University of Leeds Cancer Biology PhD Research Projects PhD Projects, Programmes & Scholarships

We have 31 University of Leeds Cancer Biology PhD Research Projects PhD Projects, Programmes & Scholarships

Translational Medicine: Understanding the mechanism(s) of resistance to EPA to personalise therapy and improve outcome

University of Leeds Faculty of Medicine and Health

Advanced colorectal cancer (CRC) is the UK’s second most lethal cancer, with limited treatment options for unresectable metastatic tumours. Read more

Supervisors: Dr MA Volpato, Prof M Hull

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cancer Biology: The role of Wnt signaling in glioblastoma therapeutic resistance

University of Leeds Faculty of Medicine and Health

Glioblastoma is a deadly brain tumour treated with surgery, radiotherapy and chemotherapy with patient survival of 6-15 months. Read more

Supervisors: Dr G Mavria, Dr S Bell, Dr C Toomes

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cancer: Understanding the immunosuppressive role of fibroblast and macrophages in Breast cancer

University of Leeds Faculty of Medicine and Health

Oncolytic viruses (OVs) preferentially infect and kill cancer cells, and their clinical efficacy has been demonstrated against a number of different cancers. The most clinically advanced OV is a genetically engineered herpes simplex virus (T-VEC) which expresses GMCSF to aid the development of anti-tumour immune responses; T-VEC is approved for the treatment of metastatic melanoma. Read more

Supervisors: Dr F Errington-Mais, Dr V Jennings

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cancer: Complex 3D modelling of the tumour microenvironment for immunotherapy combination screening

University of Leeds Faculty of Medicine and Health

Cancer immunotherapy holds significant promise for the treatment of a range of cancers. Read more

Supervisors: Dr MA Volpato, Dr F Errington-Mais

Year round applications PhD Research Project Self-Funded PhD Students Only

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Haematology: Oncogenic mechanisms causing malignant transformation of B cells and plasma cells

University of Leeds Faculty of Medicine and Health

Cancers of B cells and plasma cells, lymphomas and multiple myeloma, can be very aggressive, and often the cancer rapidly reoccurs after standard therapy. Read more

Supervisor: Prof U Klein

Year round applications PhD Research Project Self-Funded PhD Students Only

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Virology: Unique Antiviral Therapy targeting Zika and Related Viruses

University of Leeds Faculty of Medicine and Health

Zika Virus (ZIKV) has emerged as a new mosquito-borne threat to public health after the devastating South American outbreak. Read more

Supervisors: Dr S Griffin, Dr A Kalli, Dr C McKimmie

Year round applications PhD Research Project Self-Funded PhD Students Only

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Virology: Sun exposure as a novel risk factor for Zika virus infection

University of Leeds Faculty of Medicine and Health

Mosquito-borne disease is now receiving unprecedented attention due to major outbreaks in new geographic areas including Brazil, Mexico, India, China, the Middle East and SE Asia. Read more

Supervisors: Dr C McKimmie, Dr K Shams, Dr S Griffin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Immunotherapy: Manipulating T cell metabolism to improve anti-tumour immunity

University of Leeds Faculty of Medicine and Health

The induction of immune responses to tumours can provide long-lasting protection from cancer. In this regard, T cells can suppress tumour growth by directly killing cancer cells and by producing inflammatory cytokines. Read more

Supervisors: Dr M Lorger, Dr R Salmond

Year round applications PhD Research Project Self-Funded PhD Students Only

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Immunotherapy: Killing Cancer using Dead Virus

University of Leeds Faculty of Medicine and Health

It is now accepted that our immune systems can hold the key to treating otherwise incurable cancers. So-called “immunotherapy” is an increasingly common method of treating tumours, leading to impressive increases in patient responses. . Read more

Supervisors: Dr S Griffin, Dr A Samson

Year round applications PhD Research Project Self-Funded PhD Students Only

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Haematology: Oncogenic reprogramming of immune cells

University of Leeds Faculty of Medicine and Health

Under pathogenic challenges, cells of the innate system become epigenetically reprogrammed and establish immune memory. Read more

Supervisors: Dr F Errington-Mais, Dr P Laslo

Year round applications PhD Research Project Self-Funded PhD Students Only

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Clinical: Gastroesophageal reflux in respiratory disease: pathogenic role and improved management

University of Leeds Faculty of Medicine and Health

Gastroesophageal reflux disease (GERD) is a condition in which stomach contents, such as food and acid pass into the gullet/oesophagus causing heartburn. GERD is very common in patients with lung disease, such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Read more

Supervisors: Prof L Houghton, Dr D Peckham

Year round applications PhD Research Project Self-Funded PhD Students Only

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Clinical Gastroenterology: The regulation of GDH expression in Clostridioides difficile

University of Leeds Faculty of Medicine and Health

Clostridioides difficile infection (CDI), the most common cause of infective antibiotic-associated diarrhea in the western world, is diagnosed by a combination of tests that firstly detect the organism, then the toxins that it produces (Planche 2013). Read more

Supervisors: Prof M Wilcox, Dr K Davies, Dr A Buckley

Year round applications PhD Research Project Self-Funded PhD Students Only

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Clinical Gastroenterology: Investigation of Fidaxomicin Resistance Mechanisms in Clostridium difficile

University of Leeds Faculty of Medicine and Health

Clostridium difficile is a leading pathogen in healthcare-associated diarrheal infections. C. difficile has a plastic genome with multiple mobile genetic elements and recognized capacity to acquire genes involved in resistance and virulence. Read more

Supervisors: Prof M Wilcox, Prof A O'Neill, Dr J Freeman, Dr I Moura

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cancer: Why and how do brain tumour cells invade ‘mini-brains’?

University of Leeds Faculty of Medicine and Health

Globally, nearly 189,000 people die each year as a result of brain cancer and around 250,000 people are diagnosed with a malignant brain tumour (umbrella name. Read more

Supervisors: Dr H Wurdak, Dr R Mathew

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cancer: Repurposing drugs as new treatments for breast cancer

University of Leeds Faculty of Medicine and Health

Breast cancer (BC) is the most common cancer, with over 1 million new cases diagnosed worldwide each year. For some types of BC, hormonal treatments have been very effective but one particular BC subtype, triple negative breast cancer (TNBC), is highly aggressive and lacks a targeted therapy. Read more

Supervisors: Dr L Matthews, Dr P Meakin

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 31 University of Leeds Cancer Biology PhD Research Projects PhD Projects, Programmes & Scholarships

University of Leeds Cancer Biology PhD Research Projects PhD Projects, Programmes & Scholarships

We have 31 University of Leeds Cancer Biology PhD Research Projects PhD Projects, Programmes & Scholarships

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