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We have 45 Biochemistry PhD Research Projects PhD Projects, Programmes & Scholarships in Manchester

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Biological Sciences

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Manchester  United Kingdom

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Biochemistry PhD Research Projects PhD Projects, Programmes & Scholarships in Manchester

We have 45 Biochemistry PhD Research Projects PhD Projects, Programmes & Scholarships in Manchester

Where has all of the carbon gone? Understanding the molecular mechanisms of long-term soil carbon capture

Soils, while unglamorous, form the basis of the terrestrial biosphere and are ultimately the source of the majority of the food that we eat, yet fundamental aspects of how soils form and how they store carbon are poorly understood. Read more

Chaperones and the response to protein misfolding stress

Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more

High-throughput characterization and engineering of nucleotide synthases for production of nucleoside analogues

Nucleotides are the building blocks of life, modulating diverse processes from protein production to cell signalling. It is therefore unsurprising that synthetic nucleoside analogues have been developed as therapeutics for the treatment of a wide range of diseases including cancers and viral infections. Read more

How does the dynamic intra-membrane aggregation of phage lysis proteins kill bacterial pathogens?

This is an interdisciplinary project. It will provide a unique opportunity to obtain training in a wide range of interdisciplinary skills, including protein engineering techniques, protein purification, atomic force microscopy, neutron reflection and scattering as well as molecular dynamics simulations. Read more
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Enzyme Cascades controlled in the Electrochemical Leaf for Discovery in Antimicrobial Strategy

Antibiotic discovery is usually aimed at single entities, for example a bacterial enzyme or efflux protein. This also means that antimicrobial resistance (AMR) mechanisms are considered in terms of the individual response, for example, mutations in a single target enzyme, affording resistance to the drug. Read more

Driving phenotypic plasticity and metastasis in small cell lung cancer

Small cell lung cancer (SCLC) is an aggressive malignancy with poor prognosis. Underlying this aggressiveness is intra-tumoural heterogeneity driven by phenotypic plasticity wherein tumour cells transition from a neuroendocrine (NE) to a non-neuroendocrine (non-NE) phenotype. Read more

Taking Light Induced Electron Paramagnetic Resonance In Cell for Biological Structural Determination

Studying the structure of proteins and other biological systems is an important step in understanding their function. Most structural studies are conducted in environments that are far away from native conditions, such as those found inside a cell. Read more

Diabetic Foot Ulcer

PROJECT ADVERT. The management of chronic wounds poses a considerable burden on healthcare systems, with approximately 2.2 million patients currently afflicted, resulting in annual costs of £5.3 billion for the NHS to address wound care and its associated comorbidities, including amputations. Read more

(MRC DTP CASE) Understanding how tumour associated macrophages control the tumour immune landscape in NF2-Schwannomatosis

Type 2 Neurofibromatosis (NF2), now referred to as NF2-Schwannomatosis (or NF2-SWN), is a rare autosomal dominant tumour pre-disposition syndrome characterised by growth of typically benign tumours throughout the nervous system. Read more

Reducing health inequalities and improving rehabilitation services in Greater Manchester (ACCESS4ALL)

Project advert. Rehabilitation services prove highly effective in managing numerous chronic conditions such as coronary artery disease, yet they remain underutilized among patients. Read more

Alternative Materials and Processes for the Textile and Fashion Industry

The fashion and textile industries conduct some of the most polluting practices on the planet. Many initiatives are striving to positively impact the issues the industry faces, in line with climate targets and UN sustainable development goals. Read more

Understanding the role of spliceosome gene mutations in disease

The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made. Read more

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