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We have 17 Genetics (drugs) PhD Projects, Programmes & Scholarships

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Genetics (drugs) PhD Projects, Programmes & Scholarships

We have 17 Genetics (drugs) PhD Projects, Programmes & Scholarships

Discovering off-target side-effects and drug repurposing candidates using expression perturbation data

The MRC Integrative Epidemiology Unit at the University of Bristol is the leading group for the development and application of causal analysis and evidence triangulation in health research to improve lives. Read more

Role of mechanical signals in a 3D human model of alveolar differentiation

Alveolar epithelial type I (AT1) and type II (AT2) cells are essential for normal lung function following birth. Abnormal differentiation of AT1 and AT2 cells during development results in pulmonary pathology with associated neonatal mortality and long-term morbidity. Read more

Funded PhD - Determining the genetic and circadian basis of bipolar disorder

This project will be part of the University of Bristol - University of Kent Cotutelle Programme. It will be jointly supervised by Prof James Hodge (http://www.bristol.ac.uk/phys-pharm-neuro/people-new/hodge/) and Dr Alice French at the University of Bristol, and by Prof Gurprit Lall at University of Kent. Read more

Using chemical-genetics to inhibit and characterise “undruggable” enzymes

The ability to inhibit kinases with small molecule drugs has transformed our understanding of signalling networks. It has allowed us to define the substrates and processes that each kinase controls, and to map how these enzymes cooperate within signalling pathways. Read more

MScR - Determining the genetic and circadian basis of bipolar disorder using Drosophila

Circadian rhythms and sleep are evolutionarily conserved from fruit flies (Drosophila) and are fundamental as well as vital to biology and health (Jagannath et al., 2017; Menet and Rosbash, 2011). Read more

MSc By Research: Understanding the mechanism of an essential nematode gene expression process

The MSc by Research programme at the University of Aberdeen is for students interested in a research-intensive master's degree. It is designed specifically to enhance your skills for a PhD or research career. Read more

Experimental and computational Cancer PhD: Overcoming osteosarcoma chemoresistance by characterizing and targeting cellular quiescence

Cancer is the leading cause of death in children and the second in young adults in England and Wales. Sarcomas, tumours that originate from connective tissues (bone, muscle, fat), account for around 15% of childhood cancers. Read more

Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation

Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more

Fully funded PhD studentship in mechanisms of cancer heterogeneity and drug sensitivity

Treatment of cancer with drugs that cause DNA damage often leads to development of the drug tolerance. Recently, we uncovered a novel mechanism of such an adaptation that associates with active generation of hundreds of thousand mutations in chromosomes that prevent drug-triggered DNA damage. Read more

Developing therapies targeting inflammation and dysfunctional matrix biology in neurological and ocular disease

We are seeking talented, motivated students with a passion for research in inflammation and matrix biology in the eye and brain to join our team co-led by Dr Lisa Hill https://www.birmingham.ac.uk/staff/profiles/clinical-sciences/hill-lisa.aspx and Dr Hannah Botfield https://www.birmingham.ac.uk/staff/profiles/inflammation-ageing/botfield-hannah.aspx. Read more

Genetics: Investigating the functional effect of novel genes and genetic variants in malignant hyperthermia susceptibility using model systems

Malignant hyperthermia (MH) is an inherited condition, where patients exposed to anaesthetic drugs are susceptible to a dramatic hyperthermic and hypermetabolic response that can contribute to a significant proportion of post-operative morbidity and deaths. Read more

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