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We have 51 Cell Biology PhD Projects, Programmes & Scholarships in Leeds

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Biological Sciences

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Leeds  United Kingdom

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Cell Biology PhD Projects, Programmes & Scholarships in Leeds

We have 51 Cell Biology PhD Projects, Programmes & Scholarships in Leeds

Investigation of antagonism of multiple RGD-binding integrins as a therapeutic strategy in advanced head and neck cancer

  Research Group: Institute of Cancer Therapeutics
Background. The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis. Read more

Cancer: Inhibiting cell metabolism to enhance tumour cell death

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow. Read more

Cancer: Repurposing drugs as new treatments for breast cancer

Breast cancer (BC) is the most common cancer, with over 1 million new cases diagnosed worldwide each year. For some types of BC, hormonal treatments have been very effective but one particular BC subtype, triple negative breast cancer (TNBC), is highly aggressive and lacks a targeted therapy. Read more

Cancer: Understanding the immunosuppressive role of fibroblast and macrophages in Breast cancer

Oncolytic viruses (OVs) preferentially infect and kill cancer cells, and their clinical efficacy has been demonstrated against a number of different cancers. The most clinically advanced OV is a genetically engineered herpes simplex virus (T-VEC) which expresses GMCSF to aid the development of anti-tumour immune responses; T-VEC is approved for the treatment of metastatic melanoma. Read more

Control and inhibition of virus replication

The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specifically Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets. Read more

The role of ubiquitin-modifying enzymes in angiogenesis

The School of Molecular & Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

The role of vitamin D3 in treating skin cancer and preventing drug resistance

  Research Group: Chemistry and Biosciences
During the last decade numerous studies have alluded to vitamin D. 3. playing a role in the prevention of cancer. Recent clinical trials looking at the potential role of vitamin D. Read more

NIHR Leeds BRC: Force sensing mechanisms of haemostasis in heart failure and diabetes

Since the original identification of the role of PIEZO1 in vascular integrity and endothelial cell biology by our group in Leeds in 2014, there have been many publications on the role of PIEZO1 in endothelial function and its role in processes such as atherosclerosis, hypertension, cell-cell junctions, vascular permeability and leukocyte diapedesis. Read more

How does myosin 10 contribute to filopodia formation and stability?

How do cells make filopodia? Filopodia are thin protrusions that act as pathfinders in cell migration, helping cells to sense where to go, and pulling cells through the extracellular matrix, especially important in driving cancer cell metastasis. Read more

Development of chemical tools and bioactive compounds to explore the importance of enzyme activity in cancer diseases

Diversity-oriented synthesis (DOS) is a modern chemical methodology, which aims to synthesise small molecules that cover new chemical space with the possibility of finding unexplored biological targets or pathways that may be important for disease progression. Read more

How to regulate plasticity in the brain

The Kwok Lab at the School of Biomedical Science invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

Immunotherapy: Killing Cancer using Dead Virus

It is now accepted that our immune systems can hold the key to treating otherwise incurable cancers. So-called “immunotherapy” is an increasingly common method of treating tumours, leading to impressive increases in patient responses. . Read more

Investigation of host-virus interactions

The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25 in the area of molecular virology. Read more

How do environmental cues affect reproduction?

This project is available to self funded candidates only. The School of Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

Manipulation of neuroimmune responses and behaviour by infectious agents

This project is available exclusively to self-funded students who wish to commence study for a PhD in the academic year 2023/24. The project focuses on how infectious agents modify the individuals that they infect and how neuroimmune responses to infection moderate behaviour changes in warm-blooded animals and humans. Read more

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