The University of Manchester Bioinformatics PhD Research Projects PhD Projects, Programmes & Scholarships

We have 14 The University of Manchester Bioinformatics PhD Research Projects PhD Projects, Programmes & Scholarships

(MRC DTP CASE) Determination of the role of viruses in the microbiome of biofilms formed in the ear of patients with otitis media

The University of Manchester Faculty of Biology, Medicine and Health

Otitis media (OM) is a very common infection of the middle ear characterised by redness, swelling and build-up of fluid behind the eardrum. Read more

Supervisors: Prof P Vallely, Prof P Klapper, Prof S Lovell, Mrs JN Nichani

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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(MRC DTP CASE) Multiomic evaluation of differential drug response in metastatic breast cancers

The University of Manchester Faculty of Biology, Medicine and Health

Breast cancers are the most common cancers in women. Estrogen Receptor (ER) plays a major role in breast cancer growth. To stop the cancer from growing further, clinically successful ER-targeting therapies like Fulvestrant, etc were developed. Read more

Supervisors: Dr S Nagarajan, Dr HH Harrison, Prof R Clarke, Dr I Iqbal

13 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Understanding how to target the T cell compartment within related brain tumours

The University of Manchester Faculty of Biology, Medicine and Health

T cell-based immunotherapy has revolutionised the treatment of many different types of cancer. However, to date, these treatments have not been successful or widely used for the treatment of brain tumours. Read more

Supervisors: Dr K Couper, Prof D Brough, Dr OP Pathmanaban

Year round applications PhD Research Project Self-Funded PhD Students Only

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VariantVisualiser: Ensuring precise diagnoses of genetic disorders through the development of intuitive software that facilitates the integration and visualisation of complex informatics with biological and clinical data

The University of Manchester Faculty of Biology, Medicine and Health

Rare diseases affect. This proposal builds on substantial efforts of a Human Genome Organization committee which has proposed a unified professional-standard for representing genomic data which, when finalised, will be adopted world-wide. Read more

Supervisors: Dr S Pettifer, Dr PF Freeman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Eco-evolutionary dynamics of environmental microbiomes

The University of Manchester Faculty of Biology, Medicine and Health

Include details on the project, outlining the objectives, methods and potential outcomes. Include details of training/techniques to be provided. Read more

Supervisors: Prof M Brockhurst, Dr S Nixon, Dr K Coyte

15 June 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Identifying variants impacting splicing of 5’ and 3’ UTRs and underpinning inherited retinal disease

The University of Manchester Faculty of Biology, Medicine and Health

Genomic variation that impacts splicing is well established as a cause of genomic disorders, but is almost exclusively limited to protein-coding exons and introns intersecting protein-coding exons. Read more

Supervisors: Dr J Ellingford, Prof R O'Keefe

15 June 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Determining the biological basis of observed clinical outcomes in juvenile idiopathic arthritis using genetics and multiomics

The University of Manchester Faculty of Biology, Medicine and Health

Juvenile idiopathic arthritis (JIA) is a chronic inflammatory arthritis affecting children and young people with an age of disease onset less than 16 years of age. Read more

Supervisors: Dr J Bowes, Dr J Humphreys

Year round applications PhD Research Project Self-Funded PhD Students Only

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Discerning the role of metabolic proteins in nucleus

The University of Manchester Faculty of Biology, Medicine and Health

Pancreatic Ductal Adenocarcinoma (PDAC), which develops from cells lining pancreas ducts, represents 95% of all pancreatic cancer cases. Read more

Supervisor: Dr A Latif

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identification and characterization of disease-specific subsets of antigen-presenting cells (APC) in inflammatory arthritis

The University of Manchester Faculty of Biology, Medicine and Health

Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies. Read more

Supervisors: Dr S Viatte, Prof A Barton, Mr P Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Development and validation of a radiosensitivity gene expression signature in prostate cancer

The University of Manchester Faculty of Biology, Medicine and Health

Prostate cancer (PCa) is diagnosed in 1.4 million men globally each year and causes 375,000 deaths, making PCa the second most common cancer and fifth most common cause of death from cancer in men[1]. Read more

Supervisors: Prof A Choudhury, Dr MR Reardon, Dr TS Smith

Year round applications PhD Research Project Self-Funded PhD Students Only

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Modelling the ecology and evolution of microbial communities

The University of Manchester Faculty of Biology, Medicine and Health

From the human gut to deep-sea sediments, microbial communities – or microbiomes – colonize virtually every habitat on earth. These microbiomes are central to ecosystem functioning and to host health, and therefore it is essential that we understand how and why they change over time. Read more

Supervisors: Dr K Coyte, Dr C Knight

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the genetic basis of immunological overlap between inflammatory diseases

The University of Manchester Faculty of Biology, Medicine and Health

Genetic studies have identified numerous variants within the human genome associated with susceptibility to common complex inflammatory diseases, such as rheumatoid arthritis (RA) and ulcerative colitis (UC). Read more

Supervisors: Mr P Martin, Prof S Eyre, Prof A Morris

Year round applications PhD Research Project Self-Funded PhD Students Only

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A deep-learning approach to genomic regulation of tissue-specific alternative splicing

The University of Manchester Faculty of Biology, Medicine and Health

Each human gene is a blueprint for multiple distinct RNA transcripts that can be produced in differing quantities based on the localisation of the transcribing… Read more

Supervisors: Dr JE Eales, Prof T Papamarkou

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identifying critical pathways regulating autoimmunity in immuno-oncology and arthritis patients. Short title: IPADS (Immune PAthways for Drug Side-effects)

The University of Manchester Faculty of Biology, Medicine and Health

Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies (inc. Read more

Supervisors: Dr S Viatte, Prof A Barton, Mr P Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 14 The University of Manchester Bioinformatics PhD Research Projects PhD Projects, Programmes & Scholarships

The University of Manchester Bioinformatics PhD Research Projects PhD Projects, Programmes & Scholarships

We have 14 The University of Manchester Bioinformatics PhD Research Projects PhD Projects, Programmes & Scholarships

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