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We have 14 Physiology (heart disease) PhD Projects, Programmes & Scholarships

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Physiology (heart disease) PhD Projects, Programmes & Scholarships

We have 14 Physiology (heart disease) PhD Projects, Programmes & Scholarships

Biomechanical signalling in human heart disease

About the Project. The human heart undergoes more than 2 billion beats throughout an individual's lifetime, with its rhythm precisely regulated by signalling events that continuously adapt to the biomechanical stress exerted on the ventricular walls. Read more

Cardiac Harmony: Modelling Heart Beats with Stem Cells and Code

Despite significant advancements in cardiac research, heart disease remains a leading cause of mortality globally. Unexpected cardiac events can occur even in young, fit individuals engaged in routine activities. Read more

Ion channel signalling in cancer cells

Our cells constantly sense and transport ions present in their environment. From embryonic development to epilepsy to heart disease to cancer, our cells’ ability to respond to changes in the ionic microenvironment is essential for healthy ageing. Read more

Role of RyR2 posttranslational modification in arrhythmias

Cardiac arrhythmias remain the leading cause of death in patients with heart disease. An important trigger for arrhythmias is the inappropriate opening of the cardiac ryanodine receptor (RyR2). Read more

Molecular mechanisms of pacemaker (sinus node) dysfunction in ageing, heart failure and athletes

  Research Group: Chemistry and Biosciences
The heart’s pacemaker, the sinus node, initiates the action potential that causes the heart to beat, and the atrioventricular node conducts the action potential from the atria to the ventricles, the pumping chambers of the heart. Read more

Machine learning to predict blood function – towards better haematology analysis

Blood represents a complex mixture of blood cells, plasma proteins, hormones, lipids, salts and water. Blood is good indicator of health, and clinically, blood samples are taken frequently to monitor health, risk of disease or success of treatments. Read more

Using microRNA inhibitors to boost GABAergic inhibition as a genetic therapy for epilepsy

Epilepsy is a chronic neurological disease characterised by recurrent spontaneous seizures and cognitive co-morbidities. Current small molecule approaches to treating epilepsy are ineffective in a significant portion of cases, and are associated with substantial adverse effects. Read more

Mechanisms underlying the effects of activated protein C (APC) in cardiac muscle

  Research Group: Chemistry and Biosciences
APC is an anticoagulant enzyme that also exerts antithrombotic, anti-inflammatory, antiapoptotic and a variety of other cytoprotective effects in different tissues, where the mechanism of action is thought to involve the endothelial protein C receptor (EPCR) and a protease activated receptor (PAR). Read more

Molecular mechanisms of the increase in maximal aerobic capacity (VO2max) with regular exercise

  Research Group: PENRG - Physiology Exercise and Nutrition Research Group
Performing regular exercise is crucial for good health and wellbeing, whereas failing to perform sufficient exercise increases the risk of diseases such as cardiovascular disease, type 2 diabetes, cancer, etc. Read more
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