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We have 12 Genetics (epithelial) PhD Projects, Programmes & Scholarships

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Genetics (epithelial) PhD Projects, Programmes & Scholarships

We have 12 Genetics (epithelial) PhD Projects, Programmes & Scholarships

How to build and maintain a 3-dimensional polarised epithelial sheet

We are interested in how cells maintain normal cell shape within an epithelium. Correct epithelial cell shape is essential to maintain tissue integrity and when deregulated can cause diseases such as malignant cancers, diabetes, inflammation, and aging. Read more

Role of mechanical signals in a 3D human model of alveolar differentiation

Alveolar epithelial type I (AT1) and type II (AT2) cells are essential for normal lung function following birth. Abnormal differentiation of AT1 and AT2 cells during development results in pulmonary pathology with associated neonatal mortality and long-term morbidity. Read more

Eliminating Harmful Cells to Maintain Homeostatis and Prevent Tumorigenesis

Hamaratoglu Lab studies cell-cell signalling in development, homeostasis and tumourigenesis. We take advantage of outstanding genetic tools in Drosophila, and use larval imaginal discs as model epithelial organs. Read more

Exploring the role of interferon stimulated genes (ISGs) in stem cells of serous ovarian cancer

  Research Group: Institute of Cancer Therapeutics
Epithelial ovarian cancer (EOC) is the leading cause of mortality in women due to gynaecological cancers. High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of patients with EOC. Read more

Cancer: Characterization of EGFR signaling activated by the endothelium in the process of breast cancer metastasis to the brain

The Epidermal Growth Factor Receptor (EGFR) is important in normal physiology regulating epithelial development and homeostasis. In cancer, deregulation resulting from mutation, amplification or transcriptional upregulation promotes tumorigenesis. Read more

The impact of nutritional scavenging on host-pathogen interactions, antifungal efficacy and emergence of antifungal resistance

Infections caused by Aspergillus fumigatus (Af) cause more deaths globally than any other fungal disease. Over 20 million are affected annually with four million having life threatening invasive and chronic infections with high morbidity and mortality up to 90%. Read more
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