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We have 26 Immunology (gene expression) PhD Projects, Programmes & Scholarships

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Immunology (gene expression) PhD Projects, Programmes & Scholarships

We have 26 Immunology (gene expression) PhD Projects, Programmes & Scholarships

Manipulation of neuroimmune responses and behaviour by infectious agents

This project is available exclusively to self-funded students who wish to commence study for a PhD in the academic year 2023/24. The project focuses on how infectious agents modify the individuals that they infect and how neuroimmune responses to infection moderate behaviour changes in warm-blooded animals and humans. Read more

The epigenomic, transcriptional and diagnostic architecture of neurodevelopmental disorders caused by exposure to maternal infection

A fundamental unknown in understanding mechanisms of disease, and therefore improving therapy, is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult disease (Estes & McAllister 2016). Read more

NIHR Leeds BRC: An interferon diagnostic to inform early detection and prevention strategies in Ana positive CTDs

Type I interferons (IFN) play a role in a wide range of rheumatic and musculoskeletal diseases (RMDs), and strong evidence suggests that measurement of IFN activity could have clinical value, although testing has not progressed into clinical settings. Read more

SLS SF1: Investigating the basis of invasive multi-drug resistant Salmonella Dublin

Salmonella Dublin belongs to non-typhoidal Salmonella that primarily causes self-limiting gastrointestinal illness in humans; however, it has adapted to cause invasive disease and life-threatening infections, especially in elderly people, children, and immunocompromised individuals. Read more

Helminth products as macrophage “trainers”: a novel tool to induce anti-inflammatory trained immunity

The innate immune system can display characteristics of immunological memory. This phenomenon, termed “trained immunity”, refers to the long-term functional reprogramming of innate immune cells after the encounter with infectious or non-infectious agents that influences their capacity to respond to a secondary stimulus. Read more

Investigating the role of P2X7 receptor intracellular domains in cell signalling

Project description. P2X7 receptors are ion channels that are found on the surface of immune cells, where they respond to the binding of extracellular ATP, a damage signal released by dying cells in infection and injury. Read more

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