Bioinformatics (manchester) PhD Projects, Programmes & Scholarships

NMR approaches for understanding mass transfer in microbial biofilms and sessile microbial communities

The University of Manchester Department of Chemistry

Biofilms are structured sessile communities of microorganisms with relevance in many areas of life. They are almost omnipresent in aquatic and terrestrial ecosystems. Read more

Supervisors: Prof M Nilsson, Prof A McBain

Year round applications PhD Research Project Self-Funded PhD Students Only

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New Methods for modelling cofactor-dependent enzyme structure and function

The University of Manchester Department of Chemistry

Enzymes are Nature’s catalysts and many used cofactors and/or coenzymes to catalyse their reactions. While AI and homology methods now often allow the useful prediction of protein structure from amino acid sequence, this can be more challenging when the protein/enzyme contain cofactors. Read more

Supervisor: Prof S Hay

27 October 2024 PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Identifying variants impacting splicing of 5’ and 3’ UTRs and underpinning inherited retinal disease

The University of Manchester Faculty of Biology, Medicine and Health

Genomic variation that impacts splicing is well established as a cause of genomic disorders, but is almost exclusively limited to protein-coding exons and introns intersecting protein-coding exons. Read more

Supervisors: Dr J Ellingford, Prof R O'Keefe

15 June 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Determining the biological basis of observed clinical outcomes in juvenile idiopathic arthritis using genetics and multiomics

The University of Manchester Faculty of Biology, Medicine and Health

Juvenile idiopathic arthritis (JIA) is a chronic inflammatory arthritis affecting children and young people with an age of disease onset less than 16 years of age. Read more

Supervisors: Dr J Bowes, Dr J Humphreys

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identifying critical pathways regulating autoimmunity in immuno-oncology and arthritis patients. Short title: IPADS (Immune PAthways for Drug Side-effects)

The University of Manchester Faculty of Biology, Medicine and Health

Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies (inc. Read more

Supervisors: Dr S Viatte, Prof A Barton, Mr P Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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New enzymatic routes for the synthesis of peptide therapeutics

The University of Manchester Department of Chemistry

Peptides are essential in life and are widely used as therapeutic agents, vaccines, biomaterials and in other important applications. Read more

Supervisor: Prof J Micklefield

19 April 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Discerning the role of metabolic proteins in nucleus

The University of Manchester Faculty of Biology, Medicine and Health

Pancreatic Ductal Adenocarcinoma (PDAC), which develops from cells lining pancreas ducts, represents 95% of all pancreatic cancer cases. Read more

Supervisor: Dr A Latif

Year round applications PhD Research Project Self-Funded PhD Students Only

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Eco-evolutionary dynamics of environmental microbiomes

The University of Manchester Faculty of Biology, Medicine and Health

Include details on the project, outlining the objectives, methods and potential outcomes. Include details of training/techniques to be provided. Read more

Supervisors: Prof M Brockhurst, Dr S Nixon, Dr K Coyte

15 June 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Modelling the ecology and evolution of microbial communities

The University of Manchester Faculty of Biology, Medicine and Health

From the human gut to deep-sea sediments, microbial communities – or microbiomes – colonize virtually every habitat on earth. These microbiomes are central to ecosystem functioning and to host health, and therefore it is essential that we understand how and why they change over time. Read more

Supervisors: Dr K Coyte, Dr C Knight

Year round applications PhD Research Project Self-Funded PhD Students Only

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A deep-learning approach to genomic regulation of tissue-specific alternative splicing

The University of Manchester Faculty of Biology, Medicine and Health

Each human gene is a blueprint for multiple distinct RNA transcripts that can be produced in differing quantities based on the localisation of the transcribing… Read more

Supervisors: Dr JE Eales, Prof T Papamarkou

Year round applications PhD Research Project Self-Funded PhD Students Only

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Characterising human sebum using NMR approaches

The University of Manchester Department of Chemistry

We have recently shown that skin secretions in particular sebum, has a critical diagnostic role in other diseases unrelated directly to the skin. Read more

Supervisors: Dr D K Trivedi, Prof M Nilsson, Prof GA Morris

Year round applications PhD Research Project Self-Funded PhD Students Only

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Interpretable machine learning to identify biomarkers from multi-omics data of human cancer

The University of Manchester Department of Computer Science

This project aims to address the critical field of cancer research, a leading cause of death globally. Read more

Supervisor: Dr H Zhou

Year round applications PhD Research Project Competition Funded PhD Project (Students Worldwide)

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Understanding how to target the T cell compartment within related brain tumours

The University of Manchester Faculty of Biology, Medicine and Health

T cell-based immunotherapy has revolutionised the treatment of many different types of cancer. However, to date, these treatments have not been successful or widely used for the treatment of brain tumours. Read more

Supervisors: Dr K Couper, Prof D Brough, Dr OP Pathmanaban

Year round applications PhD Research Project Self-Funded PhD Students Only

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VariantVisualiser: Ensuring precise diagnoses of genetic disorders through the development of intuitive software that facilitates the integration and visualisation of complex informatics with biological and clinical data

The University of Manchester Faculty of Biology, Medicine and Health

Rare diseases affect. This proposal builds on substantial efforts of a Human Genome Organization committee which has proposed a unified professional-standard for representing genomic data which, when finalised, will be adopted world-wide. Read more

Supervisors: Dr S Pettifer, Dr PF Freeman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identification and characterization of disease-specific subsets of antigen-presenting cells (APC) in inflammatory arthritis

The University of Manchester Faculty of Biology, Medicine and Health

Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies. Read more

Supervisors: Dr S Viatte, Prof A Barton, Mr P Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 23 Bioinformatics (manchester) PhD Projects, Programmes & Scholarships

Bioinformatics (manchester) PhD Projects, Programmes & Scholarships

We have 23 Bioinformatics (manchester) PhD Projects, Programmes & Scholarships

NMR approaches for understanding mass transfer in microbial biofilms and sessile microbial communities

New Methods for modelling cofactor-dependent enzyme structure and function

Identifying variants impacting splicing of 5’ and 3’ UTRs and underpinning inherited retinal disease

Determining the biological basis of observed clinical outcomes in juvenile idiopathic arthritis using genetics and multiomics

Identifying critical pathways regulating autoimmunity in immuno-oncology and arthritis patients. Short title: IPADS (Immune PAthways for Drug Side-effects)

New enzymatic routes for the synthesis of peptide therapeutics

Discerning the role of metabolic proteins in nucleus

Eco-evolutionary dynamics of environmental microbiomes

Modelling the ecology and evolution of microbial communities

A deep-learning approach to genomic regulation of tissue-specific alternative splicing

Characterising human sebum using NMR approaches

Interpretable machine learning to identify biomarkers from multi-omics data of human cancer

Understanding how to target the T cell compartment within related brain tumours

VariantVisualiser: Ensuring precise diagnoses of genetic disorders through the development of intuitive software that facilitates the integration and visualisation of complex informatics with biological and clinical data

Identification and characterization of disease-specific subsets of antigen-presenting cells (APC) in inflammatory arthritis

We have 23 Bioinformatics (manchester) PhD Projects, Programmes & Scholarships

Bioinformatics (manchester) PhD Projects, Programmes & Scholarships

We have 23 Bioinformatics (manchester) PhD Projects, Programmes & Scholarships

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