necessity. Read more

Supervisor: Prof RA D'Sa

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding mechanisms leading to the formation of plastic degradation products by the action of UV-B using advanced analytical techniques.

Kingston University Faculty of Health, Science, Social Care and Education

Plastic production is on the rise and pollution derived from it is increasing. The scientific community is trying to understand how plastic degrades and fragments into micro, nanoplastics and chemical degradation products. Read more

Supervisor: Dr R Busquets

Year round applications PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Hepatic Models to personalise cancer chemotherapy

University of Liverpool Department of Pharmacology and Therapeutics

The most commonly used chemotherapy regimens for colorectal cancer with liver metastases are oxaliplatin combined with 5-FU and leucovorin, i.e. Read more

Supervisors: Prof C Goldring, Dr A Chadwick, Prof IC Copple, Dr S Pushpakom

Year round applications PhD Research Project Self-Funded PhD Students Only

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The epigenomic, transcriptional and diagnostic architecture of neurodevelopmental disorders caused by exposure to maternal infection

The University of Manchester Faculty of Biology, Medicine and Health

A fundamental unknown in understanding mechanisms of disease, and therefore improving therapy, is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult disease (Estes & McAllister 2016). Read more

Supervisors: Dr R Hager, Dr M Harte, Dr J Glazier

Year round applications PhD Research Project Self-Funded PhD Students Only

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Analysis of the role of liver sinusoidal endothelial cells in methotrexate-induced liver toxicity

University of Liverpool Department of Pharmacology and Therapeutics

Liver sinusoidal endothelial cells (LSECs) comprise approximately 50% of the non-parenchymal hepatic cells. They play a vital role in hepatic microcirculation and provide a physiological barrier to the movement of xenobiotics from the bloodstream to hepatic tissue. Read more

Supervisors: Dr M Cross, Prof C Goldring

Year round applications PhD Research Project Self-Funded PhD Students Only

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Personalising cancer treatment with tumour evolution modelling using AI-based genomics biomarkers and PK/PD

University of Liverpool Institute of Systems, Molecular and Integrative Biology

Tumour heterogeneity is a major problem limiting the efficacy of targeted oncological therapies. Most advanced tumours eventually become resistant to the treatments, ultimately making the patient succumb to metastatic disease. Read more

Supervisor: Dr T You

1 August 2024 PhD Research Project Self-Funded PhD Students Only

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Network-based predictive modelling of cardiovascular disease risk

University of Liverpool Institute of Systems, Molecular and Integrative Biology

The risk of cardiovascular disease (CVD) is orchestrated by multiple factors. QRISK models (currently QRISK3) have been used in the UK to estimate CVD risk within the next 10 years for individuals without CVD. Read more

Supervisor: Dr T You

Year round applications PhD Research Project Self-Funded PhD Students Only

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Inducing ferroptotic death to kill cancer cells

The University of Manchester Faculty of Biology, Medicine and Health

Ferroptosis is an iron-dependent form of regulated necrotic cell death triggered by oxidative degradation of lipids in membrane bilayers and subsequent irreparable damages to the plasma membrane (1). Read more

Supervisors: Dr C Tournier, Dr K Finegan

Year round applications PhD Research Project Self-Funded PhD Students Only

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Exploring the relationship between alcohol consumption and self-harm combining epidemiological and human laboratory methods

University of Bristol Bristol Medical School

Project Background. Self-harm is a major public health concern. It is the strongest predictor of suicide and is particularly common among young people; a group in which rates of self -harm and suicide appear to be rising. Read more

Supervisors: Dr B Mars, Dr J Heron, Assoc Prof AA Attwood, Prof M Munafo

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Interaction between innate immune activation and endothelial cells, linked to adverse cardiovascular events

University of Liverpool Institute of Systems, Molecular and Integrative Biology

The complement system is a key component of the immune response. Maintaining a balance between activation and inhibition of the complement system is key to preserving tissue homeostasis and enabling immune surveillance. Read more

Supervisors: Dr N Liptrott, Dr R Rainbow, Prof C Dart

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 51 Toxicology PhD Research Projects PhD Projects, Programmes & Scholarships

Toxicology PhD Research Projects PhD Projects, Programmes & Scholarships

We have 51 Toxicology PhD Research Projects PhD Projects, Programmes & Scholarships

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