Genetics (clinical development) PhD Projects, Programmes & Scholarships

We have 38 Genetics (clinical development) PhD Projects, Programmes & Scholarships

Understanding the role of pigmentation in retinal and vision development

University of Leicester School of Psychology and Vision Sciences

Establishing structure-function correlations in vision development . The aim of this project is to develop methods to study the relationship between pigmentation and vision development in humans and zebrafish. . Read more

Supervisors: Dr M Thomas, Dr W Norton, Dr J McDearmid

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Role of mechanical signals in a 3D human model of alveolar differentiation

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

Alveolar epithelial type I (AT1) and type II (AT2) cells are essential for normal lung function following birth. Abnormal differentiation of AT1 and AT2 cells during development results in pulmonary pathology with associated neonatal mortality and long-term morbidity. Read more

Supervisors: Dr S Loukogeorgakis, Dr F Michielin, Prof P De Coppi

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Determining the biological basis of observed clinical outcomes in juvenile idiopathic arthritis using genetics and multiomics

The University of Manchester Faculty of Biology, Medicine and Health

Juvenile idiopathic arthritis (JIA) is a chronic inflammatory arthritis affecting children and young people with an age of disease onset less than 16 years of age. Read more

Supervisors: Dr J Bowes, Dr J Humphreys

Year round applications PhD Research Project Self-Funded PhD Students Only

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NIHR GOSH BRC Translational Research (Non-Clinical) PhD Studentships

Great Ormond Street Hospital for Children NHS Trust

The NIHR Great Ormond Street Hospital Biomedical Research Centre (NIHR GOSH BRC) PhD Studentship Programme aims to fund five highly motivated non-clinical PhDs students to support the training and development of the next generation of translational researchers. Read more

Funded PhD Programme (UK Students Only) PhD Opportunities

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AI-assisted diagnosis, surgical planning & implant design for craniofacial patient care

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

Craniofacial diseases, particularly in craniosynostosis cases, present significant challenges in diagnosis and treatment. Read more

Supervisors: Dr S Schievano, Prof O Jeelani

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Advancing translational cell therapy for Hirschsprung disease

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

Clinical disorders characterised by neuronal loss or dysfunction in the gastrointestinal tract remain some of the most challenging to manage, with considerable morbidity and mortality and very limited treatments. Read more

Supervisors: Dr C McCann, Prof P De Coppi

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Optogenetic sculpting of next-generation organoids for disease modelling of congenital malformations including spina bifida

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

The ability to generate human induced pluripotent stem cells (iPSC) from adult cell types has revolutionised regenerative medicine research. Read more

Supervisors: Dr G Galea, Prof J Sowden

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Using pre-clinical models of disease to define new targets to slow joint degeneration in osteoarthritis

University of Liverpool Institute of Life Course and Medical Sciences

The main overall aim of this project is to understand mechanisms of joint degeneration during osteoarthritis progression in order to define new targets for therapy. Read more

Supervisor: Dr B Poulet

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identifying DNA methylation signatures of prostate cancer progression and mortality among patients with clinically confirmed, localised disease at baseline in a large prospective clinical trial

University of Bristol Bristol Medical School

Rationale. Prostate Cancer (PCa) is a leading cause of male mortality, with 336,000 deaths worldwide each year (1). Although most PCa cases are indolent, slow-growing, and tend not to progress, a subset of PCa cases are more aggressive and will progress to metastases, treatment resistance and death. Read more

Supervisors: Dr P Yousefi, Prof R Martin, Dr M Suderman, Dr A Lane, Dr SM Merriel

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Genotypic and phenotypic markers of resistance in Aspergillus fumigatus and their impact on outcomes in chronic pulmonary aspergillosis

The University of Manchester Faculty of Biology, Medicine and Health

Chronic pulmonary aspergillosis (CPA) is a progressive infection affecting patients with chronic lung disease. It significantly affects quality of life and mortality. Read more

Supervisors: Dr CK Kosmidis, Dr M Bromley, Dr R Richardson, Dr M Bottery, Prof T Hussell

Year round applications PhD Research Project Self-Funded PhD Students Only

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Treatment and biomarker development for inherited manganese transporter defects using cell models of SLC30A10 deficiency

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

Manganese is essential to human health and development. However, excess manganese is neurotoxic causing manganism, a neurodegenerative disorder characterised by dystonia-parkinsonism. Read more

Supervisors: Dr K Tuschl, Dr P Mills, Dr WH Heywood

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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(BRC) Nailfold capillary imaging in the idiopathic inflammatory myopathies (Non-Clinical)

The University of Manchester Faculty of Biology, Medicine and Health

The idiopathic inflammatory myopathies (IIMs) are rare conditions characterised by distinct clinical subtypes and varied multisystem involvement. Read more

Supervisors: Dr A Murray, Dr H Chinoy, Dr J Lamb

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Vascularising human mini-brains in a dish

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

Blood vessels play a pivotal role in brain development and function. They promote tissue growth and survival by supplying nutrients and oxygen to surrounding tissues, signals to progenitor populations, as well as guiding neuronal migration. Read more

Supervisors: Dr PA Alexandre, Prof D Long

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Health and development outcomes and their interaction for children with chronic liver disease: a population-based cohort using novel linkage between health and education records

Great Ormond Street Hospital for Children NHS Trust GOSH BRC Applied Child Health Informatics Theme (Non-Clinical) PhD Studentships

Each year in the UK, 400 children are diagnosed with chronic liver disease (CLD), with a fifth requiring liver transplantation at some stage. Read more

Supervisors: Prof KH Harron, Dr AZ Zylbersztejn

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Multimodal Artificial Intelligence for the Detection and stratification of Necrotising Enterocolitis in premature born infants (MAIDNEC)

Great Ormond Street Hospital for Children NHS Trust GOSH BRC Applied Child Health Informatics Theme (Non-Clinical) PhD Studentships

Necrotising Enterocolitis (NEC) is a severe gastrointestinal inflammatory condition affecting neonates, most commonly premature infants although up to 25% is observed among full-term babies1. Read more

Supervisors: Dr S Eaton, Dr E Mazomenos

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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We have 38 Genetics (clinical development) PhD Projects, Programmes & Scholarships

Genetics (clinical development) PhD Projects, Programmes & Scholarships

We have 38 Genetics (clinical development) PhD Projects, Programmes & Scholarships

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