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We have 31 Cell Biology PhD Projects, Programmes & Scholarships in Bristol

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Cell Biology PhD Projects, Programmes & Scholarships in Bristol

We have 31 Cell Biology PhD Projects, Programmes & Scholarships in Bristol

University of Bristol

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Harnessing the genetics of DNA methylation to understand context-specific gene regulation in disease

University of Bristol Bristol Medical School
Genome wide association studies (GWAS) have discovered many genetic associations for traits and diseases. However, most GWAS signals reside in non-coding regions (outside genes), and it is likely that GWAS variants confer their effects through modulating regulatory mechanism. Read more
 Supervisor: Dr J Min
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Endothelial glycocalyx damage as a therapeutic target in sepsis-associated Acute Kidney Injury

University of Bristol Bristol Medical School
Sepsis is the leading cause of acute kidney injury (sAKI), associated with high morbidity and mortality.1,2 Unfortunately, there is no treatment for sAKI, current therapies are nonspecific and supportive of the vital organ systems in the hope the kidney will recover. Read more
 Supervisor: Prof S Satchell
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Creating patient-specific retinal organoids from human induced pluripotent stem cells for in vitro simulation of uveitis

University of Bristol Bristol Medical School
Uveitis, although uncommon, is a notable cause of visual impairment and blindness. Uveitis encompasses a range of conditions driven by both innate autoinflammatory and adaptive autoimmune CD4 T-cell responses. Read more
 Supervisor: Dr P Maghsoudlou
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Identifying causal risk factors and outcomes of atopic dermatitis

University of Bristol Bristol Medical School
Rationale. Several traits such as cardiovascular disease[1] and mental health disorders[2] have been reported to be observationally associated with atopic dermatitis (AD). Read more
 Supervisors: Dr A Budu-Aggrey, Dr L Paternoster
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Investigating the genetic architecture of orofacial cleft: A genome-wide association study using trio data and an investigation of parent of origin and mother-children interaction effects.

University of Bristol Bristol Medical School
Rationale. Orofacial clefts (OFCs) are the most prevalent craniofacial congenital disabilities globally, occurring at a frequency of 1 out of 700 newborns. Read more
 Supervisors: Dr S Lewis, Dr E Stergiakouli, Prof H Cordell
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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An investigation of the causal relationship and genetic overlap between sleep traits and physical and mental health using Mendelian randomization

University of Bristol Bristol Medical School
Rationale. Sleep has long been known to play a role in physical and mental wellbeing and sleep disruption has been observed to co-occur with a number of health conditions including. Read more
 Supervisors: Dr S Lewis, Dr MR Renteria, Dr HJ Jones
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Identifying causal risk factors for disease progression

University of Bristol Bristol Medical School
Rationale. Typical epidemiological studies aim to identify causal risk factors for onset of disease by comparing diseased cases with disease free controls. Read more
 Supervisors: Dr L Paternoster, Prof G Davey-Smith, Dr A Hartley
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Causal risk factors and biological mechanisms for colorectal cancer risk

University of Bristol Bristol Medical School
Rationale. Diet and lifestyle are likely to play an important role in colorectal cancer risk; obesity, low levels of physical activity, red and process meat consumption and low intake of dietary fibre have all been shown to predict colorectal cancer risk. Read more
 Supervisors: Dr S Lewis, Dr KT Tsilidis
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Identifying metabolic drivers of cancer development

University of Bristol Bristol Medical School
Rationale. Growing evidence suggests that cell extrinsic factors are key in modulating tumor progression. Metabolites are small molecules that act as sources of fuel and building blocks essential for cells and tissues when present at normal levels. Read more
 Supervisors: Dr E Vincent, Dr CB Bull, Prof N Timpson
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Mendelian Randomisation for mediation analysis with multiple mediators: theory and applications

University of Bristol Bristol Medical School
Rationale. Many of an individual’s traits are observationally associated with their health outcomes. Understanding the relationships between these factors is critical to effective public health intervention. Read more
 Supervisors: Dr E Sanderson, Dr R Daniel, Dr L Howe
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Evaluating the role of circulating proteins in cancer risk and progression using genetic and observational approaches

University of Bristol Bristol Medical School
Rationale. Circulating proteins play fundamental roles in biology and disease aetiology, including development of cancer, and are the direct targets of many drugs (1). Read more
 Supervisors: Prof R Martin, Dr JY Yarmolinsky, Dr P Haycock
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Harnessing genetics of DNA methylation to elucidate molecular mechanisms underlying human phenotypes.

University of Bristol Bristol Medical School
Rationale. GWAS studies have discovered many genetic associations for traits and diseases, but it has been difficult to elucidate the functional consequences of these variants. Read more
 Supervisors: Dr J Min, Prof C Relton, Prof J MIll, Dr E Hannon, Dr G Hemani, Prof T Gaunt, Dr B Heijmans, Dr J Bell
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Establishing and orienting causal relationships between sleep characteristics and reproductive function

University of Bristol Bristol Medical School
Rationale. A large body of literature from animal studies has highlighted the role of core clock genes in relation to reproductive function [1]. Read more
 Supervisors: Dr R Richmond, Dr G Sharp, Prof D Lawlor
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Breastfeeding and big babies - lifecourse and genomics epidemiological approaches to disentangle cause and effect.

University of Bristol Bristol Medical School
Rationale. The World Health Organisation recommends exclusively breastfeeding for 6 months, but in the UK, only 1% of infants meet the guidelines (1). Read more
 Supervisors: Dr L Zuccolo, Dr LJ Johnson, Dr L Howe, Dr C Borges
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Identifying causal pathways to disease using DNA methylation predicted blood traits.

University of Bristol Bristol Medical School
Project Background. Blood cell types have been implicated in pathogenesis of chronic diseases. Genome wide association studies have identified thousands of variants associated with blood trait variation. Read more
 Supervisors: Dr J Min, Dr E Hannon, Prof J MIll
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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