We have 34 The University of Manchester Cell Biology PhD Research Projects PhD Projects, Programmes & Scholarships

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The University of Manchester Cell Biology PhD Research Projects PhD Projects, Programmes & Scholarships

We have 34 The University of Manchester Cell Biology PhD Research Projects PhD Projects, Programmes & Scholarships

(MRC DTP CASE) Multiomic evaluation of differential drug response in metastatic breast cancers

The University of Manchester Faculty of Biology, Medicine and Health

Breast cancers are the most common cancers in women. Estrogen Receptor (ER) plays a major role in breast cancer growth. To stop the cancer from growing further, clinically successful ER-targeting therapies like Fulvestrant, etc were developed. Read more

Supervisors: Dr S Nagarajan, Dr HH Harrison, Prof R Clarke, Dr I Iqbal

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

(MRC DTP CASE) Understanding how tumour associated macrophages control the tumour immune landscape in NF2-Schwannomatosis

The University of Manchester Faculty of Biology, Medicine and Health

Type 2 Neurofibromatosis (NF2), now referred to as NF2-Schwannomatosis (or NF2-SWN), is a rare autosomal dominant tumour pre-disposition syndrome characterised by growth of typically benign tumours throughout the nervous system. Read more

Supervisors: Prof D Brough, Dr K Couper

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

Last chance to apply

Repurposing Treg cells for TIL therapy

The University of Manchester Faculty of Biology, Medicine and Health

Tumour-infiltrating lymphocytes (TIL) therapy is an experimental therapy which uses ex-vivo expanded TIL as a source of living drug to treat cancer. Read more

Supervisors: Dr A Hurlstone, Prof M Travis, Prof R Edmondson, Prof F Thistlethwaite

19 April 2024 PhD Research Project Funded PhD Project (UK Students Only)

Assessing the contribution of the human microbiome to paediatric cancer and predisposition and chromosomal instability syndromes

The University of Manchester Faculty of Biology, Medicine and Health

A self-funded PhD studentship is available in the laboratories of Andrew McBain, Stefan Meyer and Chris Knight. The project aims to study the microbiome in paediatric cancer predisposition and chromosomal instability syndromes (CIS). Read more

Supervisors: Prof A McBain, Dr S Meyer, Dr C Knight

Year round applications PhD Research Project Self-Funded PhD Students Only

Peptide-mediated nanocarrier drug delivery for enhanced brain targeting and treatment of inflammation

The University of Manchester Faculty of Biology, Medicine and Health

This project involves the study of nanoparticles and drug delivery to the brain. The student would be required to make and characterise novel nanoparticles from special lipid molecules of various compositions more suitable for blood-brain barrier (BBB) targeting. Read more

Supervisors: Dr HS Shokr, Dr CT Tapeinos, Dr H Aojula

Year round applications PhD Research Project Self-Funded PhD Students Only

How does the dynamic intra-membrane aggregation of phage lysis proteins kill bacterial pathogens?

The University of Manchester Department of Physics and Astronomy

This is an interdisciplinary project. It will provide a unique opportunity to obtain training in a wide range of interdisciplinary skills, including protein engineering techniques, protein purification, atomic force microscopy, neutron reflection and scattering as well as molecular dynamics simulations. Read more

Supervisor: Prof J Lu

28 June 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

Diagnostics for FMF patients and carrier survival in pandemics

The University of Manchester Faculty of Biology, Medicine and Health

Background. Familial Mediterranean Fever (FMF) is a rare inherited genetic disease where patients acquire a mutation on the pyrin gene leading to excessive inflammasome activation and excessive inflammation. Read more

Supervisors: Dr P Arkwright, Dr G Lopez-Castejon, Dr J Cavet

Year round applications PhD Research Project Self-Funded PhD Students Only

Defining the mechanistic basis of Aspergillus fumigatus and Non-tuberculous mycobacteria coinfection

The University of Manchester Faculty of Biology, Medicine and Health

Respiratory infections caused by bacteria, fungi and viruses are a global cause of death according to the WHO. Respiratory coinfections are on the rise and in general linked with poor patient outcomes. Read more

Supervisors: Dr S Gago, Dr CK Kosmidis, Prof L Tabernero

Year round applications PhD Research Project Self-Funded PhD Students Only

Understanding the role of spliceosome gene mutations in disease

The University of Manchester Faculty of Biology, Medicine and Health

The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made. Read more

Supervisors: Prof R O'Keefe, Prof B Newman

Year round applications PhD Research Project Self-Funded PhD Students Only

The epigenomic, transcriptional and diagnostic architecture of neurodevelopmental disorders caused by exposure to maternal infection

The University of Manchester Faculty of Biology, Medicine and Health

A fundamental unknown in understanding mechanisms of disease, and therefore improving therapy, is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult disease (Estes & McAllister 2016). Read more

Supervisors: Dr R Hager, Dr M Harte, Dr J Glazier

Year round applications PhD Research Project Self-Funded PhD Students Only

Cell-matrix interface engineering for regenerative medicine applications and disease modelling

The University of Manchester Faculty of Biology, Medicine and Health

Dr. Mahetab Amer is seeking motivated students with backgrounds in tissue engineering, cell biology, materials science, or related fields to join her dynamic, multidisciplinary research group at the Division of Cell Matrix Biology and Regenerative Medicine, University of Manchester. Read more

Supervisor: Dr M.A Amer

Year round applications PhD Research Project Self-Funded PhD Students Only

Unlocking the potential of plant cellulose for the production of new materials and chemicals

The University of Manchester Faculty of Biology, Medicine and Health

Plant biomass, in the form of plant cell walls are the only renewable resource sufficiently abundant to make a meaningful contribution to decreasing CO. Read more

Supervisors: Prof S Turner, Dr J Pittman

Year round applications PhD Research Project Self-Funded PhD Students Only

Driving phenotypic plasticity and metastasis in small cell lung cancer

The University of Manchester Faculty of Biology, Medicine and Health

Small cell lung cancer (SCLC) is an aggressive malignancy with poor prognosis. Underlying this aggressiveness is intra-tumoural heterogeneity driven by phenotypic plasticity wherein tumour cells transition from a neuroendocrine (NE) to a non-neuroendocrine (non-NE) phenotype. Read more

Supervisors: Prof A Malliri, Dr K Simpson, Prof C Dive

Year round applications PhD Research Project Self-Funded PhD Students Only

Cell-biological mechanisms mediating primary cilium mediated interpretation of Shh signalling during vertebrate neuronal differentiation

The University of Manchester Faculty of Biology, Medicine and Health

Newborn neurons undergo extensive morphological changes as they polarise to extend axons. In the developing spinal cord, newborn neurons extend axons towards their targets in response to cues from the surrounding tissues. Read more

Supervisors: Dr R Das, Dr S Herbert

Year round applications PhD Research Project Self-Funded PhD Students Only

What is the interrelationship between cell mitosis and cell polarity during apical-basal polarisation of epithelial organs?

The University of Manchester Faculty of Biology, Medicine and Health

My group strives to uncover how mechanics and biochemical signalling work together to shape epithelial organs during development. Read more

Supervisors: Dr C.B Buckley, Dr S Woolner

Year round applications PhD Research Project Self-Funded PhD Students Only

Hungry tissues: Understanding how energy metabolism fuels morphogenesis

The University of Manchester Faculty of Biology, Medicine and Health

A vital aspect of multi-cellular life is morphogenesis, the process where the shape and size of an animal emerges from its constituent cells. Read more

Supervisors: Dr J.R.D Davis, Dr T Millard, Dr S Woolner, Prof E Amaya

Year round applications PhD Research Project Self-Funded PhD Students Only

Investigating the connection between early embryo architecture and embryo viability

The University of Manchester Faculty of Biology, Medicine and Health

Include details on the project, outlining the objectives, methods and potential outcomes. Include details of training/techniques to be provided. Read more

Supervisors: Dr B Plusa, Dr K Dorey

Year round applications PhD Research Project Self-Funded PhD Students Only

Investigating WSB-1 as a prognostic marker and therapeutic target in urogenital cancers

The University of Manchester Faculty of Biology, Medicine and Health

Prostate cancer (PCa) is the commonest cancer diagnosed in men, with 5-year survival rates of 60% in those with advanced disease. Read more

Supervisors: Dr IP Monteiro dos Santos Pires, Prof AC Choudhury

Year round applications PhD Research Project Self-Funded PhD Students Only

Control of gene expression in embryonic development

The University of Manchester Faculty of Biology, Medicine and Health

The impressive range of anatomical variations observed in animals along their body axis is the result of distinct control mechanisms governing gene expression. Read more

Supervisors: Prof N Bobola, Dr M Birket

Year round applications PhD Research Project Self-Funded PhD Students Only

Investigating immune contributions to frontotemporal dementia and motor neuron disease

The University of Manchester Faculty of Biology, Medicine and Health

Frontotemporal dementia (FTD) is the 2nd most common form of dementia affecting younger people, with a typical age of onset in the mid-late 50s. Read more

Supervisors: Dr SR Ryan, Prof D Brough

Year round applications PhD Research Project Self-Funded PhD Students Only

Characterisation of how pro-peptide regions of collagen control extracellular matrix homeostasis, in health and musculoskeletal diseases

The University of Manchester Faculty of Biology, Medicine and Health

Collagen-I (‘collagen’ from hereon) is the most abundant protein in the human body (circa 25% of total protein mass), providing structure to organs with very different functions (e.g. Read more

Supervisors: Dr JC Chang, Dr TZ Zacharchenko, Prof C Baldock

Year round applications PhD Research Project Self-Funded PhD Students Only

Identifying critical pathways regulating autoimmunity in immuno-oncology and arthritis patients. Short title: IPADS (Immune PAthways for Drug Side-effects)

The University of Manchester Faculty of Biology, Medicine and Health

Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies (inc. Read more

Supervisors: Dr S Viatte, Prof A Barton, Mr P Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

The role of nuclear localisation of adhesion proteins in tumour growth and invasion

The University of Manchester Faculty of Biology, Medicine and Health

Overview. This project seeks to understand how tumour growth and invasion are controlled by the localisation of certain proteins in cancer cells. Read more

Supervisors: Dr AB Byron, Dr K Finegan, Dr C Tournier

Year round applications PhD Research Project Self-Funded PhD Students Only

Nitrate supplementation in pregnancy: maternal, fetal and offspring outcomes

The University of Manchester Faculty of Biology, Medicine and Health

Maternal diet has a significant impact on fetal growth and development, as well as pregnancy outcomes and long-term offspring health. Dietary patterns… Read more

Supervisors: Dr E Cottrell, Dr M Dilworth

Year round applications PhD Research Project Self-Funded PhD Students Only

Defining the molecular mechanisms of leukaemia chemotherapies

The University of Manchester Faculty of Biology, Medicine and Health

Chemotherapies are usually the backbone of cancer treatment for either curative or palliative patient care. Multiple therapies can be used for the same disease, with the choice of drug dependent on parameters such as the patient’s age and fitness. Read more

Supervisors: Dr JK Knight, Dr K Batta, Dr D Wiseman

Year round applications PhD Research Project Self-Funded PhD Students Only

Chaperones and the response to protein misfolding stress

The University of Manchester Faculty of Biology, Medicine and Health

Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more

Supervisors: Prof C M Grant, Prof M Ashe

Year round applications PhD Research Project Self-Funded PhD Students Only

Investigating the interaction of La related proteins with colliding ribosomes

The University of Manchester Faculty of Biology, Medicine and Health

Translation of mRNA into proteins is a critical cellular biological process for all life. This requires ribosomes to act with an array of translation factors to decode mRNA sequences. Read more

Supervisors: Prof G D Pavitt, Dr A Roseman

Year round applications PhD Research Project Self-Funded PhD Students Only

Graphene oxide as growth factor carriers for meniscus tissue engineering

The University of Manchester Faculty of Biology, Medicine and Health

Damage to the meniscus of the knee leads to increased risk of osteoarthritis. Tissue engineering of a healthy meniscal fibrocartilage offers the opportunity to restore function. Read more

Supervisors: Dr H Lu, Dr S Richardson, Prof P Xiao

Year round applications PhD Research Project Self-Funded PhD Students Only

New strategies to cryopreserve cell-based therapies

The University of Manchester Department of Chemistry

In the past decade, cell-based therapies have emerged to transform the treatment of disease, particularly cancer. Whilst potent, these therapies are challenging to deliver in practise as must be stored frozen (cryopreserved). Read more

Supervisor: Prof m Gibson

Year round applications PhD Research Project Funded PhD Project (UK Students Only)

Identification of transcriptomic signatures of autism-like neurodevelopmental disorder

The University of Manchester Faculty of Biology, Medicine and Health

The overarching aim of this project is to define transcriptional patterns and identify new genetic elements essential for the correct development of the human brain. Read more

Supervisors: Dr PG Grzechnik, Dr A J Whitmarsh

Year round applications PhD Research Project Self-Funded PhD Students Only

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