Cell Biology PhD Projects, Programmes & Scholarships in Liverpool

We have 34 Cell Biology PhD Projects, Programmes & Scholarships in Liverpool

Creation of cell lines modelling complex karyotype in B cell lymphomas using CRISPR/Cas9

University of Liverpool Institute of Systems, Molecular and Integrative Biology

Chronic lymphocytic leukaemia (CLL) and diffuse large B cell lymphoma (DLBCL) make up more than half of all the newly diagnosed cases of non-Hodgkin’s lymphoma (NHL), the 6th most common cancer in the UK. Read more

Supervisors: Dr J Slupsky, Dr N Kalakonda, Dr M Glenn

1 May 2024 PhD Research Project Self-Funded PhD Students Only

More Details

Determining metabolic reprogramming events in stem cells in response to inflammatory disease phenotype

University of Liverpool Institute of Life Course and Medical Sciences

Mesenchymal stem cells (MSCs) are responsible for the repair of damaged tissue following injury and disease as well as moderating innate and adaptive immune responses and regulation of self-tolerance and tissue homeostasis. Read more

Supervisors: Dr R Oldershaw, Dr A Chadwick, Dr M Phelan, Dr BN Norman

Year round applications PhD Research Project Self-Funded PhD Students Only

More Details

Biological pathways supporting the formation and function of chromatin (Scholarship)

University of Liverpool Institute of Systems, Molecular and Integrative Biology

Every cell in our body contains the same DNA yet each cell expresses a different set of genes. These changes in gene expression are heavily influenced by histone proteins, their role in packaging DNA into chromatin and the “epigenetic” information they carry. Read more

Supervisor: Dr CM Hammond

Year round applications PhD Research Project Self-Funded PhD Students Only

More Details

Probing Death Decisions from Morphogen Gradient Fields

University of Liverpool Department of Molecular and Clinical Cancer Medicine

Morphogen gradient scaling is one of the hottest fields in developmental biology at the moment. Scaling is fundamental, explaining how the machinery that controls pattern formation in development (the morphogens) can adapt, so that organs of different sizes show morphological structures which are proportioned. Read more

Supervisor: Dr MM Merino

Year round applications PhD Research Project Self-Funded PhD Students Only

More Details

Protecting cells from mechanical stress: A novel role of cell-surface receptor LRP1 in extracellular matrix- nuclei communication.

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Cellular adaptation to mechanical strain (mechano-adaptation) is increasingly understood to be conferred by Lamin intermediate filament proteins located within the nuclear lamina. Read more

Supervisor: Dr K Yamamoto

Year round applications PhD Research Project Self-Funded PhD Students Only

More Details

Using single cell transcriptomic and blood proteomic data to understand how pancreatic cancer causes diabetes and to find ways to detect the cancer earlier

University of Liverpool Department of Molecular and Clinical Cancer Medicine

Pancreatic cancer is the deadliest of the common cancers. Five-year survival remains low at 12%. Sadly for 80% of patients, by the time their cancer is diagnosed it has spread to distant organs making them ineligible for potentially curative surgery. Read more

Supervisor: Prof E Costello

23 May 2024 PhD Research Project Self-Funded PhD Students Only

More Details

Investigating the cellular functions of Trappc9 in brain development and microcephaly

University of Liverpool Institute of Systems, Molecular and Integrative Biology

This PhD project will investigate the cellular functions of the Trafficking protein particle complex subunit 9 (Trappc9) and its roles in brain development. Read more

Supervisors: Dr A Plagge, Dr T Zech

Year round applications PhD Research Project Self-Funded PhD Students Only

More Details

Investigating the impact of galectin-ligand interaction on cancer cell resistance to chemotherapeutic treatment

University of Liverpool Institute of Life Course and Medical Sciences

Galectins are multifunctional carbohydrate-binding proteins that are expressed by many types of human cells. Changes of galectin expression commonly occur in cancer (e.g. Read more

Supervisor: Prof LG Yu

Year round applications PhD Research Project Self-Funded PhD Students Only

More Details

Chromatin regulation of oncogenic transcription and replication stress: mechanism and functional implications in acute myeloid leukemia

University of Liverpool Institute of Systems, Molecular and Integrative Biology

This project focuses on the molecular mechanisms promoting acute myeloid leukaemia (AML), a disease of great unmet need. AML is an aggressive blood and bone marrow cancer characterized by abnormal proliferation and differentiation of myeloid cells. Read more

Supervisors: Dr M Papamichos Chronakis, Prof D MacEwan, Dr A Kanhere

Year round applications PhD Research Project Self-Funded PhD Students Only

More Details

Translating protection of cell-surface receptor LRP1 into potential disease-modifying therapies for osteoarthritis.

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Osteoarthritis (OA) causes pain and disability and is the most prevalent age-related joint disorder worldwide but there are no disease-modifying drugs available. Read more

Supervisors: Dr K Yamamoto, Prof G Bou-Gharios

Year round applications PhD Research Project Self-Funded PhD Students Only

More Details

Elucidation of a new pathological mechanism for brittle bone disease

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

The incidence of the brittle bone disease osteogenesis imperfecta (OI) is estimated to be around 1 in 10,000 individuals. The phenotypic spectrum of OI ranges from mild to perinatal lethal and includes extra-skeletal connective tissue manifestations. Read more

Supervisor: Dr EG Laird

Year round applications PhD Research Project Self-Funded PhD Students Only

More Details

Exploring the roles of dynamic atypical protein phosphorylation in cancer

University of Liverpool Institute of Systems, Molecular and Integrative Biology

Proteins are extensively regulated by dynamic, often reversible post-translational modifications (PTMs). This process allows cells to respond rapidly to environmental factors, be that e.g. Read more

Supervisors: Prof C E Eyers, Prof A Jones

Year round applications PhD Research Project Self-Funded PhD Students Only

More Details

Uncovering the mechanochemical signalling inputs that drive gastruloid axial patterning

University of Liverpool Institute of Life Course and Medical Sciences

How the early mammalian embryo converts a mass of identical cells in an organism with multiple axes of symmetry (anteroposterior, dorsoventral, mediolateral) is a critical question in developmental biology. Read more

Supervisor: Dr D Turner

Year round applications PhD Research Project Self-Funded PhD Students Only

More Details

Gaining mechanistic insights into Atrial Fibrillation: Bench to bedside approaches

University of Liverpool Department of Pharmacology and Therapeutics

Atrial fibrillation (AF) is a common arrhythmia with symptoms like irregular heart rate, palpitations, shortness of breath, tiredness, and dizziness. Read more

Supervisor: Dr RB Burton

1 July 2024 PhD Research Project Self-Funded PhD Students Only

More Details