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We have 34 Biochemistry (transcription) PhD Projects, Programmes & Scholarships

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Biochemistry (transcription) PhD Projects, Programmes & Scholarships

We have 34 Biochemistry (transcription) PhD Projects, Programmes & Scholarships

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Chromatin regulation of oncogenic transcription and replication stress: mechanism and functional implications in acute myeloid leukemia

University of Liverpool Institute of Systems, Molecular and Integrative Biology
This project focuses on the molecular mechanisms promoting acute myeloid leukaemia (AML), a disease of great unmet need. AML is an aggressive blood and bone marrow cancer characterized by abnormal proliferation and differentiation of myeloid cells. Read more
 Supervisors: Dr M Papamichos Chronakis, Prof D MacEwan, Dr A Kanhere
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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ROLE OF FOXO1 TRANSCRIPTION FACTOR IN B-CELL MALIGNANCIES

Masaryk University Faculty of Medicine
The project is focused on FoxO1 transcription factor and its role in the pathophysiology of chronic lymphocytic leukemia (CLL). Although the therapy of CLL has made several remarkable improvements, the disease still remains incurable. Read more
 Supervisor: Assoc Prof Marek Mraz
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Characterization of cyclin-dependent kinase 12 (CDK12) substrates and their roles in regulation of transcription and tumorigenesis

Masaryk University Faculty of Medicine
Doctoral study program. Life Sciences. Research area. RNA/nucleic acids research in health, cancer biology. Cdk12 is transcriptional cyclin-dependent kinase (Cdk) found mutated in various cancers. Read more
 Supervisor: Dr D Blažek
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Understanding control of genome folding by cohesin

University of Leicester Molecular and Cell Biology
Our basic goal is to understand how chromatin structure influences gene regulation. Chromatin is generally repressive in nature but its structure is manipulated by cells in a regulated way to determine which genes are potentially transcriptionally active and which genes remain repressed in a given cell type. Read more
 Supervisors: Prof D Panne, Dr T Schalch
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Structural insights into genome control by cohesin

University of Leicester Molecular and Cell Biology
Our basic goal is to understand how chromatin structure influences gene regulation. Chromatin is generally repressive in nature but its structure is manipulated by cells in a regulated way to determine which genes are potentially transcriptionally active and which genes remain repressed in a given cell type. Read more
 Supervisor: Prof D Panne
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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PhD studentship - Defining the mechanisms underpinning HIF-1 and HIF-2 dependent transcriptional specificity in hypoxia.

Newcastle University Biosciences Institute
Award summary. 100% of home tuition fees paid and annual living expenses of £18,622. Overview. The cellular response to low oxygen levels (hypoxia), is crucial for cell survival and identity. Read more
 Supervisor: Dr B Ortmann
 14 June 2024  PhD Research Project  Funded PhD Project (European/UK Students Only)
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Molecular mechanism of vimentin induced epithelial mesenchymal transition (EMT) and stemness in cancer cells

Queen Mary University of London Institute of Dentistry
Background. Most cancers are epithelial in origin and arise from a single progenitor cell, similar to an embryo, to become a clone of cells. Read more
 Supervisors: Prof A Waseem, Dr H Tummala, Dr F Flores-Borja
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The Survivin Interactome in Health and Disease

University of Nottingham School of Life Sciences
Survivin is a small protein that is essential for life but that also contributes to disease, most notably cancer, in which its abnormal overexpression is linked to therapeutic resistance and metastasis. Read more
 Supervisor: Dr S Wheatley
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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BARIToNE: Improving barley climate resilience using a candidate gene approach (Project code 24H)

The James Hutton Institute PhD Opportunities
Supervisors. Lead supervisor - Dr Martin Balcerowicz, University of Dundee. Second supervisor - Dr Craig Simpson, James Hutton Institute. Read more
 Supervisors: Dr M Balcerowicz, Dr C Simpson, Ms G MacDonald
 31 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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BARIToNE: Improving barley climate resilience using a candidate gene approach (Project code 24H)

University of Dundee School of Life Sciences
Supervisors. Lead supervisor - Dr Martin Balcerowicz, University of Dundee. Second supervisor - Dr Craig Simpson, James Hutton Institute. Read more
 Supervisors: Dr M Balcerowicz, Dr C Simpson, Ms G MacDonald
 31 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression and tumorigenesis

Masaryk University Faculty of Medicine
Doctoral study program. Life Sciences. Research area. RNA/nucleic acids research in health, cancer biology. CDK11 is ubiquitously expressed in all tissues and the CDK11 null mouse is lethal at an early stage of development indicating an important role for Cdk11 in the adult as well as during development. Read more
 Supervisor: Dr D Blažek
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Retrotransposons in immunity

UNSW Sydney School of Biotechnology and Biomolecular Sciences
Only about 1-2% of our genome is made up of protein coding genes, the rest is non-coding and at least half of that is made up of repetitive DNA sequences known as transposable elements (TEs). Read more
 Supervisor: Prof C King
 Year round applications  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Mechanisms controlling gene expression in hypoxia and inflammation

University of Liverpool Institute of Systems, Molecular and Integrative Biology
Oxygen is one of the most important molecules for life. Every member of the animal kingdom depends on oxygen to help metabolize its food and drive many critical processes in metabolism. Read more
 Supervisor: Prof S Rocha
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Circadian mechanisms in psoriasis: therapeutic opportunities

The University of Manchester Faculty of Biology, Medicine and Health
Hallmark features of psoriasis symptoms vary through time, suggesting an important role for circadian circuits in driving disease expression, and offering the potential of chronotherapy. Read more
 Supervisors: Dr H Young, Dr I Iqbal, Prof D Ray
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Self-funded MSc R- The mechanisms driving heterogeneity and stemness during cellular transformation.

University of Bristol School of Cellular and Molecular Medicine
The mechanisms driving heterogeneity and stemness during cellular transformation. Read more
 Supervisor: Dr A Essafi
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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