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Biochemistry (cells) PhD Projects, Programmes & Scholarships

We have 192 Biochemistry (cells) PhD Projects, Programmes & Scholarships

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Role of mechanical signals in a 3D human model of alveolar differentiation

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships
Alveolar epithelial type I (AT1) and type II (AT2) cells are essential for normal lung function following birth. Abnormal differentiation of AT1 and AT2 cells during development results in pulmonary pathology with associated neonatal mortality and long-term morbidity. Read more
 Supervisors: Dr S Loukogeorgakis, Dr F Michielin, Prof P De Coppi
 15 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Developing an ADAR-mediated RNA editing therapy for treatment of Duchenne Muscular Dystrophy

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships
Duchenne muscular dystrophy (DMD) is a severe X-linked genetic disorder affecting 1:5000 boys at birth (1). DMD is caused by mutations in Dystrophin gene, with around 10% of the cases caused by nonsense mutations (2,3). Read more
 Supervisors: Dr HZ Zhou, Dr J Meng, Prof F Muntoni
 15 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Determining metabolic reprogramming events in stem cells in response to inflammatory disease phenotype

University of Liverpool Institute of Life Course and Medical Sciences
Mesenchymal stem cells (MSCs) are responsible for the repair of damaged tissue following injury and disease as well as moderating innate and adaptive immune responses and regulation of self-tolerance and tissue homeostasis. Read more
 Supervisors: Dr R Oldershaw, Dr A Chadwick, Dr M Phelan, Dr BN Norman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Molecular mechanism of vimentin induced epithelial mesenchymal transition (EMT) and stemness in cancer cells

Queen Mary University of London Institute of Dentistry
Background. Most cancers are epithelial in origin and arise from a single progenitor cell, similar to an embryo, to become a clone of cells. Read more
 Supervisors: Prof A Waseem, Dr H Tummala, Dr F Flores-Borja
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Biological role of neuropeptides and their receptors

University of Reading School of Pharmacy
Cell signalling is critical to the co-ordination and functioning of all cells. Cell signalling allows cells to co-ordinate activities within the intracellular environment as well as ensuring cells know how to correctly respond to other cells and to an ever-changing extracellular environment as well. Read more
 Supervisor: Dr L Lander
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Targeting dormant cancer cells in myeloma

University of Sheffield School of Medicine and Population Health
Multiple myeloma is the second most common blood cancer and remains essentially incurable. Chemotherapy is effective at reducing tumour and extends survival, but it never fully eradicates disease, so patients face inevitable relapse. Read more
 Supervisors: Dr A Green, Prof S El-Khamisy
 31 May 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Studying protein homeostasis in healthy and malignant stem cells

University of York York Biomedical Research Institute
This PhD will focus on studying the protein biology of healthy and malignant stem cells of the blood system. Read more
 Supervisors: Dr W Grey, Prof D G Kent
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Pharmacological effects of cannabidiol (CBD) on mesenchymal stem cells in endometriosis

University of Reading School of Pharmacy
Endometriosis is a common long-term health condition that affects around 190 million women of reproductive age worldwide. It causes severe pain during periods, sex, going to the toilet, and sometimes just general pelvic discomfort, bloating, and tiredness. Read more
 Supervisors: Prof D Widera, Dr G Cottrell
 31 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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MSc by Research: Protein secretion landscapes in human immune cells

University of Dundee School of Life Sciences
Roughly one third of the human genome encodes secretory and membrane proteins. Following synthesis in the endoplasmic reticulum (ER), these proteins are captured into transport vesicles for delivery within the cell. Read more
 Supervisors: Dr L Miller, Dr A Howden
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Structural-guided PROTAC targeting of BMX to modulate apoptotic sensitivity in disease

University of Leicester Molecular and Cell Biology
What determines at the molecular level whether a cell lives or dies? Regulation of the cellular life–death switch is essential in healthy cells for normal foetal development and for the clearance of damaged cells. Read more
 Supervisors: Dr JF Fox, Dr JH Hodgkinson
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Ion channel signalling in cancer cells

University of York York Biomedical Research Institute
Our cells constantly sense and transport ions present in their environment. From embryonic development to epilepsy to heart disease to cancer, our cells’ ability to respond to changes in the ionic microenvironment is essential for healthy ageing. Read more
 Supervisor: Dr W Brackenbury
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Probing Death Decisions from Morphogen Gradient Fields

University of Liverpool Department of Molecular and Clinical Cancer Medicine
Morphogen gradient scaling is one of the hottest fields in developmental biology at the moment. Scaling is fundamental, explaining how the machinery that controls pattern formation in development (the morphogens) can adapt, so that organs of different sizes show morphological structures which are proportioned. Read more
 Supervisor: Dr MM Merino
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Creation of cell lines modelling complex karyotype in B cell lymphomas using CRISPR/Cas9

University of Liverpool Institute of Systems, Molecular and Integrative Biology
Chronic lymphocytic leukaemia (CLL) and diffuse large B cell lymphoma (DLBCL) make up more than half of all the newly diagnosed cases of non-Hodgkin’s lymphoma (NHL), the 6th most common cancer in the UK. Read more
 Supervisors: Dr J Slupsky, Dr N Kalakonda, Dr M Glenn
 1 May 2024  PhD Research Project  Self-Funded PhD Students Only
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Nanoparticle synthesis and application in magnetic field hyperthermia for cancer therapy

University of Bradford Faculty of Life Sciences
  Research Group: Chemistry and Biosciences
Magnetic field hyperthermia (MFH) is currently undergoing clinical trials for use in humans. The research to date has shown the effectiveness of the approach in cells and animal models and the initial results from human trials are promising. Read more
 Supervisors: Dr P Drake, Dr S Shnyder
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Targeting senescence to ameliorate ageing and treat cancer and other age-related diseases

University of Leicester Molecular and Cell Biology
Ageing is a biological process that affects all humans. Despite the scientific advances of the past decades, the mechanisms that lead to ageing are not fully understood. Read more
 Supervisor: Prof S Macip
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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