Cell Biology (genetic analysis) PhD Projects, Programmes & Scholarships

We have 47 Cell Biology (genetic analysis) PhD Projects, Programmes & Scholarships

Identifying causal pathways to disease using DNA methylation predicted blood traits.

University of Bristol Bristol Medical School

Project Background. Blood cell types have been implicated in pathogenesis of chronic diseases. Genome wide association studies have identified thousands of variants associated with blood trait variation. Read more

Supervisors: Dr J Min, Dr E Hannon, Prof J MIll

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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The use of life course epidemiology to support the experimental characterisation of genetic variation

University of Bristol Bristol Medical School

Project Background. There has been a rapid expansion in the generation of genetic sequence data over the last decade. Understanding the potential relevance of genetic mutations to human health remains challenging. Read more

Supervisors: Prof N Timpson, Dr L Corbin, Dr BL Lam

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Genetics: Unravelling the Norrin/beta-catenin signaling pathway and its role in retinal angiogenesis and blindness

University of Leeds Faculty of Medicine and Health

Our previous work on the genetic analysis of individuals with the inherited retinal disease Familial Exudative Vitreoretinopathy (FEVR), has helped identify a new angiogenesis pathway, the Norrin/beta-catenin pathway. Read more

Supervisors: Dr C Toomes, Dr J Bond, Dr S Bell

Year round applications PhD Research Project Self-Funded PhD Students Only

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Mendelian Randomisation for mediation analysis with multiple mediators: theory and applications

University of Bristol Bristol Medical School

Rationale. Many of an individual’s traits are observationally associated with their health outcomes. Understanding the relationships between these factors is critical to effective public health intervention. Read more

Supervisors: Dr E Sanderson, Dr R Daniel, Dr L Howe

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Harnessing the genetics of DNA methylation to understand context-specific gene regulation in disease

University of Bristol Bristol Medical School

Genome wide association studies (GWAS) have discovered many genetic associations for traits and diseases. However, most GWAS signals reside in non-coding regions (outside genes), and it is likely that GWAS variants confer their effects through modulating regulatory mechanism. Read more

Supervisor: Dr J Min

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the genetic architecture of orofacial cleft: A genome-wide association study using trio data and an investigation of parent of origin and mother-children interaction effects.

University of Bristol Bristol Medical School

Rationale. Orofacial clefts (OFCs) are the most prevalent craniofacial congenital disabilities globally, occurring at a frequency of 1 out of 700 newborns. Read more

Supervisors: Dr S Lewis, Dr E Stergiakouli, Prof H Cordell

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Harnessing genetics of DNA methylation to elucidate molecular mechanisms underlying human phenotypes.

University of Bristol Bristol Medical School

Rationale. GWAS studies have discovered many genetic associations for traits and diseases, but it has been difficult to elucidate the functional consequences of these variants. Read more

Supervisors: Dr J Min, Prof C Relton, Prof J MIll, Dr E Hannon, Dr G Hemani, Prof T Gaunt, Dr B Heijmans, Dr J Bell

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Establishing and orienting causal relationships between sleep characteristics and reproductive function

University of Bristol Bristol Medical School

Rationale. A large body of literature from animal studies has highlighted the role of core clock genes in relation to reproductive function [1]. Read more

Supervisors: Dr R Richmond, Dr G Sharp, Prof D Lawlor

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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An investigation of the causal relationship and genetic overlap between sleep traits and physical and mental health using Mendelian randomization

University of Bristol Bristol Medical School

Rationale. Sleep has long been known to play a role in physical and mental wellbeing and sleep disruption has been observed to co-occur with a number of health conditions including. Read more

Supervisors: Dr S Lewis, Dr MR Renteria, Dr HJ Jones

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Evaluating the role of circulating proteins in cancer risk and progression using genetic and observational approaches

University of Bristol Bristol Medical School

Rationale. Circulating proteins play fundamental roles in biology and disease aetiology, including development of cancer, and are the direct targets of many drugs (1). Read more

Supervisors: Prof R Martin, Dr JY Yarmolinsky, Dr P Haycock

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Skeletal Muscle Organoid Models for Genetic Mitochondrial Disease (ref: SF22/HLS/APP/Johnson)

Northumbria University Faculty of Health and Life Sciences

Genetic mitochondrial diseases are both clinically and genetically heterogeneous. Read more

Supervisor: Dr S Johnson

Year round applications PhD Research Project Self-Funded PhD Students Only

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Genetics: Investigating the functional effect of novel genes and genetic variants in malignant hyperthermia susceptibility using model systems

University of Leeds Faculty of Medicine and Health

Malignant hyperthermia (MH) is an inherited condition, where patients exposed to anaesthetic drugs are susceptible to a dramatic hyperthermic and hypermetabolic response that can contribute to a significant proportion of post-operative morbidity and deaths. Read more

Supervisors: Prof P Hopkins, Dr M-A Shaw, Dr C Diggle

Year round applications PhD Research Project Self-Funded PhD Students Only

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A Patient-derived 3D humanized model of ADCY5-related disease to accelerate therapeutic approaches for patients

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

ADCY5-related disease is a genetic disorder caused by mutations in the ADCY5 gene, which encodes for the isoform 5 of adenylyl cyclase (ADCY5)1. Read more

Supervisors: Dr S Barral, Dr M Kurian, Dr HZ Zhou

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam

University of Birmingham School of Biosciences

Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response. Read more

Supervisor: Dr M Soller

Year round applications PhD Research Project Competition Funded PhD Project (Students Worldwide)

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MSc by Research: Analysis of the involvement of mechanosensory system in food search and feeding behaviour

University of Dundee School of Life Sciences

Animals rely on their sensory system to find food and avoid predators. Although olfaction and gustation have been well studied, effect of mechanosensation on food search is underexplored although touch is used frequently in human infants. Read more

Supervisor: Dr V Singh

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 47 Cell Biology (genetic analysis) PhD Projects, Programmes & Scholarships

Cell Biology (genetic analysis) PhD Projects, Programmes & Scholarships

We have 47 Cell Biology (genetic analysis) PhD Projects, Programmes & Scholarships

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