Genetics (system) PhD Projects, Programmes & Scholarships

We have 76 Genetics (system) PhD Projects, Programmes & Scholarships

A new approach to CRISPR-Cas adaptation and the discovery of host accessory-proteins

University of Nottingham School of Life Sciences

Bacteria provide many health benefits and eco-environmental services. Although physically simple, they have a sophisticated immune system, CRISPR-Cas. Read more

Supervisors: Prof R Chalmers, Prof U Vinkemeier

Year round applications PhD Research Project Competition Funded PhD Project (UK Students Only)

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Identifying the neurogenetic network underlying visually-driven sleep

University of Leicester Department of Genetics and Genome Biology

General background. Sleep is a behavioural quiescence widely observed in the animal kingdom. During sleep, an animal’s motor activity, as well as their responsiveness to environmental stimuli, are largely reduced. Read more

Supervisors: Dr K Chen, Dr R Feuda

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Multimodal Artificial Intelligence for the Detection and stratification of Necrotising Enterocolitis in premature born infants (MAIDNEC)

Great Ormond Street Hospital for Children NHS Trust GOSH BRC Applied Child Health Informatics Theme (Non-Clinical) PhD Studentships

Necrotising Enterocolitis (NEC) is a severe gastrointestinal inflammatory condition affecting neonates, most commonly premature infants although up to 25% is observed among full-term babies1. Read more

Supervisors: Dr S Eaton, Dr E Mazomenos

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Using chemical-genetics to inhibit and characterise “undruggable” enzymes

University of Dundee School of Medicine

The ability to inhibit kinases with small molecule drugs has transformed our understanding of signalling networks. It has allowed us to define the substrates and processes that each kinase controls, and to map how these enzymes cooperate within signalling pathways. Read more

Supervisors: Dr A Saurin, Dr T Ly

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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Cardiovascular and Neuromuscular Functions around the Clock: Harnessing Protective Endogenous Mechanisms towards Smarter Design of Novel Therapies and Interventions

University of Liverpool Institute of Life Course and Medical Sciences

Optimal tissue and organ is essential for long-term health and quality of life. One such important regulator within the body is related to circadian rhythms, which control ~24h cycles in many physiological processes such as sleep/wake cycles, physical activity/rest cycles, drug metabolism and hormones. Read more

Supervisor: Dr VPV Pekovic-Vaughan

Year round applications PhD Research Project Self-Funded PhD Students Only

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Exploring the Ubiquitin-Proteasome system’s Impact on Ageing and Disease: The Interplay of Genetics, Lifestyle, and Environment

University of Reading Department of Biomedical Sciences

Project Overview. Unravelling the molecular and cellular mechanisms driving ageing to improve human health across the lifespan is a central aim of biomedical research. Read more

Supervisor: Dr E Kevei

Year round applications PhD Research Project Self-Funded PhD Students Only

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SLS SF4: Identifying pro-longevity drug targets by finding how the nervous system controls aging

University of Westminster School of Life Sciences

Our ageing society is a critical issue. Remaining healthier for longer is a priority with the burden of age-related disease. We want to identify drug targets to develop pro-longevity pharmaceuticals that preserve cognitive function later in life. Read more

Supervisors: Dr FP Partridge , Dr A Barr, Dr AA Anagnostopoulou

17 May 2024 PhD Research Project Self-Funded PhD Students Only

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MSc by Research: ADP-ribosylation in dementia and motor neuron disease

University of Dundee School of Life Sciences

ADP-ribosylation is a fundamental posttranslational modification where ADP-ribose is linked on to target proteins by ADP-ribose transferases and removed by the ADP-ribose hydrolases. Read more

Supervisor: Dr L McGurk

Year round applications PhD Research Project Self-Funded PhD Students Only

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Advancing translational cell therapy for Hirschsprung disease

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

Clinical disorders characterised by neuronal loss or dysfunction in the gastrointestinal tract remain some of the most challenging to manage, with considerable morbidity and mortality and very limited treatments. Read more

Supervisors: Dr C McCann, Prof P De Coppi

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Developing an ADAR-mediated RNA editing therapy for treatment of Duchenne Muscular Dystrophy

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

Duchenne muscular dystrophy (DMD) is a severe X-linked genetic disorder affecting 1:5000 boys at birth (1). DMD is caused by mutations in Dystrophin gene, with around 10% of the cases caused by nonsense mutations (2,3). Read more

Supervisors: Dr HZ Zhou, Dr J Meng, Prof F Muntoni

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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How to build and maintain a 3-dimensional polarised epithelial sheet

University of Nottingham School of Life Sciences

We are interested in how cells maintain normal cell shape within an epithelium. Correct epithelial cell shape is essential to maintain tissue integrity and when deregulated can cause diseases such as malignant cancers, diabetes, inflammation, and aging. Read more

Supervisor: Dr M Georgiou

Year round applications PhD Research Project Self-Funded PhD Students Only

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Short and long-term genetic and behavioural consequences of traumatic brain injury in fruit flies

University of Leicester Department of Genetics and Genome Biology

General background . How many fingers am I holding up? What day of the week is it? Follow my finger? These three questions are designed to test your sensory, memory and motor neural abilities following an accident; all three systems are affected by a severe deceleration of your brain. Read more

Supervisors: Dr B Warren, Dr E Rosato, Dr R Feuda

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Optogenetic sculpting of next-generation organoids for disease modelling of congenital malformations including spina bifida

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

The ability to generate human induced pluripotent stem cells (iPSC) from adult cell types has revolutionised regenerative medicine research. Read more

Supervisors: Dr G Galea, Prof J Sowden

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Leveraging novel automated diagnostic pathways with augmented precision medicine approaches for the early detection and risk stratification of liver disease

University of Dundee School of Medicine

Liver disease represents one of the fastest-growing causes of morbidity and mortality in the world. The principle aetiological variants are contained within the new nomenclature of steatotic liver disease (SLD). Read more

Supervisors: Dr P Brennan, Prof J F Dillon, Dr M Al-Khairalla

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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Utility of in silico prediction tools to aid variant interpretation

University of Dundee School of Medicine

Accurate variant interpretation represents is essential for the successful implementation of genetic testing in the clinical setting. Read more

Supervisor: Dr P Newey

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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We have 76 Genetics (system) PhD Projects, Programmes & Scholarships

Genetics (system) PhD Projects, Programmes & Scholarships

We have 76 Genetics (system) PhD Projects, Programmes & Scholarships

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