University of Leicester Cell Biology PhD Research Projects PhD Projects, Programmes & Scholarships

We have 21 University of Leicester Cell Biology PhD Research Projects PhD Projects, Programmes & Scholarships

Evaluating the impact of genotoxic aldehyde stress in premature ageing

University of Leicester Department of Chemistry

Aldehydes are highly reactive chemicals that are common pollutants and human metabolites. However, the vast majority of aldehydes’ biological functions are unknown. Read more

Supervisors: Dr R Hopkinson, Dr K Tanaka

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Nuclear and transcriptional dysregulations during cellular senescence

University of Leicester Molecular and Cell Biology

Cellular senescence, which is characterised by a proliferation arrest, is a driver of ageing (1). Several stresses can induce cellular senescence, including persistent DNA damage, telomere dysfunction, and oncogene activation. Read more

Supervisors: Dr MT Tellier, Dr Y Markaki

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Epigenetics of early human development: From molecular mechanisms to regenerative medicine

University of Leicester Molecular and Cell Biology

Ever wondered how nature maintains balance of gene expression between sex chromosomes? Well, the 46th chromosome of XX females, the second X, has to be switched off. Read more

Supervisors: Dr Y Markaki, Dr T Schalch

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Investigating the role of SUMOylation in meiotic recombination and chromosome segregation in Arabidopsis

University of Leicester Department of Genetics and Genome Biology

Research Group: Midlands Integrative Biosciences Training Partnership (MIBTP)

Post-translational modifications of proteins such as phosphorylation, methylation and acetylation have been extensively studied in eukaryotes and now the Small Ubiquitin modifier (SUMO) is gaining attention for its importance in fundamental biological roles. Read more

Supervisors: Dr J Higgins, Dr D Guttery

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Exploring the role of tryptophan metabolism in schizophrenia pathogenesis

University of Leicester Department of Genetics and Genome Biology

L-kynurenine (KYN) and kynurenic acid (KYNA) are metabolites of the kynurenine pathway (KP) of tryptophan degradation and have been found to be increased in the brains of patients with schizophrenia. Read more

Supervisor: Prof F Giorgini

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Structural-guided PROTAC targeting of BMX to modulate apoptotic sensitivity in disease

University of Leicester Molecular and Cell Biology

What determines at the molecular level whether a cell lives or dies? Regulation of the cellular life–death switch is essential in healthy cells for normal foetal development and for the clearance of damaged cells. Read more

Supervisors: Dr JF Fox, Dr JH Hodgkinson

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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The Evolution of Vision in Mosquitoes

University of Leicester Department of Genetics and Genome Biology

Background . Due to their capacity to transmit viruses such as Zika and parasites like Plasmodium (the causative agent of malaria), mosquitos are regarded by the World Health Organization as one of the most lethal organisms on our planet (WHO | Global vector control response 2017–2030, 2020). Read more

Supervisors: Dr R Feuda, Dr E Rosato, Dr B Warren

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Molecular Glues as Novel Tools for Tackling Big Challenges in Human Health

University of Leicester Department of Chemistry

Background. The need for new medicines is greater than ever because of an ageing population and the complex clinical challenges brought about by drug resistance and/or side effects. Read more

Supervisors: Dr RD Doveston, Prof S Macip

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Molecular characterization of Sam68-driven cytoskeletal reorganization

University of Leicester Molecular and Cell Biology

The cytoskeleton is a complex network of various fibres (microtubules, actin, …) that is essential for cells to maintain their shape and internal organization and for their migration. Read more

Supervisors: Dr C Dominguez, Prof A Fry

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Structural and functional characterisation of MALT1 ubiquitination to aid in the development of novel anti-cancer therapies

University of Leicester Molecular and Cell Biology

Nuclear factor-kappa B (NF-kB) is a family of transcription factors that play a crucial role in regulating various cellular processes; primarily related to immune responses, inflammation, and cell survival. Read more

Supervisor: Dr G Hall

Year round applications PhD Research Project Self-Funded PhD Students Only

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Structural and functional analysis of the protein complexes which regulate cell fate decisions to identify novel cancer therapies

University of Leicester Molecular and Cell Biology

Whether a cell dies or not has profound consequences on health and disease. In healthy tissue, cells that acquire high levels of genetic damage are safely removed via a process of programmed cell death. Read more

Supervisor: Dr JF Fox

Year round applications PhD Research Project Self-Funded PhD Students Only

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Transcriptional kinases in cancer and developmental disorders

University of Leicester Molecular and Cell Biology

Cyclin-dependent kinases (CDKs) are protein kinases performing essential functions in regulation of cell cycle and transcription. Read more

Supervisor: Dr MT Tellier

Year round applications PhD Research Project Self-Funded PhD Students Only

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Epigenetics of early human development: From molecular mechanisms to regenerative medicine

University of Leicester Molecular and Cell Biology

The 46th chromosome in XX female mammals, the second X, has to be switched off. That way females equalize gene dosage of X-linked genes with XY males. Read more

Supervisors: Dr Y Markaki, Prof J Schwabe, Dr JH Hodgkinson

Year round applications PhD Research Project Self-Funded PhD Students Only

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Join Our Quest to Unravel the Secrets of Eukaryotic Genomes!

University of Leicester Molecular and Cell Biology

We're on the lookout for passionate PhD students who are eager to delve deep into the mysteries of our DNA. Our quest? To understand the subtle changes that determine how our genes function, both in sickness and in health. Read more

Supervisor: Dr T Schalch

Year round applications PhD Research Project Self-Funded PhD Students Only

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Structural investigation of oncogenic splicing factors

University of Leicester Molecular and Cell Biology

More than 90% of human genes can and do express multiple proteins. This is achieved by a process called alternative RNA splicing, which is an essential step in gene expression in mammals. Read more

Supervisors: Dr C Dominguez, Prof I Eperon, Prof A Hudson

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 21 University of Leicester Cell Biology PhD Research Projects PhD Projects, Programmes & Scholarships

University of Leicester Cell Biology PhD Research Projects PhD Projects, Programmes & Scholarships

We have 21 University of Leicester Cell Biology PhD Research Projects PhD Projects, Programmes & Scholarships

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