University of Liverpool Physiology PhD Projects, Programmes & Scholarships

We have 15 University of Liverpool Physiology PhD Projects, Programmes & Scholarships

Investigating local invasion in primary and secondary brain tumours

University of Liverpool Department of Molecular and Clinical Cancer Medicine

Brain tumours are highly invasive and carry a poor prognosis. Secondary brain tumours or brain metastases (BM) are the most common tumours found in the brain affecting up to one third of patients with solid organ cancer. Read more

Supervisor: Dr RZ Zakaria

2 December 2024 PhD Research Project Self-Funded PhD Students Only

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Study of early pathological changes in calcified cartilage in osteoarthritis and alkaptonuria

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

We are seeking a motivated individual to work on this exciting project investigating the role that the calcified cartilage has in rare and common joint osteoarthritis, using novel approaches such as gene silencing and establishment of a 3D chondrocyte cell culture model. Read more

Supervisor: Dr JH Hughes

10 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Development of novel therapies for Hirschsprung’s Disease

University of Liverpool Faculty of Health and Life Science

As a PhD student, you'll be part of a groundbreaking project aiming to revolutionise the treatment landscape for Hirschsprung's Disease (HSCR). Read more

Supervisors: Miss RH Harwood, Dr B Wilm, Miss SA Almond

26 April 2024 PhD Research Project Funded PhD Project (European/UK Students Only)

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Gaining mechanistic insights into Atrial Fibrillation: Bench to bedside approaches

University of Liverpool Department of Pharmacology and Therapeutics

Atrial fibrillation (AF) is a common arrhythmia with symptoms like irregular heart rate, palpitations, shortness of breath, tiredness, and dizziness. Read more

Supervisor: Dr RB Burton

1 July 2024 PhD Research Project Self-Funded PhD Students Only

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Preclinical testing of collagen synthesis inhibitors for fibrotic disease

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Fibrotic disease is characterised by an excessive accumulation of collagen within tissues, which then impedes tissue function. Organ fibrosis specifically kidney fibrosis, liver fibrosis, cardiac fibrosis and lung fibrosis have limited treatment options, pose a huge clinical burden and are life-limiting diseases. Read more

Supervisor: Dr EG Laird

Year round applications PhD Research Project Self-Funded PhD Students Only

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Alterations in reparative dentinogenesis with ageing, gender and genetic predisposition

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Dental pulp exposure caused by tooth decay or injury can lead to life-threatening infections. Following injury, reparative dentinogenesis serves a vital purpose through the accelerated generation of tertiary dentine, comprising mineral and type I collagen. Read more

Supervisors: Dr EG Laird, Dr N Longridge, Prof FJ Jarad

Year round applications PhD Research Project Self-Funded PhD Students Only

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Using pre-clinical models of disease to define new targets to slow joint degeneration in osteoarthritis

University of Liverpool Institute of Life Course and Medical Sciences

The main overall aim of this project is to understand mechanisms of joint degeneration during osteoarthritis progression in order to define new targets for therapy. Read more

Supervisor: Dr B Poulet

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the role of Aquaporins in age related diseases

University of Liverpool Institute of Life Course and Medical Sciences

Physical frailty, with its associated immobility and disability, is a major factor limiting independence among older people. A key contributor to frailty is a decline in muscle mass and strength (sarcopenia) and the burden of sarcopenia is substantial, with a cost to the NHS of ~£2.5bn/pa. Read more

Supervisor: Dr C Staunton

Year round applications PhD Research Project Self-Funded PhD Students Only

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Control of bone shape and function by the extracellular matrix Fibrillin-1

University of Liverpool Institute of Life Course and Medical Sciences

Bones are tightly regulated structures that remodel their structure to adapt to changes in their mechanical environment. With ageing, this mechanical response is often dampened, leading to bone loss and weakness. Read more

Supervisor: Dr B Poulet

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the role of oxidative metabolites in joint destruction in osteoarthritis

University of Liverpool Institute of Life Course and Medical Sciences

We are seeking a motivated researcher to work on a pioneering project investigating the role of oxidative stress in alkaptonuria (AKU) and associated conditions. Read more

Supervisors: Dr BN Norman, Dr JH Hughes, Prof G Bou-Gharios

Year round applications PhD Research Project Self-Funded PhD Students Only

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Exploring tyrosine metabolism as a source of oxidative stress

University of Liverpool Institute of Life Course and Medical Sciences

We are seeking a motivated researcher to work on a pioneering project investigating the role of oxidative stress associated with tyrosine metabolism. Read more

Supervisors: Dr BN Norman, Dr JH Hughes, Prof L Ranganath

Year round applications PhD Research Project Funded PhD Project (UK Students Only)

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Cardiac Harmony: Modelling Heart Beats with Stem Cells and Code

University of Liverpool Institute of Life Course and Medical Sciences

Despite significant advancements in cardiac research, heart disease remains a leading cause of mortality globally. Unexpected cardiac events can occur even in young, fit individuals engaged in routine activities. Read more

Supervisors: Prof R Barrett-Jolley, Dr R Oldershaw

Year round applications PhD Research Project Self-Funded PhD Students Only

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The effect of low protein diet on the development of the neuromuscular system

University of Liverpool Institute of Life Course and Medical Sciences

Age-related sarcopenia is characterised by reduction in the number of myofibres and motor neurons and an additional weakening of the remaining fibres, causing reduction in muscle mass and function. Read more

Supervisor: Dr A Vasilaki

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the cellular functions of Trappc9 in brain development and microcephaly

University of Liverpool Institute of Systems, Molecular and Integrative Biology

This PhD project will investigate the cellular functions of the Trafficking protein particle complex subunit 9 (Trappc9) and its roles in brain development. Read more

Supervisors: Dr A Plagge, Dr T Zech

Year round applications PhD Research Project Self-Funded PhD Students Only

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Analysis of the role of liver sinusoidal endothelial cells in methotrexate-induced liver toxicity

University of Liverpool Department of Pharmacology and Therapeutics

Liver sinusoidal endothelial cells (LSECs) comprise approximately 50% of the non-parenchymal hepatic cells. They play a vital role in hepatic microcirculation and provide a physiological barrier to the movement of xenobiotics from the bloodstream to hepatic tissue. Read more

Supervisors: Dr M Cross, Prof C Goldring

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 15 University of Liverpool Physiology PhD Projects, Programmes & Scholarships

University of Liverpool Physiology PhD Projects, Programmes & Scholarships

We have 15 University of Liverpool Physiology PhD Projects, Programmes & Scholarships

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