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We have 19 Biochemistry (lung) PhD Projects, Programmes & Scholarships

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Biochemistry (lung) PhD Projects, Programmes & Scholarships

We have 19 Biochemistry (lung) PhD Projects, Programmes & Scholarships

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Cancer biology: identification of new treatment options for EML4-ALK driven lung cancer through understanding mechanisms of cell division and migration.

University of Leicester Molecular and Cell Biology
Lung cancer is the largest cause of cancer-related deaths in the UK and worldwide. While little progress has been made in long-term survival rates, we now have a good understanding of the genetic drivers raising the prospect of earlier diagnosis and more effective treatments. Read more
 Supervisor: Prof A Fry
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Role of mechanical signals in a 3D human model of alveolar differentiation

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships
Alveolar epithelial type I (AT1) and type II (AT2) cells are essential for normal lung function following birth. Abnormal differentiation of AT1 and AT2 cells during development results in pulmonary pathology with associated neonatal mortality and long-term morbidity. Read more
 Supervisors: Dr S Loukogeorgakis, Dr F Michielin, Prof P De Coppi
 15 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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MSc by Research: Molecular characterisation of the factors driving lung fibrosis

University of Dundee School of Life Sciences
Idiopathic pulmonary fibrosis (IPF) is a progressive disease that results in an irreversible decline in lung function.  At present IPF is normally fatal and the median survival is between 2 and 5 years after diagnosis. Read more
 Supervisors: Prof S Arthur, Dr H McSorley
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Selective targeting of furin for the treatment of fibrotic lung disease.

Queen’s University Belfast School of Pharmacy
Furin, a proprotein convertase has been established as a therapeutic target across several disease areas to include chronic airways diseases and infectious disease, such as COVID-19 (reviewed in our recent publication, Douglas et al, 2023). Read more
 Supervisor: Prof L Martin
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Clinical: Gastroesophageal reflux in respiratory disease: pathogenic role and improved management

University of Leeds Faculty of Medicine and Health
Gastroesophageal reflux disease (GERD) is a condition in which stomach contents, such as food and acid pass into the gullet/oesophagus causing heartburn. GERD is very common in patients with lung disease, such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Read more
 Supervisors: Prof L Houghton, Dr D Peckham
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Driving phenotypic plasticity and metastasis in small cell lung cancer

The University of Manchester Faculty of Biology, Medicine and Health
Small cell lung cancer (SCLC) is an aggressive malignancy with poor prognosis. Underlying this aggressiveness is intra-tumoural heterogeneity driven by phenotypic plasticity wherein tumour cells transition from a neuroendocrine (NE) to a non-neuroendocrine (non-NE) phenotype. Read more
 Supervisors: Prof A Malliri, Dr K Simpson, Prof C Dive
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigation of novel protease-antiprotease imbalances associated with cystic fibrosis and the effect of CFTR correction.

Queen’s University Belfast School of Pharmacy
Cystic fibrosis (CF) is a progressive life-limiting airways disease that affects over 162,000 people worldwide. Read more
 Supervisor: Prof L Martin
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Evaluating the role of circulating proteins in cancer risk and progression using genetic and observational approaches

University of Bristol Bristol Medical School
Rationale. Circulating proteins play fundamental roles in biology and disease aetiology, including development of cancer, and are the direct targets of many drugs (1). Read more
 Supervisors: Prof R Martin, Dr JY Yarmolinsky, Dr P Haycock
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Live cell imaging of epithelial cancer cell proliferation for therapy

University of Leeds Faculty of Biological Sciences
The School of Molecular & Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more
 Supervisors: Prof A Divan, Dr S Ponnambalam, Dr M A Harrison
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Disrupted SUMO signalling in epithelial cancers, implications for genome stability and response to therapy.

University of Leeds Faculty of Biological Sciences
The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more
 Supervisor: Dr A Garvin
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The role of extracellular vesicles and intercellular signalling in inherited kidney cancer

Cardiff University Cardiff School of Medicine
This is a Self-Funded/Sponsored PhD opportunity. FUNDING REQUIRED. Full UK/EU or International Tuition Fees. UK Living Expenses. Bench Fees (£60,000 total). Read more
 Supervisor: Dr E Dunlop
 31 May 2024  PhD Research Project  Self-Funded PhD Students Only
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Targeting the mechanism of small GTPase splice variant RAC1B using ligand design

The University of Manchester Faculty of Biology, Medicine and Health
RAC1 is a small GTPase protein that functions as a key signalling node downstream of various microenvironmental signalling pathways. Read more
 Supervisors: Dr RB Bryce, Dr S Butterworth, Dr T Jowitt, Dr A Ucar
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Preclinical testing of collagen synthesis inhibitors for fibrotic disease

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Fibrotic disease is characterised by an excessive accumulation of collagen within tissues, which then impedes tissue function. Organ fibrosis specifically kidney fibrosis, liver fibrosis, cardiac fibrosis and lung fibrosis have limited treatment options, pose a huge clinical burden and are life-limiting diseases. Read more
 Supervisor: Dr EG Laird
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the impact of galectin-ligand interaction on cancer cell resistance to chemotherapeutic treatment

University of Liverpool Institute of Life Course and Medical Sciences
Galectins are multifunctional carbohydrate-binding proteins that are expressed by many types of human cells. Changes of galectin expression commonly occur in cancer (e.g. Read more
 Supervisor: Prof LG Yu
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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(University of Manchester - University of Tokyo Dual Award) Diversifying Antitumor Drugs through the Integration of Synthetic Biology and Chemo-enzymatic Approaches

The University of Manchester Department of Chemistry
Ecteinascidin 743 (ET-743, Trabectedin) is a marine-derived natural organic compound approved for the treatment of soft tissue sarcomas. Read more
 Supervisors: Prof E Takano, Prof H Oguri
 29 April 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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