Biochemistry PhD Research Projects PhD Projects, Programmes & Scholarships in Loughborough

We have 22 Biochemistry PhD Research Projects PhD Projects, Programmes & Scholarships in Loughborough

Unlocking the Secrets of Genome Regulation through cryo-EM

University of Leicester Molecular and Cell Biology

Are you an ambitious spirit, ready to make breakthrough discoveries at the frontier of epigenetics? Dive deep into the fascinating world of eukaryotic genomes with us! . Read more

Supervisors: Dr T Schalch, Dr AC Chaplin

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Join Our Quest to Unravel the Secrets of Eukaryotic Genomes!

University of Leicester Molecular and Cell Biology

We're on the lookout for passionate PhD students who are eager to delve deep into the mysteries of our DNA. Our quest? To understand the subtle changes that determine how our genes function, both in sickness and in health. Read more

Supervisor: Dr T Schalch

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding control of genome folding by cohesin

University of Leicester Molecular and Cell Biology

Our basic goal is to understand how chromatin structure influences gene regulation. Chromatin is generally repressive in nature but its structure is manipulated by cells in a regulated way to determine which genes are potentially transcriptionally active and which genes remain repressed in a given cell type. Read more

Supervisors: Prof D Panne, Dr T Schalch

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Structural investigation of oncogenic splicing factors

University of Leicester Molecular and Cell Biology

More than 90% of human genes can and do express multiple proteins. This is achieved by a process called alternative RNA splicing, which is an essential step in gene expression in mammals. Read more

Supervisors: Dr C Dominguez, Prof I Eperon, Prof A Hudson

Year round applications PhD Research Project Self-Funded PhD Students Only

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Obtaining an integrated understanding of oncogenic RAS signalling

University of Leicester Molecular and Cell Biology

The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. The physiological importance of RAS signalling is evident as about 25% of all human cancers harbour mutations in ras genes, where kras is most frequently mutated (about 18%) (COSMIC, v94). Read more

Supervisor: Dr K Tanaka

Year round applications PhD Research Project Self-Funded PhD Students Only

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How do RNA-binding proteins control splice site selection? A multi-disciplinary approach

University of Leicester Molecular and Cell Biology

Almost every protein-coding gene in vertebrates can and does express multiple proteins. This is achieved primarily by RNA splicing, which is an essential step in gene expression in mammals and generates incredible diversity. Read more

Supervisors: Prof I Eperon, Prof A Hudson, Dr C Dominguez

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding gene regulation by HDAC1 complexes in development and cancer

University of Leicester Molecular and Cell Biology

Packaging DNA into nucleosomes helps protect the long fragile genomes of eukaryotic species. However, in doing so it becomes an ever-present physical barrier to the machinery required for its replication, repair and transcription. Read more

Supervisor: Prof S Cowley

Year round applications PhD Research Project Self-Funded PhD Students Only

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Chemical energy conversion in biology studied using advanced spectroscopic and structural tools

University of Leicester Department of Chemistry

Redox properties of metal-containing active sites are critically important to many biocatalytic processes. one third of all proteins contain a redox-active metal, and ca 22% of submissions to the Protein Data Bank contain a transition metal. Read more

Supervisors: Dr PA Ash, Dr H Kwon

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Natural products in bacterial physiology and chemical interaction

University of Leicester Department of Genetics and Genome Biology

Microbial natural products have diverse chemical structures and bioactivities, which range from cell-cell signalling, nutrient acquisition, antifungal and antibacterial activity to stress resistance (1). Read more

Supervisors: Dr C Jenul, Prof D Jones

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Obtaining insights into how a signalling hub protein Ras activates multiple effectors

University of Leicester Molecular and Cell Biology

The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. They are highly conserved from yeast to humans, highlighting their fundamental biological roles. Read more

Supervisors: Dr K Tanaka , Dr R Mahen

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Molecular level understanding of Mycobacterium tuberculosis

University of Leicester Department of Respiratory Sciences

Mycobacterium tuberculosis has evolved to survive and replicate inside macrophages. The project will investigate the molecular mechanisms underpinning adaptation to this specialised intracellular niche. Read more

Supervisors: Dr H O'Hare, Dr N Garton

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Understanding the roles of triacylglycerol in modulating mycobacterial growth and biophysical properties

University of Leicester Department of Respiratory Sciences

Mycobacteria contain more lipid than any other bacteria. In addition to a characteristically lipid-rich cell envelope, mycobacteria can accumulate triacylglycerol (TAG) as cytoplasmic lipid bodies (LBs). Read more

Supervisors: Dr N Garton , Dr G Mukamolova

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Structural-guided PROTAC targeting of BMX to modulate apoptotic sensitivity in disease

University of Leicester Molecular and Cell Biology

What determines at the molecular level whether a cell lives or dies? Regulation of the cellular life–death switch is essential in healthy cells for normal foetal development and for the clearance of damaged cells. Read more

Supervisors: Dr JF Fox, Dr JH Hodgkinson

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Molecular Glues as Novel Tools for Tackling Big Challenges in Human Health

University of Leicester Department of Chemistry

Background. The need for new medicines is greater than ever because of an ageing population and the complex clinical challenges brought about by drug resistance and/or side effects. Read more

Supervisors: Dr RD Doveston, Prof S Macip

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Chemical energy conversion in biology studied using advanced spectroscopic and structural tools

University of Leicester Department of Chemistry

Graduate Teaching Assistantship. This is a Graduate Training Assistantship (GTA), which means that you will be required to do some teaching, particularly lab demonstrating, as part of your training. Read more

Supervisor: Dr P Ash

22 April 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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We have 22 Biochemistry PhD Research Projects PhD Projects, Programmes & Scholarships in Loughborough

Biochemistry PhD Research Projects PhD Projects, Programmes & Scholarships in Loughborough

We have 22 Biochemistry PhD Research Projects PhD Projects, Programmes & Scholarships in Loughborough

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