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We have 17 University of Bradford Biochemistry PhD Projects, Programmes & Scholarships

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University of Bradford Biochemistry PhD Projects, Programmes & Scholarships

We have 17 University of Bradford Biochemistry PhD Projects, Programmes & Scholarships

University of Bradford

Making Knowledge Work at the University of Bradford

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Mechanisms underlying the effects of activated protein C (APC) in cardiac muscle

University of Bradford Faculty of Life Sciences
  Research Group: Chemistry and Biosciences
APC is an anticoagulant enzyme that also exerts antithrombotic, anti-inflammatory, antiapoptotic and a variety of other cytoprotective effects in different tissues, where the mechanism of action is thought to involve the endothelial protein C receptor (EPCR) and a protease activated receptor (PAR). Read more
 Supervisors: Dr M Hussain, Dr T Nasim, Prof MR Boyett
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Characterisation of adrenoceptor and muscarinic receptor subtypes coupled to potassium channels in chondrocytes from bovine cartilage

University of Bradford Faculty of Life Sciences
  Research Group: Chemistry and Biosciences
Several outward potassium currents have been identified in bovine chondrocytes (review Mobasheri et al. 2012). These include ATP-sensitive and a Calcium-activated potassium currents (Sanches & Lopez-Zapata, 2011). Read more
 Supervisors: Dr M Hussain, Dr M Katsikogianni, Dr N Javid
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Beat-to-beat modulation of Calcium-induced Calcium release in cardiac muscle

University of Bradford Faculty of Life Sciences
  Research Group: Chemistry and Biosciences
Contraction in the heart is well known to be dependent on a transient rise in intracellular calcium concentration. Read more
 Supervisors: Dr M Hussain, Dr J Muller, Prof MR Boyett
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Therapeutic resolution of pulmonary arterial hypertension (PAH) by natural products

University of Bradford Faculty of Life Sciences
  Research Group: Pharmacology and Experimental Therapeutics
Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death. Read more
 Supervisors: Dr T Nasim, Prof C Wright
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Therapeutic resolution of coronavirus (COVID-19) diseases by natural products

University of Bradford Faculty of Life Sciences
  Research Group: Pharmacology and Experimental Therapeutics
Coronavirus now labelled as Covid-19 has become a global pandemic affecting around 200 countries. Currently neither any cure nor any vaccine for Covid-19 has been established. Read more
 Supervisor: Dr T Nasim
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Polysialyltransferases as a target in metastatic cancer

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases. Read more
 Supervisors: Prof R Falconer, Dr S Shnyder
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Nanoparticle synthesis and application in magnetic field hyperthermia for cancer therapy

University of Bradford Faculty of Life Sciences
  Research Group: Chemistry and Biosciences
Magnetic field hyperthermia (MFH) is currently undergoing clinical trials for use in humans. The research to date has shown the effectiveness of the approach in cells and animal models and the initial results from human trials are promising. Read more
 Supervisors: Dr P Drake, Dr S Shnyder
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigation of the extracellular matrix as a regulator of Parkinson’s progression

University of Bradford Faculty of Life Sciences
  Research Group: Chemistry and Biosciences
Parkinson’s is the 2nd most common neurodegenerative disease, affecting around 1 in 20 people aged over 65. In the UK, the number of affected people is set to rise by 50% over the next 50 years due to ageing populations. Read more
 Supervisor: Dr SM Dickens
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigation of antagonism of multiple RGD-binding integrins as a therapeutic strategy in advanced head and neck cancer

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Background. The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis. Read more
 Supervisor: Dr H Sheldrake
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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How effective is 3D reconstructed human skin as an alternative to human skin for permeation studies?

University of Bradford Faculty of Life Sciences
The assessment of percutaneous absorption of molecules is a very important step in the evaluation of any transdermal drug delivery system. Read more
 Supervisors: Dr X Liu, Dr M Isreb
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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ERK5 MAPK signalling in Alzheimer’s disease

University of Bradford Faculty of Life Sciences
  Research Group: Pharmacology and Experimental Therapeutics
Neurodegenerative diseases have devastating effects on individuals’ lives and our society, with no effective treatments available. Read more
 Supervisors: Dr J Muller, Dr S Kantamneni
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Development of chemical tools and bioactive compounds to explore the importance of enzyme activity in cancer diseases

University of Bradford Faculty of Life Sciences
Diversity-oriented synthesis (DOS) is a modern chemical methodology, which aims to synthesise small molecules that cover new chemical space with the possibility of finding unexplored biological targets or pathways that may be important for disease progression. Read more
 Supervisors: Prof K Pors, Dr V Vangala
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Development of a personalized therapy for pulmonary arterial hypertension (PAH)

University of Bradford Faculty of Life Sciences
  Research Group: Pharmacology and Experimental Therapeutics
Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death. Read more
 Supervisor: Dr T Nasim
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more
 Supervisors: Prof R Falconer, Prof P Loadman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more
 Supervisors: Prof R Falconer, Dr S Shnyder
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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