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We have 9 Genetics (mice) PhD Projects, Programmes & Scholarships

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Genetics (mice) PhD Projects, Programmes & Scholarships

We have 9 Genetics (mice) PhD Projects, Programmes & Scholarships

Delineating the IRF6 regulatory network driving periderm formation and function

During development, the ectoderm passes through a series of cell states to produce a self-replenishing, multi-layered epidermis. Initial stratification forms a single-cell layer of flattened periderm cells which act as a barrier to prevent pathological adhesions during embryogenesis. Read more

Funded PhD - Determining the genetic and circadian basis of bipolar disorder

This project will be part of the University of Bristol - University of Kent Cotutelle Programme. It will be jointly supervised by Prof James Hodge (http://www.bristol.ac.uk/phys-pharm-neuro/people-new/hodge/) and Dr Alice French at the University of Bristol, and by Prof Gurprit Lall at University of Kent. Read more

Endothelial glycocalyx damage as a therapeutic target in sepsis-associated Acute Kidney Injury

Sepsis is the leading cause of acute kidney injury (sAKI), associated with high morbidity and mortality.1,2 Unfortunately, there is no treatment for sAKI, current therapies are nonspecific and supportive of the vital organ systems in the hope the kidney will recover. Read more

Advancing translational cell therapy for Hirschsprung disease

Clinical disorders characterised by neuronal loss or dysfunction in the gastrointestinal tract remain some of the most challenging to manage, with considerable morbidity and mortality and very limited treatments. Read more

Vascularising human mini-brains in a dish

Blood vessels play a pivotal role in brain development and function. They promote tissue growth and survival by supplying nutrients and oxygen to surrounding tissues, signals to progenitor populations, as well as guiding neuronal migration. Read more

The use of life course epidemiology to support the experimental characterisation of genetic variation

Project Background. There has been a rapid expansion in the generation of genetic sequence data over the last decade. Understanding the potential relevance of genetic mutations to human health remains challenging. Read more
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