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We have 42 The University of Manchester Biochemistry PhD Projects, Programmes & Scholarships

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The University of Manchester Biochemistry PhD Projects, Programmes & Scholarships

We have 42 The University of Manchester Biochemistry PhD Projects, Programmes & Scholarships

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Understanding the role of spliceosome gene mutations in disease

The University of Manchester Faculty of Biology, Medicine and Health
The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made. Read more
 Supervisors: Prof R O'Keefe, Prof B Newman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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(University of Manchester - University of Tokyo Dual Award) Diversifying Antitumor Drugs through the Integration of Synthetic Biology and Chemo-enzymatic Approaches

The University of Manchester Department of Chemistry
Ecteinascidin 743 (ET-743, Trabectedin) is a marine-derived natural organic compound approved for the treatment of soft tissue sarcomas. Read more
 Supervisors: Prof E Takano, Prof H Oguri
 29 April 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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New Methods for modelling cofactor-dependent enzyme structure and function

The University of Manchester Department of Chemistry
Enzymes are Nature’s catalysts and many used cofactors and/or coenzymes to catalyse their reactions. While AI and homology methods now often allow the useful prediction of protein structure from amino acid sequence, this can be more challenging when the protein/enzyme contain cofactors. Read more
 Supervisor: Prof S Hay
 27 October 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Characterising human sebum using NMR approaches

The University of Manchester Department of Chemistry
We have recently shown that skin secretions in particular sebum, has a critical diagnostic role in other diseases unrelated directly to the skin. Read more
 Supervisors: Dr D K Trivedi, Prof M Nilsson, Prof GA Morris
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Synthetic and Mechanistic Studies into Enzymatic Degradation of Waste Plastics

The University of Manchester Department of Chemistry
Plastics are a broad range of solid polymeric materials that have found widespread application globally. However, there has been a steady accumulation of discarded plastics and there is now growing awareness that they present a significant hazard to the natural environment and human health. Read more
 Supervisor: Dr L Wong
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Unlocking the potential of plant cellulose for the production of new materials and chemicals

The University of Manchester Faculty of Biology, Medicine and Health
Plant biomass, in the form of plant cell walls are the only renewable resource sufficiently abundant to make a meaningful contribution to decreasing CO. Read more
 Supervisors: Prof S Turner, Dr J Pittman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Driving phenotypic plasticity and metastasis in small cell lung cancer

The University of Manchester Faculty of Biology, Medicine and Health
Small cell lung cancer (SCLC) is an aggressive malignancy with poor prognosis. Underlying this aggressiveness is intra-tumoural heterogeneity driven by phenotypic plasticity wherein tumour cells transition from a neuroendocrine (NE) to a non-neuroendocrine (non-NE) phenotype. Read more
 Supervisors: Prof A Malliri, Dr K Simpson, Prof C Dive
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating WSB-1 as a prognostic marker and therapeutic target in urogenital cancers

The University of Manchester Faculty of Biology, Medicine and Health
Prostate cancer (PCa) is the commonest cancer diagnosed in men, with 5-year survival rates of 60% in those with advanced disease. Read more
 Supervisors: Dr IP Monteiro dos Santos Pires, Prof AC Choudhury
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The role of nuclear localisation of adhesion proteins in tumour growth and invasion

The University of Manchester Faculty of Biology, Medicine and Health
Overview. This project seeks to understand how tumour growth and invasion are controlled by the localisation of certain proteins in cancer cells. Read more
 Supervisors: Dr AB Byron, Dr K Finegan, Dr C Tournier
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Defining the molecular mechanisms of leukaemia chemotherapies

The University of Manchester Faculty of Biology, Medicine and Health
Chemotherapies are usually the backbone of cancer treatment for either curative or palliative patient care. Multiple therapies can be used for the same disease, with the choice of drug dependent on parameters such as the patient’s age and fitness. Read more
 Supervisors: Dr JK Knight, Dr K Batta, Dr D Wiseman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Characterisation of PA protease from Micrococcus luteus as a novel approach to the management of eczema

The University of Manchester Faculty of Biology, Medicine and Health
The chronic inflammatory skin disease, eczema, now affects approximately 15% of the paediatric population of the Western world and is growing in prevalence. Read more
 Supervisors: Prof CN O'neill, Prof A McBain
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Viral-surface interactions studied by vibrational sum-frequency spectroscopy

The University of Manchester Department of Materials
The recent COVID-19 pandemic, and in particular fomite transmission of the virus, led to a lot of interest in how viral particles attached to surfaces, their survival times on different materials and how they transferred to hosts. Read more
 Supervisors: Dr A Thomas, Dr R Lindsay
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Understanding and preventing the denaturation of proteins on surfaces in manufacture, storage and delivery of biotherapeutics

The University of Manchester Department of Materials
Protein and peptide therapeutics are pharmaceutical drug treatments derived from natural sources. They are applied to a range of diseases from diabetes to novel cancer therapies. Read more
 Supervisors: Dr A Thomas, Prof A Saiani
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Chaperones and the response to protein misfolding stress

The University of Manchester Faculty of Biology, Medicine and Health
Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more
 Supervisors: Prof C M Grant, Prof M Ashe
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the interaction of La related proteins with colliding ribosomes

The University of Manchester Faculty of Biology, Medicine and Health
Translation of mRNA into proteins is a critical cellular biological process for all life. This requires ribosomes to act with an array of translation factors to decode mRNA sequences. Read more
 Supervisors: Prof G D Pavitt, Dr A Roseman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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