The University of Manchester Biochemistry PhD Projects, Programmes & Scholarships

We have 21 The University of Manchester Biochemistry PhD Projects, Programmes & Scholarships

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(MRC DTP CASE) Development of new in vitro infection models to tackle antimicrobial resistance

The University of Manchester Faculty of Biology, Medicine and Health

Antimicrobial resistance (AMR) is one of the most serious global public health threats in this century. Read more

Supervisors: Dr S Gago, Dr M Bertuzzi, Dr J Bella

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) Prediction of substrate binding geometry and strength in promiscuous enzymes: computational chemistry applicable to the design of pharmaceuticals and agrochemicals

The University of Manchester Faculty of Biology, Medicine and Health

We are often taught about the power of enzymes to select particular substrates from the biological milieu and of their ability to perform highly selective reactions on those substrates. Read more

Supervisors: Dr A Leach, Dr S De Visser, Dr C Trujillo

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) Understanding how tumour associated macrophages control the tumour immune landscape in NF2-Schwannomatosis

The University of Manchester Faculty of Biology, Medicine and Health

Type 2 Neurofibromatosis (NF2), now referred to as NF2-Schwannomatosis (or NF2-SWN), is a rare autosomal dominant tumour pre-disposition syndrome characterised by growth of typically benign tumours throughout the nervous system. Read more

Supervisors: Prof D Brough, Dr K Couper

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) An Integrative Structural Biology Platform for Drug Discovery

The University of Manchester Faculty of Biology, Medicine and Health

Solute carriers (SLCs) are the second largest class of membrane-embedded proteins with over 400 members organised into 66 families. Read more

Supervisors: Dr A Politis, Dr CP Pliotas

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Targeting the mechanism of small GTPase splice variant RAC1B using ligand design

The University of Manchester Faculty of Biology, Medicine and Health

RAC1 is a small GTPase protein that functions as a key signalling node downstream of various microenvironmental signalling pathways. Read more

Supervisors: Dr RB Bryce, Dr S Butterworth, Dr T Jowitt, Dr A Ucar

Year round applications PhD Research Project Self-Funded PhD Students Only

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Assessing the contribution of the human microbiome to paediatric cancer and predisposition and chromosomal instability syndromes

The University of Manchester Faculty of Biology, Medicine and Health

A self-funded PhD studentship is available in the laboratories of Andrew McBain, Stefan Meyer and Chris Knight. The project aims to study the microbiome in paediatric cancer predisposition and chromosomal instability syndromes (CIS). Read more

Supervisors: Prof A McBain, Dr S Meyer, Dr C Knight

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding the role of spliceosome gene mutations in disease

The University of Manchester Faculty of Biology, Medicine and Health

The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made. Read more

Supervisors: Prof R O'Keefe, Prof B Newman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Unlocking the potential of plant cellulose for the production of new materials and chemicals

The University of Manchester Faculty of Biology, Medicine and Health

Plant biomass, in the form of plant cell walls are the only renewable resource sufficiently abundant to make a meaningful contribution to decreasing CO. Read more

Supervisors: Prof S Turner, Dr J Pittman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Driving phenotypic plasticity and metastasis in small cell lung cancer

The University of Manchester Faculty of Biology, Medicine and Health

Small cell lung cancer (SCLC) is an aggressive malignancy with poor prognosis. Underlying this aggressiveness is intra-tumoural heterogeneity driven by phenotypic plasticity wherein tumour cells transition from a neuroendocrine (NE) to a non-neuroendocrine (non-NE) phenotype. Read more

Supervisors: Prof A Malliri, Dr K Simpson, Prof C Dive

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating WSB-1 as a prognostic marker and therapeutic target in urogenital cancers

The University of Manchester Faculty of Biology, Medicine and Health

Prostate cancer (PCa) is the commonest cancer diagnosed in men, with 5-year survival rates of 60% in those with advanced disease. Read more

Supervisors: Dr IP Monteiro dos Santos Pires, Prof AC Choudhury

Year round applications PhD Research Project Self-Funded PhD Students Only

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The role of nuclear localisation of adhesion proteins in tumour growth and invasion

The University of Manchester Faculty of Biology, Medicine and Health

Overview. This project seeks to understand how tumour growth and invasion are controlled by the localisation of certain proteins in cancer cells. Read more

Supervisors: Dr AB Byron, Dr K Finegan, Dr C Tournier

Year round applications PhD Research Project Self-Funded PhD Students Only

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Defining the molecular mechanisms of leukaemia chemotherapies

The University of Manchester Faculty of Biology, Medicine and Health

Chemotherapies are usually the backbone of cancer treatment for either curative or palliative patient care. Multiple therapies can be used for the same disease, with the choice of drug dependent on parameters such as the patient’s age and fitness. Read more

Supervisors: Dr JK Knight, Dr K Batta, Dr D Wiseman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Characterisation of PA protease from Micrococcus luteus as a novel approach to the management of eczema

The University of Manchester Faculty of Biology, Medicine and Health

The chronic inflammatory skin disease, eczema, now affects approximately 15% of the paediatric population of the Western world and is growing in prevalence. Read more

Supervisors: Prof CN O'neill, Prof A McBain

Year round applications PhD Research Project Self-Funded PhD Students Only

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Chaperones and the response to protein misfolding stress

The University of Manchester Faculty of Biology, Medicine and Health

Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more

Supervisors: Prof C M Grant, Prof M Ashe

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the interaction of La related proteins with colliding ribosomes

The University of Manchester Faculty of Biology, Medicine and Health

Translation of mRNA into proteins is a critical cellular biological process for all life. This requires ribosomes to act with an array of translation factors to decode mRNA sequences. Read more

Supervisors: Prof G D Pavitt, Dr A Roseman

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 21 The University of Manchester Biochemistry PhD Projects, Programmes & Scholarships

The University of Manchester Biochemistry PhD Projects, Programmes & Scholarships

We have 21 The University of Manchester Biochemistry PhD Projects, Programmes & Scholarships

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