We have 31 University of Bristol Cell Biology PhD Research Projects PhD Projects, Programmes & Scholarships

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University of Bristol Cell Biology PhD Research Projects PhD Projects, Programmes & Scholarships

We have 31 University of Bristol Cell Biology PhD Research Projects PhD Projects, Programmes & Scholarships

Self-funded PhD- Re-engineering Golgi dynamics in plants – investigating the role of myosin receptors

University of Bristol School of Biological Sciences

The growing global population requires the development of novel strategies to sustainably increase food production. Organelle movement is dynamic and linked to changes in cell size, plant biomass and in response to factors which affect food production such as pathogens (Perico and Sparkes, New Phytol. Read more

Supervisor: Dr I Sparkes

Year round applications PhD Research Project Self-Funded PhD Students Only

Self-funded MSc R- Re-engineering Golgi dynamics in plants – investigating the role of myosin receptors

University of Bristol School of Biological Sciences

The growing global population requires the development of novel strategies to sustainably increase food production. Organelle movement is dynamic and linked to changes in cell size, plant biomass and in response to factors which affect food production such as pathogens (Perico and Sparkes, New Phytol. Read more

Supervisor: Dr I Sparkes

Year round applications PhD Research Project Self-Funded PhD Students Only

Self-funded PhD- Exploring the Mechanisms of Bacterial Pathogen Entry and Colonization in Plants through Wounds

University of Bristol School of Biological Sciences

How bacterial pathogens enter and colonise plant via wounds?. Wounding of plants by hard wind, hail, heavy rain, sand storms, and frost is common in nature. Read more

Supervisors: Dr P Buscaill, Dr A Bailey

Year round applications PhD Research Project Self-Funded PhD Students Only

Self-funded MSc R- Understanding tumour-mediated suppression of cytotoxic T cell function by rebuilding suppression in vitro

University of Bristol School of Cellular and Molecular Medicine

Summary. Cytotoxic T cells have the capability of killing tumour target cells. However, this ability is commonly suppressed within the tumour microenvironment. Read more

Supervisor: Prof C Wuelfing

Year round applications PhD Research Project Self-Funded PhD Students Only

Self-funded PhD- Interplay between environmental toxins and cancer predisposition

University of Bristol School of Cellular and Molecular Medicine

Cancer arises in part from intrinsic molecular and cellular alterations. For instance, loss of major DNA damage response genes such as BRCA1/2 has long been known to predispose individuals to multiple cancer types. Read more

Supervisor: Dr S Koh

Year round applications PhD Research Project Self-Funded PhD Students Only

Self-funded PhD- Understanding tumour-mediated suppression of cytotoxic T cell function by rebuilding it in vitro

University of Bristol School of Cellular and Molecular Medicine

Summary. Cytotoxic T cells have the capability of killing tumour target cells. However, this ability is commonly suppressed within the tumour microenvironment. Read more

Supervisor: Prof C Wuelfing

Year round applications PhD Research Project Self-Funded PhD Students Only

Self-funded PhD- Integrated multi-omics characterisation of human retroviral reservoirs

University of Bristol School of Cellular and Molecular Medicine

Human retroviruses are a group of pathogens infecting an estimated 50 million people worldwide. The most widespread human retrovirus is HIV-1, which remains a major cause of morbidity and mortality, particularly in developing countries. Read more

Supervisor: Dr IL Shytaj

Year round applications PhD Research Project Self-Funded PhD Students Only

Self-funded PhD- Understanding Cell Biology through Imaging

University of Bristol School of Biochemistry

We study the trafficking and interaction of molecules and structures inside cells. Extracellular signals need to be processed in a correct manner for a cell to function properly. Read more

Supervisor: Prof P Verkade

Year round applications PhD Research Project Self-Funded PhD Students Only

Self-funded MSc R: Understanding Cell Biology Through Imaging

University of Bristol School of Biochemistry

We study the trafficking and interaction of molecules and structures inside cells. Extracellular signals need to be processed in a correct manner for a cell to function properly. Read more

Supervisor: Prof P Verkade

Year round applications PhD Research Project Self-Funded PhD Students Only

Funded PhD - The mechanisms of cognition in bees and flies

University of Bristol School of Physiology, Pharmacology & Neuroscience

This project will be part of the Bristol-Macquarie Cotutelle Programme, funded by EPSRC. Read more

Supervisor: Prof J Hodge

1 August 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

Funded PhD - Determining the genetic and circadian basis of bipolar disorder

University of Bristol School of Physiology, Pharmacology & Neuroscience

This project will be part of the University of Bristol - University of Kent Cotutelle Programme. It will be jointly supervised by Prof James Hodge (http://www.bristol.ac.uk/phys-pharm-neuro/people-new/hodge/) and Dr Alice French at the University of Bristol, and by Prof Gurprit Lall at University of Kent. Read more

Supervisors: Prof J Hodge, Dr AF French

12 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

MScR: Cystic fibrosis: restoring ion transport with small molecules

University of Bristol School of Physiology, Pharmacology & Neuroscience

Cystic fibrosis (CF) is caused by dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR), a unique ATP-binding cassette transporter that functions as an ATP-gated anion channel, playing a pivotal role in salt and water movement across epithelial tissues (1). Read more

Supervisor: Prof D N Sheppard

Year round applications PhD Research Project Self-Funded PhD Students Only

MScR - Preserving t-tubule function in adult cardiac myocytes in short-term culture

University of Bristol School of Physiology, Pharmacology & Neuroscience

Invaginations of the sarcolemma of adult cardiac myocytes known as transverse (or t-) tubules account for up to 65% of the total sarcolemma surface and play a key role in excitation-contraction (EC) coupling and cell signalling (Hong & Shaw, 2017). Read more

Supervisors: Prof A James, Dr S Harmer

Year round applications PhD Research Project Self-Funded PhD Students Only

Harnessing the genetics of DNA methylation to understand context-specific gene regulation in disease

University of Bristol Bristol Medical School

Genome wide association studies (GWAS) have discovered many genetic associations for traits and diseases. However, most GWAS signals reside in non-coding regions (outside genes), and it is likely that GWAS variants confer their effects through modulating regulatory mechanism. Read more

Supervisor: Dr J Min

Year round applications PhD Research Project Self-Funded PhD Students Only

Endothelial glycocalyx damage as a therapeutic target in sepsis-associated Acute Kidney Injury

University of Bristol Bristol Medical School

Sepsis is the leading cause of acute kidney injury (sAKI), associated with high morbidity and mortality.1,2 Unfortunately, there is no treatment for sAKI, current therapies are nonspecific and supportive of the vital organ systems in the hope the kidney will recover. Read more

Supervisor: Prof S Satchell

Year round applications PhD Research Project Self-Funded PhD Students Only

Creating patient-specific retinal organoids from human induced pluripotent stem cells for in vitro simulation of uveitis

University of Bristol Bristol Medical School

Uveitis, although uncommon, is a notable cause of visual impairment and blindness. Uveitis encompasses a range of conditions driven by both innate autoinflammatory and adaptive autoimmune CD4 T-cell responses. Read more

Supervisor: Dr P Maghsoudlou

Year round applications PhD Research Project Self-Funded PhD Students Only

Identifying causal risk factors and outcomes of atopic dermatitis

University of Bristol Bristol Medical School

Rationale. Several traits such as cardiovascular disease[1] and mental health disorders[2] have been reported to be observationally associated with atopic dermatitis (AD). Read more

Supervisors: Dr A Budu-Aggrey, Dr L Paternoster

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Investigating the genetic architecture of orofacial cleft: A genome-wide association study using trio data and an investigation of parent of origin and mother-children interaction effects.

University of Bristol Bristol Medical School

Rationale. Orofacial clefts (OFCs) are the most prevalent craniofacial congenital disabilities globally, occurring at a frequency of 1 out of 700 newborns. Read more

Supervisors: Dr S Lewis, Dr E Stergiakouli, Prof H Cordell

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

An investigation of the causal relationship and genetic overlap between sleep traits and physical and mental health using Mendelian randomization

University of Bristol Bristol Medical School

Rationale. Sleep has long been known to play a role in physical and mental wellbeing and sleep disruption has been observed to co-occur with a number of health conditions including. Read more

Supervisors: Dr S Lewis, Dr MR Renteria, Dr HJ Jones

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Identifying causal risk factors for disease progression

University of Bristol Bristol Medical School

Rationale. Typical epidemiological studies aim to identify causal risk factors for onset of disease by comparing diseased cases with disease free controls. Read more

Supervisors: Dr L Paternoster, Prof G Davey-Smith, Dr A Hartley

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Causal risk factors and biological mechanisms for colorectal cancer risk

University of Bristol Bristol Medical School

Rationale. Diet and lifestyle are likely to play an important role in colorectal cancer risk; obesity, low levels of physical activity, red and process meat consumption and low intake of dietary fibre have all been shown to predict colorectal cancer risk. Read more

Supervisors: Dr S Lewis, Dr KT Tsilidis

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Identifying metabolic drivers of cancer development

University of Bristol Bristol Medical School

Rationale. Growing evidence suggests that cell extrinsic factors are key in modulating tumor progression. Metabolites are small molecules that act as sources of fuel and building blocks essential for cells and tissues when present at normal levels. Read more

Supervisors: Dr E Vincent, Dr CB Bull, Prof N Timpson

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Mendelian Randomisation for mediation analysis with multiple mediators: theory and applications

University of Bristol Bristol Medical School

Rationale. Many of an individual’s traits are observationally associated with their health outcomes. Understanding the relationships between these factors is critical to effective public health intervention. Read more

Supervisors: Dr E Sanderson, Dr R Daniel, Dr L Howe

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Evaluating the role of circulating proteins in cancer risk and progression using genetic and observational approaches

University of Bristol Bristol Medical School

Rationale. Circulating proteins play fundamental roles in biology and disease aetiology, including development of cancer, and are the direct targets of many drugs (1). Read more

Supervisors: Prof R Martin, Dr JY Yarmolinsky, Dr P Haycock

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Harnessing genetics of DNA methylation to elucidate molecular mechanisms underlying human phenotypes.

University of Bristol Bristol Medical School

Rationale. GWAS studies have discovered many genetic associations for traits and diseases, but it has been difficult to elucidate the functional consequences of these variants. Read more

Supervisors: Dr J Min, Prof C Relton, Prof J MIll, Dr E Hannon, Dr G Hemani, Prof T Gaunt, Dr B Heijmans, Dr J Bell

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Establishing and orienting causal relationships between sleep characteristics and reproductive function

University of Bristol Bristol Medical School

Rationale. A large body of literature from animal studies has highlighted the role of core clock genes in relation to reproductive function [1]. Read more

Supervisors: Dr R Richmond, Dr G Sharp, Prof D Lawlor

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Breastfeeding and big babies - lifecourse and genomics epidemiological approaches to disentangle cause and effect.

University of Bristol Bristol Medical School

Rationale. The World Health Organisation recommends exclusively breastfeeding for 6 months, but in the UK, only 1% of infants meet the guidelines (1). Read more

Supervisors: Dr L Zuccolo, Dr LJ Johnson, Dr L Howe, Dr C Borges

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Identifying causal pathways to disease using DNA methylation predicted blood traits.

University of Bristol Bristol Medical School

Project Background. Blood cell types have been implicated in pathogenesis of chronic diseases. Genome wide association studies have identified thousands of variants associated with blood trait variation. Read more

Supervisors: Dr J Min, Dr E Hannon, Prof J MIll

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

Investigating the role of dietary fructose in the development of early-onset colorectal cancer

University of Bristol Bristol Medical School

Project Background. This project will investigate the role of fructose in the development of early-onset colorectal cancer (EOCRC) in adults <50 years. Read more

Supervisors: Dr E Vincent, Dr A Chambers, Dr R Richmond, Dr NM Murphy

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

The use of life course epidemiology to support the experimental characterisation of genetic variation

University of Bristol Bristol Medical School

Project Background. There has been a rapid expansion in the generation of genetic sequence data over the last decade. Understanding the potential relevance of genetic mutations to human health remains challenging. Read more

Supervisors: Prof N Timpson, Dr L Corbin, Dr BL Lam

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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