We have 29 Genetics PhD Research Projects PhD Projects, Programmes & Scholarships in Bristol

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Genetics PhD Research Projects PhD Projects, Programmes & Scholarships in Bristol

We have 29 Genetics PhD Research Projects PhD Projects, Programmes & Scholarships in Bristol

Harnessing the genetics of DNA methylation to understand context-specific gene regulation in disease

University of Bristol Bristol Medical School

Genome wide association studies (GWAS) have discovered many genetic associations for traits and diseases. However, most GWAS signals reside in non-coding regions (outside genes), and it is likely that GWAS variants confer their effects through modulating regulatory mechanism. Read more

Supervisor: Dr J Min

Year round applications PhD Research Project Self-Funded PhD Students Only

Harnessing the genetics of DNA methylation to understand context-specific gene regulation in disease

University of Bristol Bristol Medical School

Project Background. Genome wide association studies (GWAS) have discovered many genetic associations with health outcomes. However, most GWAS signals reside in non-coding regions and it is likely that GWAS variants confer their effects through a regulatory mechanism. Read more

Supervisors: Dr J Min, Dr E Hannon, Prof J MIll, Dr GL Leyden

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

The genetics of human scarring – cross-cutting approaches to the understanding of human wound repair.

University of Bristol Bristol Medical School

Rationale. Repair of adult tissues involves a complex interplay of several key cell lineages and inevitably leads to formation of a fibrotic collagenous scar. Read more

Supervisors: Prof N Timpson, Prof P Martin

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Harnessing genetics of DNA methylation to elucidate molecular mechanisms underlying human phenotypes.

University of Bristol Bristol Medical School

Rationale. GWAS studies have discovered many genetic associations for traits and diseases, but it has been difficult to elucidate the functional consequences of these variants. Read more

Supervisors: Dr J Min, Prof C Relton, Prof J MIll, Dr E Hannon, Dr G Hemani, Prof T Gaunt, Dr B Heijmans, Dr J Bell

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Understanding psychiatric outcomes in children born with cleft lip and/or palate using genetics

University of Bristol Bristol Medical School

Rationale. Cleft of the lip and/or palate is a common birth defect worldwide and occurs at a rate of one in 650 live births in the UK. Read more

Supervisors: Dr E Stergiakouli, Dr S Lewis, Prof M J Owen, Dr M van den Bree

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Younger, happier and more productive plants: using developmental genetics to improve herb yields and quality

University of Bristol School of Biological Sciences

If you’ve ever grown coriander at home you’ll have noticed that once the plant flowers it no longer produces the leaves used for seasoning. Read more

Supervisor: Dr J Fouracre

Year round applications PhD Research Project Self-Funded PhD Students Only

Funded PhD - Determining the genetic and circadian basis of bipolar disorder

University of Bristol School of Physiology, Pharmacology & Neuroscience

This project will be part of the University of Bristol - University of Kent Cotutelle Programme. It will be jointly supervised by Prof James Hodge (http://www.bristol.ac.uk/phys-pharm-neuro/people-new/hodge/) and Dr Alice French at the University of Bristol, and by Prof Gurprit Lall at University of Kent. Read more

Supervisors: Prof J Hodge, Dr AF French

12 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

The genetic map of human molecular phenotypes

University of Bristol Bristol Medical School

Rationale. Genome wide associations studies (GWASs) have discovered many genetic associations with a large range of human traits, but the functional consequences of GWAS signals often remain elusive, as most GWAS signals reside in non-coding genomic regions. Read more

Supervisors: Dr J Min, Dr G Hemani, Dr JH Hawe

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

An investigation of the causal relationship and genetic overlap between sleep traits and physical and mental health using Mendelian randomization

University of Bristol Bristol Medical School

Rationale. Sleep has long been known to play a role in physical and mental wellbeing and sleep disruption has been observed to co-occur with a number of health conditions including. Read more

Supervisors: Dr S Lewis, Dr MR Renteria, Dr HJ Jones

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Identifying causal pathways to disease using DNA methylation predicted blood traits.

University of Bristol Bristol Medical School

Project Background. Blood cell types have been implicated in pathogenesis of chronic diseases. Genome wide association studies have identified thousands of variants associated with blood trait variation. Read more

Supervisors: Dr J Min, Dr E Hannon, Prof J MIll

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Discovering off-target side-effects and drug repurposing candidates using expression perturbation data

University of Bristol Bristol Medical School

The MRC Integrative Epidemiology Unit at the University of Bristol is the leading group for the development and application of causal analysis and evidence triangulation in health research to improve lives. Read more

Supervisor: Prof T Gaunt

20 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

Funded PhD - The mechanisms of cognition in bees and flies

University of Bristol School of Physiology, Pharmacology & Neuroscience

This project will be part of the Bristol-Macquarie Cotutelle Programme, funded by EPSRC. Read more

Supervisor: Prof J Hodge

1 August 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

MScR - Determining the genetic and circadian basis of bipolar disorder using Drosophila

University of Bristol School of Physiology, Pharmacology & Neuroscience

Circadian rhythms and sleep are evolutionarily conserved from fruit flies (Drosophila) and are fundamental as well as vital to biology and health (Jagannath et al., 2017; Menet and Rosbash, 2011). Read more

Supervisor: Prof J Hodge

Year round applications PhD Research Project Self-Funded PhD Students Only

MScR - In vivo characterisation of novel risk genes for Alzheimers disease identified by Genome Wide Association Studies

University of Bristol School of Physiology, Pharmacology & Neuroscience

Genome Wide Association Studies (GWAS) for Alzheimer’s disease (AD) have identified a number of genes that are significantly associated with the disease (van der Kant et al., 2019). Read more

Supervisor: Prof J Hodge

Year round applications PhD Research Project Self-Funded PhD Students Only

Endothelial glycocalyx damage as a therapeutic target in sepsis-associated Acute Kidney Injury

University of Bristol Bristol Medical School

Sepsis is the leading cause of acute kidney injury (sAKI), associated with high morbidity and mortality.1,2 Unfortunately, there is no treatment for sAKI, current therapies are nonspecific and supportive of the vital organ systems in the hope the kidney will recover. Read more

Supervisor: Prof S Satchell

Year round applications PhD Research Project Self-Funded PhD Students Only

Estimating the global cancer burden due to low levels of physical activity

University of Bristol Bristol Medical School

Rationale. Around 40% of all cancers are thought to be avoidable by modification of lifestyle factors. Obesity has been found to be a risk factor for several cancers and was estimated to have caused around 3.6% of all new cancers which occurred in 2012. Read more

Supervisors: Dr S Lewis, Prof R Martin, Dr R Pulsford, Prof R Jago, Dr FB Bray

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Prospectively mapping the development of liver disease amongst young adults. Who is developing it early and why?

University of Bristol Bristol Medical School

Rationale. Historically, cirrhosis (irreversible liver scarring), often due to alcohol-related liver disease (ARLD) and non-alcoholic fatty liver disease (NAFLD), presents in the 5th and 6th decade. Read more

Supervisors: Dr KA Abeysekera, Prof M Hickman, Prof N Timpson

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

How does parental education increase risk to ADHD in the offspring?

University of Bristol Bristol Medical School

Rationale. Attention Deficit Hyperactivity Disorder (ADHD) is a chronic neurodevelopmental condition, characterised by persistent difficulties in the areas of attention span/impulse control. Read more

Supervisors: Dr E Stergiakouli, Dr L Howe, Dr AH Havdhal

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Identifying DNA methylation signatures of prostate cancer progression and mortality among patients with clinically confirmed, localised disease at baseline in a large prospective clinical trial

University of Bristol Bristol Medical School

Rationale. Prostate Cancer (PCa) is a leading cause of male mortality, with 336,000 deaths worldwide each year (1). Although most PCa cases are indolent, slow-growing, and tend not to progress, a subset of PCa cases are more aggressive and will progress to metastases, treatment resistance and death. Read more

Supervisors: Dr P Yousefi, Prof R Martin, Dr M Suderman, Dr A Lane, Dr SM Merriel

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Investigating the genetic architecture of orofacial cleft: A genome-wide association study using trio data and an investigation of parent of origin and mother-children interaction effects.

University of Bristol Bristol Medical School

Rationale. Orofacial clefts (OFCs) are the most prevalent craniofacial congenital disabilities globally, occurring at a frequency of 1 out of 700 newborns. Read more

Supervisors: Dr S Lewis, Dr E Stergiakouli, Prof H Cordell

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Identifying causal risk factors for disease progression

University of Bristol Bristol Medical School

Rationale. Typical epidemiological studies aim to identify causal risk factors for onset of disease by comparing diseased cases with disease free controls. Read more

Supervisors: Dr L Paternoster, Prof G Davey-Smith, Dr A Hartley

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Linking multivariable Mendelian randomization with lifecourse epidemiology: developing the methodology and application to a contemporary exemplar

University of Bristol Bristol Medical School

Rationale. Mendelian randomization (MR) uses genetic variants as instrumental variables to estimate the causal effect of an exposure on an outcome, free from bias due to unobserved confounding. Read more

Supervisors: Dr E Sanderson, Prof K Tilling, Prof G Davey-Smith

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Investigating causal effects of neurodevelopmental and mental health problems in childhood on adult physical health

University of Bristol Bristol Medical School

Rationale. Neurodevelopmental and mental health problems in childhood have been linked to adverse physical health outcomes in both childhood and adult life. Read more

Supervisors: Dr E Stergiakouli, Dr L Howe, Dr RB Blakey, Ms CD Dardani

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Identifying metabolic drivers of cancer development

University of Bristol Bristol Medical School

Rationale. Growing evidence suggests that cell extrinsic factors are key in modulating tumor progression. Metabolites are small molecules that act as sources of fuel and building blocks essential for cells and tissues when present at normal levels. Read more

Supervisors: Dr E Vincent, Dr CB Bull, Prof N Timpson

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Mendelian Randomisation for mediation analysis with multiple mediators: theory and applications

University of Bristol Bristol Medical School

Rationale. Many of an individual’s traits are observationally associated with their health outcomes. Understanding the relationships between these factors is critical to effective public health intervention. Read more

Supervisors: Dr E Sanderson, Dr R Daniel, Dr L Howe

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Prenatal and pre-conception effects on neurodevelopmental disorders.

University of Bristol Bristol Medical School

Rationale. There is growing concern that paternal exposures before conception have been greatly neglected. Studying how these impact on future generations’ health could open new avenues for prevention-prospective fathers are not generally advised to change their behaviour. Read more

Supervisors: Dr L Zuccolo, Dr G Sharp, Dr D Caramaschi, Prof A Thapar

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Evaluating the role of circulating proteins in cancer risk and progression using genetic and observational approaches

University of Bristol Bristol Medical School

Rationale. Circulating proteins play fundamental roles in biology and disease aetiology, including development of cancer, and are the direct targets of many drugs (1). Read more

Supervisors: Prof R Martin, Dr JY Yarmolinsky, Dr P Haycock

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Establishing and orienting causal relationships between sleep characteristics and reproductive function

University of Bristol Bristol Medical School

Rationale. A large body of literature from animal studies has highlighted the role of core clock genes in relation to reproductive function [1]. Read more

Supervisors: Dr R Richmond, Dr G Sharp, Prof D Lawlor

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

The use of life course epidemiology to support the experimental characterisation of genetic variation

University of Bristol Bristol Medical School

Project Background. There has been a rapid expansion in the generation of genetic sequence data over the last decade. Understanding the potential relevance of genetic mutations to human health remains challenging. Read more

Supervisors: Prof N Timpson, Dr L Corbin, Dr BL Lam

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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