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We have 20 Cell Biology (musculoskeletal) PhD Projects, Programmes & Scholarships

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Cell Biology (musculoskeletal) PhD Projects, Programmes & Scholarships

We have 20 Cell Biology (musculoskeletal) PhD Projects, Programmes & Scholarships

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Development of micro-incubator OCT/ OCE bioreactor system to engineer a robust musculoskeletal tissue model

University of Dundee School of Science and Engineering
Achieving adequate musculoskeletal tissue healing is one of the most challenging factors in the repair of orthopaedic tissues. The problem of hard-to-soft tissue fixation is the major cause of failure of replacement grafts and leads to further musculoskeletal degeneration e.g. Read more
 Supervisors: Dr J Vorstius, Dr C Li
 30 June 2024  PhD Research Project  Self-Funded PhD Students Only
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Musculoskeletal Ageing and Inflammation Research

University of Birmingham School of Biomedical Sciences
We are seeking talented, motivated students with a passion for research in musculoskeletal ageing and chronic inflammatory diseases (e.g., osteoarthritis and sarcopenia) to join the Musculoskeletal Ageing and Inflammation team led by Prof Simon Jones https://www.birmingham.ac.uk/staff/profiles/inflammation-ageing/jones-simon.aspx. Read more
 Supervisor: Dr S Jones
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Characterisation of how pro-peptide regions of collagen control extracellular matrix homeostasis, in health and musculoskeletal diseases

The University of Manchester Faculty of Biology, Medicine and Health
Collagen-I (‘collagen’ from hereon) is the most abundant protein in the human body (circa 25% of total protein mass), providing structure to organs with very different functions (e.g. Read more
 Supervisors: Dr JC Chang, Dr TZ Zacharchenko, Prof C Baldock
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Determination of the non-coding RNAs in the knee joint tissues of dogs at differing risk to cranial cruciate ligament rupture.

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Background. The cranial cruciate ligment (CCL) is the most frequently damaged ligament of the canine knee joint following injuries and age-related ligament breakdown, leading to the development of osteoarthritis (OA). Read more
 Supervisors: Prof E Comerford, Prof M Peffers
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Identifying critical pathways regulating autoimmunity in immuno-oncology and arthritis patients. Short title: IPADS (Immune PAthways for Drug Side-effects)

The University of Manchester Faculty of Biology, Medicine and Health
Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies (inc. Read more
 Supervisors: Dr S Viatte, Prof A Barton, Mr P Martin
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Identifying age-related extracellular microenvironment in dental tissues

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Periodontal disease is the sixth most globally prevalent age-related disease and a leading cause of tooth loss, significantly impacting quality of life and healthy ageing. Read more
 Supervisors: Dr K Yamamoto, Prof FJ Jarad
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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NIHR Leeds BRC: An interferon diagnostic to inform early detection and prevention strategies in Ana positive CTDs

University of Leeds Faculty of Medicine and Health
Type I interferons (IFN) play a role in a wide range of rheumatic and musculoskeletal diseases (RMDs), and strong evidence suggests that measurement of IFN activity could have clinical value, although testing has not progressed into clinical settings. Read more
 Supervisors: Dr F Del Galdo, Dr R Ross
 Open Day(s)  26 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Investigating the regulation of neutrophil gene expression by intracellular signalling and small non-coding RNAs

University of Liverpool Institute of Life Course and Medical Sciences
Immune-mediated inflammatory diseases (IMID) such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) affect millions of people worldwide and cause debilitating and disabling musculoskeletal disease. Read more
 Supervisors: Dr HL Wright, Prof MJ Peffers
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Using pre-clinical models of disease to define new targets to slow joint degeneration in osteoarthritis

University of Liverpool Institute of Life Course and Medical Sciences
The main overall aim of this project is to understand mechanisms of joint degeneration during osteoarthritis progression in order to define new targets for therapy. Read more
 Supervisor: Dr B Poulet
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the role of Aquaporins in age related diseases

University of Liverpool Institute of Life Course and Medical Sciences
Physical frailty, with its associated immobility and disability, is a major factor limiting independence among older people. A key contributor to frailty is a decline in muscle mass and strength (sarcopenia) and the burden of sarcopenia is substantial, with a cost to the NHS of ~£2.5bn/pa. Read more
 Supervisor: Dr C Staunton
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Control of bone shape and function by the extracellular matrix Fibrillin-1

University of Liverpool Institute of Life Course and Medical Sciences
Bones are tightly regulated structures that remodel their structure to adapt to changes in their mechanical environment. With ageing, this mechanical response is often dampened, leading to bone loss and weakness. Read more
 Supervisor: Dr B Poulet
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The effect of low protein diet on the development of the neuromuscular system

University of Liverpool Institute of Life Course and Medical Sciences
Age-related sarcopenia is characterised by reduction in the number of myofibres and motor neurons and an additional weakening of the remaining fibres, causing reduction in muscle mass and function. Read more
 Supervisor: Dr A Vasilaki
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Urokinase-plasminogen activator as a target to block osteoarthritic cartilage destruction

University of Liverpool Institute of Life Course and Medical Sciences
Osteoarthritis (OA) is one of the major causes of disability globally, which is particularly significant in an ageing population. Read more
 Supervisor: Dr D Wilkinson
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The Importance of Muscle Stem Cells: Implications for Muscle Repair in Inflammation and Trauma

University of Nottingham School of Medicine
Skeletal muscle possesses a remarkable capacity for adaptation and repair, processes essential in the maintenance of skeletal muscle health. Read more
 Supervisors: Dr S Joanisse, Prof P Greenhaff, Dr JM Mallinson, Dr C Deane
 30 April 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Understanding how mutations in the kinase TLK2 cause a neurodevelopmental disorder

University of York York Biomedical Research Institute
Tousled-like kinase 2 (TLK2) was recently identified as a novel genetic locus for a neurodevelopmental disorder. Patients predominantly possess de novo mutations in TLK2, leading to a reduction in its expression or kinase activity. Read more
 Supervisors: Dr G Evans, Dr I Hahn
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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