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We have 13 Pharmacology (quantitative) PhD Projects, Programmes & Scholarships

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Pharmacology (quantitative) PhD Projects, Programmes & Scholarships

We have 13 Pharmacology (quantitative) PhD Projects, Programmes & Scholarships

Quantitative prediction of drug metabolism mechanism

Faculty of Pharmacy, Charles University, Department of Pharmacology and Toxicology . The project aim is the high-accuracy prediction of drug metabolism mechanism with the help of atomistic simulations at quantum accuracy and machine learning. Read more

Discovering off-target side-effects and drug repurposing candidates using expression perturbation data

The MRC Integrative Epidemiology Unit at the University of Bristol is the leading group for the development and application of causal analysis and evidence triangulation in health research to improve lives. Read more

(MRC DTP CASE) Understanding how tumour associated macrophages control the tumour immune landscape in NF2-Schwannomatosis

Type 2 Neurofibromatosis (NF2), now referred to as NF2-Schwannomatosis (or NF2-SWN), is a rare autosomal dominant tumour pre-disposition syndrome characterised by growth of typically benign tumours throughout the nervous system. Read more

Discovery and profiling of small-molecule inhibitors of cellular nuclease enzymes

Nuclease enzymes are non-traditional drug targets that attract an increasing amount of interest as potential targets relevant for a variety of therapeutic areas including infection, cancer and bone disease. Read more

Personalising cancer treatment with tumour evolution modelling using AI-based genomics biomarkers and PK/PD

Tumour heterogeneity is a major problem limiting the efficacy of targeted oncological therapies. Most advanced tumours eventually become resistant to the treatments, ultimately making the patient succumb to metastatic disease. Read more

Network-based predictive modelling of cardiovascular disease risk

The risk of cardiovascular disease (CVD) is orchestrated by multiple factors. QRISK models (currently QRISK3) have been used in the UK to estimate CVD risk within the next 10 years for individuals without CVD. Read more

Investigating the roles that G protein coupled receptors play in hypertension

G protein-coupled receptors (GPCRs) constitute a very large family of heptahelical, integral membrane proteins that mediate a wide variety of physiological processes ranging from the transmission of light and odorant signals to the mediation of neurotransmission and hormonal actions. Read more

Investigating the Roles for deSUMOylation Enzyme SENP3 in Autophagy Impaired by α-synuclein

Aggregation of α-synuclein protein in neuronal cells has been strongly implicated in the pathogenesis of neurodegenerative disorders (Synucleinopathies) including Parkinson's disease and dementia with Lewy bodies. Read more

Mechanisms of Cancer Stem Cell Survival, Metastasis Formation and Immune Evasion in Cancer

Recent research suggests that cancer cells within a tumour represent a highly heterogeneous cell population. In particular many tumours contain small percentage of cells that share several characteristics with stem cells. Read more
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