Many proteins in human cells function as part of high molecular weight multi-subunit assemblies. The structure and function of such large molecular machines is often difficult to characterise due to their complexity, low abundance and structural dynamics. Read more

Supervisor: Dr G S Winkler

Year round applications PhD Research Project Self-Funded PhD Students Only

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Overcoming replication stress–defining new mechanism from archaea to human

University of Nottingham School of Life Sciences

How cells respond to DNA replication stresses (e.g., DNA replication collapse, stalling or hyper-activity) is critical for their survival, and is a hallmark of cancers. Read more

Supervisors: Dr E Bolt, Prof T Allers

Year round applications PhD Research Project Self-Funded PhD Students Only

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The role of microtubule regulators in the progression of cancer: investigating the link between BRCA2 and depolymerising kinesins.

University of Nottingham School of Life Sciences

The mitotic kinesin KIF2C/MCAK regulates microtubule length in the mitotic spindle and plays a role in preventing chromosome-microtubule attachment errors. Read more

Supervisors: Dr C Friel, Dr S Wheatley

Year round applications PhD Research Project Self-Funded PhD Students Only

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