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We have 74 Bioinformatics (clinical) PhD Projects, Programmes & Scholarships

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Bioinformatics (clinical) PhD Projects, Programmes & Scholarships

We have 74 Bioinformatics (clinical) PhD Projects, Programmes & Scholarships

Clinical Gastroenterology: Investigation of Fidaxomicin Resistance Mechanisms in Clostridium difficile

Clostridium difficile is a leading pathogen in healthcare-associated diarrheal infections. C. difficile has a plastic genome with multiple mobile genetic elements and recognized capacity to acquire genes involved in resistance and virulence. Read more

NIHR Leeds BRC: Pre-clinical evaluation of novel regenerative medicine strategies for knee osteoarthritis

Historically, articular cartilage was considered incapable of spontaneous repair.  However, biomechanical correction in osteoarthritis (OA) using high tibial osteotomy or joint distraction demonstrated the remarkable joint to regeneration by “merely” correcting joint alignment. Read more

NIHR Leeds BRC: Multimodal predictive modelling of outcome in patients with gastrointestinal cancer

Worldwide, cancer of the upper (oesophagus, stomach) and lower gastrointestinal (colon and rectum) tract is newly diagnosed in 3.6 million patients every year and 2.2 million patients die from this disease every year. Read more

Clinical Gastroenterology: The regulation of GDH expression in Clostridioides difficile

Clostridioides difficile infection (CDI), the most common cause of infective antibiotic-associated diarrhea in the western world, is diagnosed by a combination of tests that firstly detect the organism, then the toxins that it produces (Planche 2013). Read more

NIHR GOSH BRC Translational Research (Non-Clinical) PhD Studentships

The NIHR Great Ormond Street Hospital Biomedical Research Centre (NIHR GOSH BRC) PhD Studentship Programme aims to fund five highly motivated non-clinical PhDs students to support the training and development of the next generation of translational researchers. Read more

From bench to pre-clinical evaluation: a novel nucleic acid vaccine targeting tumour-associated antigens

Cancer and the long-term toxicities sustained from treatment remain a public health issue for adult and paediatric patients. The spread of tumour cells is believed to account for up to 90% of cancer-related morbidities. Read more

An optimal framework for disease risk prediction and stratification for multi-ethnic populations (ref: SF22/HLS/APP/Chimusa)

The exceptional polygenicity of human traits makes unravelling mechanisms from disease risk prediction models daunting. The development of polygenic risk scores (PRS) methods, their evaluation and clinical utility have been explored almost in European ancestry Genome-Wide Association Studies (GWAS) data sets. Read more

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