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We have 17 Genetics (tumour) PhD Projects, Programmes & Scholarships

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Genetics (tumour) PhD Projects, Programmes & Scholarships

We have 17 Genetics (tumour) PhD Projects, Programmes & Scholarships

The role of calcium signalling in regulating of tumour cell behaviour

Metastasis is the major cause of mortality in human cancers, yet we know relatively little of the fundamental biology that underlies the important transition to invasive malignancy. Read more

Exploring the role of interferon stimulated genes (ISGs) in stem cells of serous ovarian cancer

  Research Group: Institute of Cancer Therapeutics
Epithelial ovarian cancer (EOC) is the leading cause of mortality in women due to gynaecological cancers. High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of patients with EOC. Read more

The analysis of HIF function in DNA repair and genome stability

DNA damage is a factor that underlies many human diseases. Such damage results in mutations, and if such genetic alterations occur in tumour suppressor or proto-oncogenes it can lead to cancer. Read more

Multilevel selection on transposition rates in cancer

Cancer is an evolutionary process. Cells in a tumour vary due to mutation, and so over many generations they adapt in response to both intrinsic selective pressures (such as anoxia) and extrinsic selective pressures (such as chemotherapy). Read more

Vascularising human mini-brains in a dish

Blood vessels play a pivotal role in brain development and function. They promote tissue growth and survival by supplying nutrients and oxygen to surrounding tissues, signals to progenitor populations, as well as guiding neuronal migration. Read more

Genomics of malignant pleural mesothelioma

Malignant pleural mesothelioma is a rare, incurable cancer that carries a dismal prognosis. Its incidence is increasing globally despite its primary cause, asbestos exposure, having been known for over 50 years. Read more

Probing Death Decisions from Morphogen Gradient Fields

Morphogen gradient scaling is one of the hottest fields in developmental biology at the moment. Scaling is fundamental, explaining how the machinery that controls pattern formation in development (the morphogens) can adapt, so that organs of different sizes show morphological structures which are proportioned. Read more

Eliminating Harmful Cells to Maintain Homeostatis and Prevent Tumorigenesis

Hamaratoglu Lab studies cell-cell signalling in development, homeostasis and tumourigenesis. We take advantage of outstanding genetic tools in Drosophila, and use larval imaginal discs as model epithelial organs. Read more

Role of BTG1 and BTG2 in acute lymphocytic leukaemia and diffuse large B-cell lymphoma

Acute lymphocytic leukaemia (ALL) and diffuse large B-cell lymphoma (DLBCL) is often associated with small deletions of or point mutations in the highly related BTG1 or BTG2 genes. Read more

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