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We have 22 Cancer Biology (drug resistance) PhD Projects, Programmes & Scholarships

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Cancer Biology (drug resistance) PhD Projects, Programmes & Scholarships

We have 22 Cancer Biology (drug resistance) PhD Projects, Programmes & Scholarships

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Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working. Read more
 Supervisors: Dr S Shnyder, Dr S Kantamneni
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The role of vitamin D3 in treating skin cancer and preventing drug resistance

University of Bradford Faculty of Life Sciences
  Research Group: Chemistry and Biosciences
During the last decade numerous studies have alluded to vitamin D. 3. playing a role in the prevention of cancer. Recent clinical trials looking at the potential role of vitamin D. Read more
 Supervisors: Dr M Sutherland, Dr H Sheldrake, Dr S Kauser
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Haematology: Oncogenic reprogramming of immune cells; novel mechanism for drug resistance in leukaemia

University of Leeds Faculty of Medicine and Health
Under pathogenic challenges, cells of the haematopoietic system become epigenetically reprogrammed and establish immune memory. Read more
 Supervisor: Dr P Laslo
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating how dormant senescent cells can drive drug-resistance following chemotherapy

University of Dundee School of Medicine
Most anti-cancer chemotherapeutics work by inducing DNA damage and arresting the cell cycle in either G1 or G2 phase. A frequent outcome of this arrest is that cells exit the cell cycle into a state known as senescence. Read more
 Supervisors: Dr A Saurin, Dr T Ly
 30 June 2024  PhD Research Project  Self-Funded PhD Students Only
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Haematology: Oncogenic reprogramming of immune cells

University of Leeds Faculty of Medicine and Health
Under pathogenic challenges, cells of the innate system become epigenetically reprogrammed and establish immune memory. Read more
 Supervisors: Dr F Errington-Mais, Dr P Laslo
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Nanotechnologies for cancer: developing new polymer-drug conjugates for the treatment of a range of cancers

University of Reading School of Pharmacy
Polymer anticancer-drug conjugates are drug delivery systems in which a low molecular weight anticancer agent is covalently conjugated to a water-soluble polymeric carrier. Read more
 Supervisors: Dr F Greco, Prof H Osborn
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Fully funded PhD studentship in mechanisms of cancer heterogeneity and drug sensitivity

Ariel University Department of Molecular Biology
Treatment of cancer with drugs that cause DNA damage often leads to development of the drug tolerance. Recently, we uncovered a novel mechanism of such an adaptation that associates with active generation of hundreds of thousand mutations in chromosomes that prevent drug-triggered DNA damage. Read more
 Supervisor: Prof M Sherman
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Investigating the impact of galectin-ligand interaction on cancer cell resistance to chemotherapeutic treatment

University of Liverpool Institute of Life Course and Medical Sciences
Galectins are multifunctional carbohydrate-binding proteins that are expressed by many types of human cells. Changes of galectin expression commonly occur in cancer (e.g. Read more
 Supervisor: Prof LG Yu
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Clinical Gastroenterology: Investigation of Fidaxomicin Resistance Mechanisms in Clostridium difficile

University of Leeds Faculty of Medicine and Health
Clostridium difficile is a leading pathogen in healthcare-associated diarrheal infections. C. difficile has a plastic genome with multiple mobile genetic elements and recognized capacity to acquire genes involved in resistance and virulence. Read more
 Supervisors: Prof M Wilcox, Prof A O'Neill, Dr J Freeman, Dr I Moura
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Multilevel selection on transposition rates in cancer

University of Reading Department of Ecology and Evolutionary Biology
Cancer is an evolutionary process. Cells in a tumour vary due to mutation, and so over many generations they adapt in response to both intrinsic selective pressures (such as anoxia) and extrinsic selective pressures (such as chemotherapy). Read more
 Supervisor: Dr L J Johnson
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Translational Medicine: Understanding the mechanism(s) of resistance to EPA to personalise therapy and improve outcome

University of Leeds Faculty of Medicine and Health
Advanced colorectal cancer (CRC) is the UK’s second most lethal cancer, with limited treatment options for unresectable metastatic tumours. Read more
 Supervisors: Dr MA Volpato, Prof M Hull
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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(MRC DTP CASE) Multiomic evaluation of differential drug response in metastatic breast cancers

The University of Manchester Faculty of Biology, Medicine and Health
Breast cancers are the most common cancers in women. Estrogen Receptor (ER) plays a major role in breast cancer growth. To stop the cancer from growing further, clinically successful ER-targeting therapies like Fulvestrant, etc were developed. Read more
 Supervisors: Dr S Nagarajan, Dr HH Harrison, Prof R Clarke, Dr I Iqbal
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Vascularisation of tumour organoids for mechanistic and drug development

University of Dundee School of Medicine
Gliomas such as are the most common form of brain tumour, a subset Glioblastoma (GBM) are devastating adult brain cancer with high rates of recurrence and treatment resistance. Read more
 Supervisors: Dr C Murdoch, Dr S Banerjee
 30 June 2024  PhD Research Project  Self-Funded PhD Students Only
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Harnessing Breast Cancer Therapy: Innovative Formulation Strategies for Repurposing Medicines to Overcome Resistance

Kingston University Faculty of Health, Science, Social Care and Education
Background. Research in the Kadri group focuses on developing innovative chemical approaches for the discovery of novel therapeutics to address unmet global health needs. Read more
 Supervisor: Dr H Kadri
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Transcriptome biomarkers and mechanisms of chemoresistance

Queen Mary University of London Institute of Dentistry
Project Summary. This project aims to identify biomarkers linked to the most potent multimodal anticancer therapy with the least toxicity to counteract hemoresistance in head and neck squamous cell carcinoma (HNSCC). Read more
 Supervisor: Dr M T Teh
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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