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We have 15 Cancer Biology (enzymes) PhD Projects, Programmes & Scholarships

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Cancer Biology (enzymes) PhD Projects, Programmes & Scholarships

We have 15 Cancer Biology (enzymes) PhD Projects, Programmes & Scholarships

The role of ubiquitin-modifying enzymes in angiogenesis

The School of Molecular & Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

Developing novel targeted therapeutic approaches through induced-proximity of proteins

Protein post-translational code is at the heart of protein function and signal transduction in cells. Enzymes catalyse the addition or removal of post-translational modifications (PTM), such as phosphorylation, methylation, acetylation, and ubiquitylation, on proteins. Read more

Discovery and profiling of small-molecule inhibitors of cellular nuclease enzymes

Nuclease enzymes are non-traditional drug targets that attract an increasing amount of interest as potential targets relevant for a variety of therapeutic areas including infection, cancer and bone disease. Read more

Mechanisms controlling gene expression in hypoxia and inflammation

Oxygen is one of the most important molecules for life. Every member of the animal kingdom depends on oxygen to help metabolize its food and drive many critical processes in metabolism. Read more

The clinical and therapeutic impact of disialoganglioside GD2 and its synthases on breast cancer

Disialoganglioside GD2 is a plasma membrane member of the large glycosphingolipid family which involves a hydrophobic ceramide bound to a hydrophilic sialic acid-containing glycan chain. Read more

MSc by Research: Investigating the tumor suppressor functions of chromatin remodelling

One of the unanticipated outcomes of population based genome sequencing has been the finding that genes involved in the regulation of many genes are mutated at high frequency in tissue specific cancers. Read more

Understanding gene regulation by HDAC1 complexes in development and cancer

Packaging DNA into nucleosomes helps protect the long fragile genomes of eukaryotic species. However, in doing so it becomes an ever-present physical barrier to the machinery required for its replication, repair and transcription. Read more

Biophysical explorations of neural crest cell behaviours in development and cancer

Neural crest cells are highly migratory. These cells travel throughout the developing embryo, eventually contributing to most organ systems, including the peripheral nervous system, pigment cells and craniofacial skeleton. Read more

Inducing ferroptotic death to kill cancer cells

Ferroptosis is an iron-dependent form of regulated necrotic cell death triggered by oxidative degradation of lipids in membrane bilayers and subsequent irreparable damages to the plasma membrane (1). Read more
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