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We have 17 Pharmacy (cell and molecular biology) PhD Projects, Programmes & Scholarships

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Pharmacy (cell and molecular biology) PhD Projects, Programmes & Scholarships

We have 17 Pharmacy (cell and molecular biology) PhD Projects, Programmes & Scholarships

Assessing the molecular mechanisms by which Cathepsin V promotes breast cancer growth and metastasis

Targeted therapies such as tamoxifen, fulvestrant and anastrozole have exhibited significant clinical success since being introduced as treatments for Estrogen Receptor positive (ER+) breast cancer patients. Read more

Development of novel lipid nanoparticles (LNPs) for targeted gene delivery to cancer cells

Applications are invited for a self-funded, 3 year full-time PhD project. The PhD will be based in the School of Pharmacy and Biomedical Science and will be supervised by Dr Roja Hadianamrei and Dr Sassan Hafizi. Read more

Exploring the molecular mechanisms of skin aging process and understanding the relationship between skin aging and systemic aging

Applicants are invited for fully funded 3 years full time PhD studentships, starting from 1st February 2023, or 1st April 2023, or 1st October 2023 at latest, based in the School of Pharmacy, The University of Nottingham. Read more

Does one size fit all for antimicrobial delivery via nanoparticles

Antimicrobial resistant bacteria are a growing problem and new ways are needed to target bacterial infections more efficiently. One way in which bacteria can avoid therapeutics is via intracellular infection, where they hide within our own cells. Read more

Designing and evaluating novel nanotherapeutics to enhance the effectiveness of radiotherapy in the treatment of solid cancers.

One in two cancer patients will receive radiotherapy as part of their treatment. For patients with a localised cancer diagnosis effective radiotherapy represents the best chance of a curative outcome, however, is not without risk. Read more

Peptide-based nanoparticles for brain targeted gene delivery.

Gene therapy has the potential to provide therapeutic benefit to millions of people with neurodegenerative diseases and cancer. Delivery into the brain is hampered by the blood-brain barrier (BBB), which limits the efficacy of both conventional and novel therapies at the target site. Read more

Regulation of CaaX protein processing

USP17 is over-expressed in a range of primary tumours including NSCLC, breast, colorectal, cervical, ovarian and osteosarcoma and its depletion has been shown to block the growth of cells from all these cancer types, as well as the migration of a range of cancer cells (NSCLC, breast, ovarian, osteosarcoma).    . Read more

Structure-based design of allosteric modulators for G protein-coupled receptors using molecular modelling and pharmacology experiments

Almost all physiological processes are regulated through the activation of G protein-coupled receptors (GPCRs). It has become widely accepted that most GPCRs possess binding sites spatially distinct from their natural ligand binding site (orthosteric site), termed as allosteric sites. Read more

Ion channel signalling in cancer cells

Our cells constantly sense and transport ions present in their environment. From embryonic development to epilepsy to heart disease to cancer, our cells’ ability to respond to changes in the ionic microenvironment is essential for healthy ageing. Read more

Novel strategy for treatment of chronic wounds via multi-functional liposomal nanocarriers

  Research Group: Medicines Development and Pharmaceutical Sciences
A confounding issue of non-healing skin wounds is the presence of pathogenic bacteria, that protect themselves from conventional antibiotic treatments by encasing themselves within protective shields (biofilms). Read more

Targeting the MAPK scaffold protein KSR1 for the treatment of prostate cancer

  Research Group: Institute of Cancer Therapeutics
Prostate cancer is one of the leading causes of male cancer deaths. It arises when individual cells escape their normal growth control mechanisms and proliferate in an uncontrolled fashion. Read more

How does the dynamic intra-membrane aggregation of phage lysis proteins kill bacterial pathogens?

This is an interdisciplinary project. It will provide a unique opportunity to obtain training in a wide range of interdisciplinary skills, including protein engineering techniques, protein purification, atomic force microscopy, neutron reflection and scattering as well as molecular dynamics simulations. Read more

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