The University of Manchester Genetics PhD Research Projects PhD Projects, Programmes & Scholarships

We have 19 The University of Manchester Genetics PhD Research Projects PhD Projects, Programmes & Scholarships

(BRC) Nailfold capillary imaging in the idiopathic inflammatory myopathies (Non-Clinical)

The University of Manchester Faculty of Biology, Medicine and Health

The idiopathic inflammatory myopathies (IIMs) are rare conditions characterised by distinct clinical subtypes and varied multisystem involvement. Read more

Supervisors: Dr A Murray, Dr H Chinoy, Dr J Lamb

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Understanding the evolution of gene regulatory networks through biophysical modelling and machine learning

The University of Manchester Faculty of Biology, Medicine and Health

The ability to coordinate the expression of genes within a cell is at the heart of life. When and how much of a specific gene is turned into a protein is essential for organisms to respond to their environment and to manage resources. Read more

Supervisors: Dr M Lagator, Prof M Rattray

Year round applications PhD Research Project Self-Funded PhD Students Only

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Delineating the IRF6 regulatory network driving periderm formation and function

The University of Manchester Faculty of Biology, Medicine and Health

During development, the ectoderm passes through a series of cell states to produce a self-replenishing, multi-layered epidermis. Initial stratification forms a single-cell layer of flattened periderm cells which act as a barrier to prevent pathological adhesions during embryogenesis. Read more

Supervisors: Prof M Dixon, Dr J Dixon

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identifying variants impacting splicing of 5’ and 3’ UTRs and underpinning inherited retinal disease

The University of Manchester Faculty of Biology, Medicine and Health

Genomic variation that impacts splicing is well established as a cause of genomic disorders, but is almost exclusively limited to protein-coding exons and introns intersecting protein-coding exons. Read more

Supervisors: Dr J Ellingford, Prof R O'Keefe

15 June 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Determining the biological basis of observed clinical outcomes in juvenile idiopathic arthritis using genetics and multiomics

The University of Manchester Faculty of Biology, Medicine and Health

Juvenile idiopathic arthritis (JIA) is a chronic inflammatory arthritis affecting children and young people with an age of disease onset less than 16 years of age. Read more

Supervisors: Dr J Bowes, Dr J Humphreys

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding the role of spliceosome gene mutations in disease

The University of Manchester Faculty of Biology, Medicine and Health

The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made. Read more

Supervisors: Prof R O'Keefe, Prof B Newman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Application of machine learning algorithms to medical images and clinical/DNA data

The University of Manchester Department of Electronic and Electrical Engineering

This project will develop an automated classifier or the estimation of prognosis of the illness using medical images of the human body, clinical data, and gene information. Read more

Supervisor: Dr F Costen

Year round applications PhD Research Project Self-Funded PhD Students Only

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Genotypic and phenotypic markers of resistance in Aspergillus fumigatus and their impact on outcomes in chronic pulmonary aspergillosis

The University of Manchester Faculty of Biology, Medicine and Health

Chronic pulmonary aspergillosis (CPA) is a progressive infection affecting patients with chronic lung disease. It significantly affects quality of life and mortality. Read more

Supervisors: Dr CK Kosmidis, Dr M Bromley, Dr R Richardson, Dr M Bottery, Prof T Hussell

Year round applications PhD Research Project Self-Funded PhD Students Only

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What is the interrelationship between cell mitosis and cell polarity during apical-basal polarisation of epithelial organs?

The University of Manchester Faculty of Biology, Medicine and Health

My group strives to uncover how mechanics and biochemical signalling work together to shape epithelial organs during development. Read more

Supervisors: Dr C.B Buckley, Dr S Woolner

Year round applications PhD Research Project Self-Funded PhD Students Only

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Hungry tissues: Understanding how energy metabolism fuels morphogenesis

The University of Manchester Faculty of Biology, Medicine and Health

A vital aspect of multi-cellular life is morphogenesis, the process where the shape and size of an animal emerges from its constituent cells. Read more

Supervisors: Dr J.R.D Davis, Dr T Millard, Dr S Woolner, Prof E Amaya

Year round applications PhD Research Project Self-Funded PhD Students Only

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The impact of nutritional scavenging on host-pathogen interactions, antifungal efficacy and emergence of antifungal resistance

The University of Manchester Faculty of Biology, Medicine and Health

Infections caused by Aspergillus fumigatus (Af) cause more deaths globally than any other fungal disease. Over 20 million are affected annually with four million having life threatening invasive and chronic infections with high morbidity and mortality up to 90%. Read more

Supervisors: Dr N.V.R Van Rhijn, Dr M Bromley

Year round applications PhD Research Project Self-Funded PhD Students Only

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A deep-learning approach to genomic regulation of tissue-specific alternative splicing

The University of Manchester Faculty of Biology, Medicine and Health

Each human gene is a blueprint for multiple distinct RNA transcripts that can be produced in differing quantities based on the localisation of the transcribing… Read more

Supervisors: Dr JE Eales, Prof T Papamarkou

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding Spinal Cord Regeneration: The role of dynamic gene expression

The University of Manchester Faculty of Biology, Medicine and Health

Spinal cord injury(SCI) paralysis is a devastating disease that affects at least 2500 people per year in the UK. It carries substantial individual and societal costs with most SCI sufferers experiencing chronic pain. Read more

Supervisors: Dr X Soto Rodriguez, Dr K Dorey, Dr Cerys Manning

Year round applications PhD Research Project Self-Funded PhD Students Only

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Chaperones and the response to protein misfolding stress

The University of Manchester Faculty of Biology, Medicine and Health

Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more

Supervisors: Prof C M Grant, Prof M Ashe

Year round applications PhD Research Project Self-Funded PhD Students Only

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Metals and host-pathogen interactions: the role of metal handling systems in the human gastrointestinal pathogen Campylobacter jejuni

The University of Manchester Faculty of Biology, Medicine and Health

Campylobacter jejuni is a globally important food-borne pathogen causing an estimated 400-500 million cases of acute human gastroenteritis each year. Read more

Supervisors: Dr J Cavet, Dr D Linton

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 19 The University of Manchester Genetics PhD Research Projects PhD Projects, Programmes & Scholarships

The University of Manchester Genetics PhD Research Projects PhD Projects, Programmes & Scholarships

We have 19 The University of Manchester Genetics PhD Research Projects PhD Projects, Programmes & Scholarships

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