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Genetics (cells) PhD Projects, Programmes & Scholarships

We have 95 Genetics (cells) PhD Projects, Programmes & Scholarships

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Role of mechanical signals in a 3D human model of alveolar differentiation

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships
Alveolar epithelial type I (AT1) and type II (AT2) cells are essential for normal lung function following birth. Abnormal differentiation of AT1 and AT2 cells during development results in pulmonary pathology with associated neonatal mortality and long-term morbidity. Read more
 Supervisors: Dr S Loukogeorgakis, Dr F Michielin, Prof P De Coppi
 15 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Developing an ADAR-mediated RNA editing therapy for treatment of Duchenne Muscular Dystrophy

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships
Duchenne muscular dystrophy (DMD) is a severe X-linked genetic disorder affecting 1:5000 boys at birth (1). DMD is caused by mutations in Dystrophin gene, with around 10% of the cases caused by nonsense mutations (2,3). Read more
 Supervisors: Dr HZ Zhou, Dr J Meng, Prof F Muntoni
 15 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Optogenetic sculpting of next-generation organoids for disease modelling of congenital malformations including spina bifida

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships
The ability to generate human induced pluripotent stem cells (iPSC) from adult cell types has revolutionised regenerative medicine research. Read more
 Supervisors: Dr G Galea, Prof J Sowden
 15 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Eliminating Harmful Cells to Maintain Homeostatis and Prevent Tumorigenesis

Cardiff University Cardiff School of Biosciences
Hamaratoglu Lab studies cell-cell signalling in development, homeostasis and tumourigenesis. We take advantage of outstanding genetic tools in Drosophila, and use larval imaginal discs as model epithelial organs. Read more
 Supervisors: Dr F Hamaratoglu, Dr C Hogan
 8 May 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Haematology: Oncogenic mechanisms causing malignant transformation of B cells and plasma cells

University of Leeds Faculty of Medicine and Health
Cancers of B cells and plasma cells, lymphomas and multiple myeloma, can be very aggressive, and often the cancer rapidly reoccurs after standard therapy. Read more
 Supervisor: Prof U Klein
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Exploring the role of interferon stimulated genes (ISGs) in stem cells of serous ovarian cancer

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Epithelial ovarian cancer (EOC) is the leading cause of mortality in women due to gynaecological cancers. High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of patients with EOC. Read more
 Supervisors: Dr S Swaroop, Dr G Grimaldi, Dr ED Perkins
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Haematology: Oncogenic reprogramming of immune cells; novel mechanism for drug resistance in leukaemia

University of Leeds Faculty of Medicine and Health
Under pathogenic challenges, cells of the haematopoietic system become epigenetically reprogrammed and establish immune memory. Read more
 Supervisor: Dr P Laslo
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Dissecting mechanisms that control adult stem cells in health, disease, and ageing

University of Birmingham Institute of Cancer and Genomic Sciences
Research interests/description of main research theme. Read more
 Supervisors: Dr M Clarke, Prof J Frampton
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Vascularising human mini-brains in a dish

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships
Blood vessels play a pivotal role in brain development and function. They promote tissue growth and survival by supplying nutrients and oxygen to surrounding tissues, signals to progenitor populations, as well as guiding neuronal migration. Read more
 Supervisors: Dr PA Alexandre, Prof D Long
 15 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Hungry tissues: Understanding how energy metabolism fuels morphogenesis

The University of Manchester Faculty of Biology, Medicine and Health
A vital aspect of multi-cellular life is morphogenesis, the process where the shape and size of an animal emerges from its constituent cells. Read more
 Supervisors: Dr J.R.D Davis, Dr T Millard, Dr S Woolner, Prof E Amaya
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Experimental and computational Cancer PhD: Overcoming osteosarcoma chemoresistance by characterizing and targeting cellular quiescence

University College London UCL Cancer Institute
Cancer is the leading cause of death in children and the second in young adults in England and Wales. Sarcomas, tumours that originate from connective tissues (bone, muscle, fat), account for around 15% of childhood cancers. Read more
 Supervisors: Dr M Secrier, Dr L Cottone
 15 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Probing Death Decisions from Morphogen Gradient Fields

University of Liverpool Department of Molecular and Clinical Cancer Medicine
Morphogen gradient scaling is one of the hottest fields in developmental biology at the moment. Scaling is fundamental, explaining how the machinery that controls pattern formation in development (the morphogens) can adapt, so that organs of different sizes show morphological structures which are proportioned. Read more
 Supervisor: Dr MM Merino
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cancer: Investigation of accentuated mitochondrial ROS and NLRP3 inflammasome activation in cystic fibrosis and colorectal carcinoma.

University of Leeds Faculty of Medicine and Health
Cystic fibrosis (CF) is associated with an accentuated inflammatory response to bacterial lipopolysaccharides (LPS), increased resting energy expenditure and a higher than expected prevalence of gastrointestinal and other malignancies. Read more
 Supervisors: Prof D Peckham, Prof D Jayne, Dr S Savic, Miss LR Caley
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Why do cancers cells re-express meiotic SYCP1 protein?

University of Liverpool Institute of Systems, Molecular and Integrative Biology
The aim of meiosis is to generate gametes by recombining the chromosomes and reducing the genome from diploid to haploid. However, in mitosis haploid genome and recombination have catastrophic, oncogenic outcomes. Read more
 Supervisor: Dr U McClurg
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Using genome engineering and bioinformatics to understand heterochromatin and centromere function in Schizosaccharomyces pombe and in cancer cells

University of Nottingham School of Life Sciences
Centromeres are the DNA sequences on eukaryotic chromosomes that mediate accurate chromosome segregation at both mitotic and meiotic cell divisions. Read more
 Supervisors: Dr W R A Brown, Dr W Wickstead
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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