Pathology (genetic) PhD Projects, Programmes & Scholarships

We have 30 Pathology (genetic) PhD Projects, Programmes & Scholarships

Identifying causal pathways to disease using DNA methylation predicted blood traits.

University of Bristol Bristol Medical School

Project Background. Blood cell types have been implicated in pathogenesis of chronic diseases. Genome wide association studies have identified thousands of variants associated with blood trait variation. Read more

Supervisors: Dr J Min, Dr E Hannon, Prof J MIll

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Harnessing the genetics of DNA methylation to understand context-specific gene regulation in disease

University of Bristol Bristol Medical School

Project Background. Genome wide association studies (GWAS) have discovered many genetic associations with health outcomes. However, most GWAS signals reside in non-coding regions and it is likely that GWAS variants confer their effects through a regulatory mechanism. Read more

Supervisors: Dr J Min, Dr E Hannon, Prof J MIll, Dr GL Leyden

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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An investigation of the causal relationship and genetic overlap between sleep traits and physical and mental health using Mendelian randomization

University of Bristol Bristol Medical School

Rationale. Sleep has long been known to play a role in physical and mental wellbeing and sleep disruption has been observed to co-occur with a number of health conditions including. Read more

Supervisors: Dr S Lewis, Dr MR Renteria, Dr HJ Jones

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Skeletal Muscle Organoid Models for Genetic Mitochondrial Disease (ref: SF22/HLS/APP/Johnson)

Northumbria University Faculty of Health and Life Sciences

Genetic mitochondrial diseases are both clinically and genetically heterogeneous. Read more

Supervisor: Dr S Johnson

Year round applications PhD Research Project Self-Funded PhD Students Only

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Genetics: Investigating the functional effect of novel genes and genetic variants in malignant hyperthermia susceptibility using model systems

University of Leeds Faculty of Medicine and Health

Malignant hyperthermia (MH) is an inherited condition, where patients exposed to anaesthetic drugs are susceptible to a dramatic hyperthermic and hypermetabolic response that can contribute to a significant proportion of post-operative morbidity and deaths. Read more

Supervisors: Prof P Hopkins, Dr M-A Shaw, Dr C Diggle

Year round applications PhD Research Project Self-Funded PhD Students Only

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Leveraging Functional Genomics to Understand Mitonuclear Combinations in Leber Hereditary Optic Neuropathy (Ref: FFS24/HLS/APP/WINTER)

Northumbria University Faculty of Health and Life Sciences

Mitochondria are small structures present in every cell of our body, which convert the food we eat into an energy source that cells can use. Read more

Supervisors: Dr M Winter, Prof M Lako, Dr G Hilgen

25 April 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Investigating the genetic determinants of ultra-complex telomere fusion

Cardiff University Cardiff School of Medicine

We are seeking a motivated molecular biologist to study the mechanisms by which telomere dysfunction impacts cancer genomes. Read more

Supervisor: Prof D Baird

3 May 2024 PhD Research Project Funded PhD Project (European/UK Students Only)

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Alterations in reparative dentinogenesis with ageing, gender and genetic predisposition

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Dental pulp exposure caused by tooth decay or injury can lead to life-threatening infections. Following injury, reparative dentinogenesis serves a vital purpose through the accelerated generation of tertiary dentine, comprising mineral and type I collagen. Read more

Supervisors: Dr EG Laird, Dr N Longridge, Prof FJ Jarad

Year round applications PhD Research Project Self-Funded PhD Students Only

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Linking multivariable Mendelian randomization with lifecourse epidemiology: developing the methodology and application to a contemporary exemplar

University of Bristol Bristol Medical School

Rationale. Mendelian randomization (MR) uses genetic variants as instrumental variables to estimate the causal effect of an exposure on an outcome, free from bias due to unobserved confounding. Read more

Supervisors: Dr E Sanderson, Prof K Tilling, Prof G Davey-Smith

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Identifying causal risk factors and outcomes of atopic dermatitis

University of Bristol Bristol Medical School

Rationale. Several traits such as cardiovascular disease[1] and mental health disorders[2] have been reported to be observationally associated with atopic dermatitis (AD). Read more

Supervisors: Dr A Budu-Aggrey, Dr L Paternoster

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Identifying causal risk factors for disease progression

University of Bristol Bristol Medical School

Rationale. Typical epidemiological studies aim to identify causal risk factors for onset of disease by comparing diseased cases with disease free controls. Read more

Supervisors: Dr L Paternoster, Prof G Davey-Smith, Dr A Hartley

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Experimental and computational Cancer PhD: Overcoming osteosarcoma chemoresistance by characterizing and targeting cellular quiescence

University College London UCL Cancer Institute

Cancer is the leading cause of death in children and the second in young adults in England and Wales. Sarcomas, tumours that originate from connective tissues (bone, muscle, fat), account for around 15% of childhood cancers. Read more

Supervisors: Dr M Secrier, Dr L Cottone

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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The role of extracellular vesicles and intercellular signalling in inherited kidney cancer

Cardiff University Cardiff School of Medicine

This is a Self-Funded/Sponsored PhD opportunity. FUNDING REQUIRED. Full UK/EU or International Tuition Fees. UK Living Expenses. Bench Fees (£60,000 total). Read more

Supervisor: Dr E Dunlop

31 May 2024 PhD Research Project Self-Funded PhD Students Only

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Estimating the global cancer burden due to low levels of physical activity

University of Bristol Bristol Medical School

Rationale. Around 40% of all cancers are thought to be avoidable by modification of lifestyle factors. Obesity has been found to be a risk factor for several cancers and was estimated to have caused around 3.6% of all new cancers which occurred in 2012. Read more

Supervisors: Dr S Lewis, Prof R Martin, Dr R Pulsford, Prof R Jago, Dr FB Bray

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Mendelian Randomisation for mediation analysis with multiple mediators: theory and applications

University of Bristol Bristol Medical School

Rationale. Many of an individual’s traits are observationally associated with their health outcomes. Understanding the relationships between these factors is critical to effective public health intervention. Read more

Supervisors: Dr E Sanderson, Dr R Daniel, Dr L Howe

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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We have 30 Pathology (genetic) PhD Projects, Programmes & Scholarships

Pathology (genetic) PhD Projects, Programmes & Scholarships

We have 30 Pathology (genetic) PhD Projects, Programmes & Scholarships

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