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We have 16 Biochemistry (x-ray crystallography) PhD Projects, Programmes & Scholarships

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Biochemistry (x-ray crystallography) PhD Projects, Programmes & Scholarships

We have 16 Biochemistry (x-ray crystallography) PhD Projects, Programmes & Scholarships

Structural-guided PROTAC targeting of BMX to modulate apoptotic sensitivity in disease

What determines at the molecular level whether a cell lives or dies? Regulation of the cellular life–death switch is essential in healthy cells for normal foetal development and for the clearance of damaged cells. Read more

Funded PhD studentship in XFEL Science at Imperial College London

A fully funded 4-year PhD position is available in the group of Professor Jasper van Thor at Imperial College London. The PhD is supported by the STFC UK Hub for the physical sciences on XFELs (HPSX) and Imperial College. Read more

Molecular level understanding of Mycobacterium tuberculosis

Mycobacterium tuberculosis has evolved to survive and replicate inside macrophages. The project will investigate the molecular mechanisms underpinning adaptation to this specialised intracellular niche. Read more

Chemically Modified Therapeutic Nucleic Acids for Neurological Diseases

Therapeutic oligonucleotides are unique in targeting mRNA particularly those that cannot be addressed by conventional small molecule drugs or therapeutic antibodies, their potential is growing fast. Read more
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Structural basis of two-component system signaling

Background: . As bacteria explore new habitats, go to war with competitors or collaborate against common enemies, they rely heavily on intra- and interspecies communication and precise molecular scouting of their environment. Read more

Structural and functional characterisation of MALT1 ubiquitination to aid in the development of novel anti-cancer therapies

Nuclear factor-kappa B (NF-kB) is a family of transcription factors that play a crucial role in regulating various cellular processes; primarily related to immune responses, inflammation, and cell survival. Read more

The identification of allosteric inhibitors of high value therapeutic targets

This study will develop a novel approach to identify allosteric inhibitor sites on a wide variety of high-value therapeutic targets, including protein kinases, protein phosphatases and small G-proteins. Read more

Structural investigation of oncogenic splicing factors

More than 90% of human genes can and do express multiple proteins. This is achieved by a process called alternative RNA splicing, which is an essential step in gene expression in mammals. Read more

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