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Cell Biology (risk analysis) PhD Projects, Programmes & Scholarships

We have 26 Cell Biology (risk analysis) PhD Projects, Programmes & Scholarships

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Causal risk factors and biological mechanisms for colorectal cancer risk

University of Bristol Bristol Medical School
Rationale. Diet and lifestyle are likely to play an important role in colorectal cancer risk; obesity, low levels of physical activity, red and process meat consumption and low intake of dietary fibre have all been shown to predict colorectal cancer risk. Read more
 Supervisors: Dr S Lewis, Dr KT Tsilidis
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Evaluating the role of circulating proteins in cancer risk and progression using genetic and observational approaches

University of Bristol Bristol Medical School
Rationale. Circulating proteins play fundamental roles in biology and disease aetiology, including development of cancer, and are the direct targets of many drugs (1). Read more
 Supervisors: Prof R Martin, Dr JY Yarmolinsky, Dr P Haycock
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Machine learning to predict blood function – towards better haematology analysis

University of Reading Department of Biomedical Engineering
Blood represents a complex mixture of blood cells, plasma proteins, hormones, lipids, salts and water. Blood is good indicator of health, and clinically, blood samples are taken frequently to monitor health, risk of disease or success of treatments. Read more
 Supervisors: Prof W Holderbaum, Prof J M Gibbins
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Determination of the non-coding RNAs in the knee joint tissues of dogs at differing risk to cranial cruciate ligament rupture.

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Background. The cranial cruciate ligment (CCL) is the most frequently damaged ligament of the canine knee joint following injuries and age-related ligament breakdown, leading to the development of osteoarthritis (OA). Read more
 Supervisors: Prof E Comerford, Prof M Peffers
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Using single cell transcriptomic and blood proteomic data to understand how pancreatic cancer causes diabetes and to find ways to detect the cancer earlier

University of Liverpool Department of Molecular and Clinical Cancer Medicine
Pancreatic cancer is the deadliest of the common cancers. Five-year survival remains low at 12%. Sadly for 80% of patients, by the time their cancer is diagnosed it has spread to distant organs making them ineligible for potentially curative surgery. Read more
 Supervisor: Prof E Costello
 23 May 2024  PhD Research Project  Self-Funded PhD Students Only
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Identifying causal pathways to disease using DNA methylation predicted blood traits.

University of Bristol Bristol Medical School
Project Background. Blood cell types have been implicated in pathogenesis of chronic diseases. Genome wide association studies have identified thousands of variants associated with blood trait variation. Read more
 Supervisors: Dr J Min, Dr E Hannon, Prof J MIll
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Microplastics and Nanoplastics as Emerging Risk Factors in Neurodevelopmental and Neurodegenerative Condition

University of Reading Department of Biomedical Sciences
Project Overview. Microplastics (MPs) and nanoplastics (NPs) are ubiquitous environmental pollutants raising concerns due to their potential adverse effects on human health. Read more
 Supervisor: Dr E Kevei
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Identifying causal risk factors and outcomes of atopic dermatitis

University of Bristol Bristol Medical School
Rationale. Several traits such as cardiovascular disease[1] and mental health disorders[2] have been reported to be observationally associated with atopic dermatitis (AD). Read more
 Supervisors: Dr A Budu-Aggrey, Dr L Paternoster
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Treatment and biomarker development for inherited manganese transporter defects using cell models of SLC30A10 deficiency

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships
Manganese is essential to human health and development. However, excess manganese is neurotoxic causing manganism, a neurodegenerative disorder characterised by dystonia-parkinsonism. Read more
 Supervisors: Dr K Tuschl, Dr P Mills, Dr WH Heywood
 15 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Harnessing genetics of DNA methylation to elucidate molecular mechanisms underlying human phenotypes.

University of Bristol Bristol Medical School
Rationale. GWAS studies have discovered many genetic associations for traits and diseases, but it has been difficult to elucidate the functional consequences of these variants. Read more
 Supervisors: Dr J Min, Prof C Relton, Prof J MIll, Dr E Hannon, Dr G Hemani, Prof T Gaunt, Dr B Heijmans, Dr J Bell
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Clinical Gastroenterology: Investigation of Fidaxomicin Resistance Mechanisms in Clostridium difficile

University of Leeds Faculty of Medicine and Health
Clostridium difficile is a leading pathogen in healthcare-associated diarrheal infections. C. difficile has a plastic genome with multiple mobile genetic elements and recognized capacity to acquire genes involved in resistance and virulence. Read more
 Supervisors: Prof M Wilcox, Prof A O'Neill, Dr J Freeman, Dr I Moura
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Metabolic programming: Role of micronutrient (B12) deficiency and associated epigenetic marks

Nottingham Trent University School of Science & Technology
The global epidemic of childhood obesity is a major public health issue. Although current adverse lifestyle (nutrition and physical inactivity) contributes to obesity, a growing body of evidence links early life nutritional adversity to the development of obesity and metabolic disorders in children. Read more
 Supervisor: Dr A Antonysunil
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the genetic architecture of orofacial cleft: A genome-wide association study using trio data and an investigation of parent of origin and mother-children interaction effects.

University of Bristol Bristol Medical School
Rationale. Orofacial clefts (OFCs) are the most prevalent craniofacial congenital disabilities globally, occurring at a frequency of 1 out of 700 newborns. Read more
 Supervisors: Dr S Lewis, Dr E Stergiakouli, Prof H Cordell
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Skeletal Muscle Organoid Models for Genetic Mitochondrial Disease (ref: SF22/HLS/APP/Johnson)

Northumbria University Faculty of Health and Life Sciences
Genetic mitochondrial diseases are both clinically and genetically heterogeneous. Read more
 Supervisor: Dr S Johnson
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Ageing to Arrhythmias

University of Leeds Faculty of Biological Sciences
Cardiac arrhythmias are a leading cause of sudden death and morbidity. This project aims to identify why they occur in the elderly and novel routes to therapies. Read more
 Supervisors: Dr M K Lancaster, Dr M.A. Colman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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