University of Dundee Cancer Biology PhD Projects, Programmes & Scholarships

We have 9 University of Dundee Cancer Biology PhD Projects, Programmes & Scholarships

Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation

University of Dundee School of Life Sciences

Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more

Supervisors: Prof G Sapkota, Dr S Virdee

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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MSc by Research: Investigating the tumor suppressor functions of chromatin remodelling

University of Dundee School of Life Sciences

One of the unanticipated outcomes of population based genome sequencing has been the finding that genes involved in the regulation of many genes are mutated at high frequency in tissue specific cancers. Read more

Supervisor: Prof T A Owen-hughes

Year round applications PhD Research Project Self-Funded PhD Students Only

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MSc by Research: Monitoring and manipulating kinase activity in stem cells

University of Dundee School of Life Sciences

Posttranslational modifications of proteins are important regulatory events that impact most if not all physiological functions of cells. Read more

Supervisor: Dr J Januschke

Year round applications PhD Research Project Self-Funded PhD Students Only

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MSc by Research: Using genome editing to study the mechanisms of immune cell proliferation and differentiation

University of Dundee School of Life Sciences

T lymphocytes mediate long-term adaptive immunity to viruses and tumour cells. T lymphocytes recognize foreign antigens via specific interactions with the T cell receptor (TCR) that is expressed on the cell surface. Read more

Supervisor: Dr T Ly

Year round applications PhD Research Project Self-Funded PhD Students Only

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MSc by Research: Targeted protein post-translational modification to rewire cell signalling

University of Dundee School of Life Sciences

Post-translational modifications (PTMs) of proteins, such as ubiquitylation and phosphorylation, are fundamental determinants of protein function and cellular signalling. Read more

Supervisors: Prof G Sapkota, Dr S Virdee

Year round applications PhD Research Project Self-Funded PhD Students Only

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MSc by Research: How are SUMO substrates selected for modification ?

University of Dundee School of Life Sciences

SUMO has diverse roles in cellular physiology that in most cases are mediated by its ability to interact non-covalently with hydrophobic patches of low sequence complexity known as SUMO Interaction Motifs (SIMs). Read more

Supervisor: Prof R Hay

Year round applications PhD Research Project Self-Funded PhD Students Only

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MSc by Research: Regulation and mechanics in polarized trafficking

University of Dundee School of Life Sciences

Membranes and their protein organization are a frontier in our understanding of cell biology. We focus on polarized trafficking as a model to uncover fundamental mechanisms in the organization of structures at membranes. Read more

Supervisor: Dr D H Murray

Year round applications PhD Research Project Self-Funded PhD Students Only

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MSc by Research: Understanding the functions of ERphagy via its targeted cargos

University of Dundee School of Life Sciences

The selective degradation of the endoplasmic reticulum via autophagy, also known as ERphagy, is a fundamental cellular process that has been observed under different stresses and stimuli. Read more

Supervisor: Dr JRL Liang

Year round applications PhD Research Project Self-Funded PhD Students Only

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Developing novel targeted therapeutic approaches through induced-proximity of proteins

University of Dundee School of Life Sciences

Protein post-translational code is at the heart of protein function and signal transduction in cells. Enzymes catalyse the addition or removal of post-translational modifications (PTM), such as phosphorylation, methylation, acetylation, and ubiquitylation, on proteins. Read more

Supervisors: Prof G Sapkota, Prof A Ciulli

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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We have 9 University of Dundee Cancer Biology PhD Projects, Programmes & Scholarships

University of Dundee Cancer Biology PhD Projects, Programmes & Scholarships

We have 9 University of Dundee Cancer Biology PhD Projects, Programmes & Scholarships

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