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We have 17 Molecular Biology PhD Research Projects PhD Projects, Programmes & Scholarships in Bristol

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Molecular Biology PhD Research Projects PhD Projects, Programmes & Scholarships in Bristol

We have 17 Molecular Biology PhD Research Projects PhD Projects, Programmes & Scholarships in Bristol

University of Bristol

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4-year PhD Studentship: Combatting bacterial zoonoses through multi-disciplinary studies of virulence factors

University of Bristol Bristol Veterinary School
Vector-borne diseases, including bacterial zoonoses, pose a significant threat to human and animal health and to livestock industries, particularly in low and middle-income countries. Read more
 Supervisor: Dr T Cogan
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Self-funded PhD- Re-engineering Golgi dynamics in plants – investigating the role of myosin receptors

University of Bristol School of Biological Sciences
The growing global population requires the development of novel strategies to sustainably increase food production. Organelle movement is dynamic and linked to changes in cell size, plant biomass and in response to factors which affect food production such as pathogens (Perico and Sparkes, New Phytol. Read more
 Supervisor: Dr I Sparkes
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Self-funded MSc R- Re-engineering Golgi dynamics in plants – investigating the role of myosin receptors

University of Bristol School of Biological Sciences
The growing global population requires the development of novel strategies to sustainably increase food production. Organelle movement is dynamic and linked to changes in cell size, plant biomass and in response to factors which affect food production such as pathogens (Perico and Sparkes, New Phytol. Read more
 Supervisor: Dr I Sparkes
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the role of dietary fructose in the development of early-onset colorectal cancer

University of Bristol Bristol Medical School
Project Background. This project will investigate the role of fructose in the development of early-onset colorectal cancer (EOCRC) in adults <50 years. Read more
 Supervisors: Dr E Vincent, Dr A Chambers, Dr R Richmond, Dr NM Murphy
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Self-funded PhD- Understanding the molecular mechanism of a bacterial genome defence system and its synergy with CRISPR-Cas

University of Bristol School of Biochemistry
Prokaryotes have evolved over billions of years alongside their viruses, the bacteriophages, or “phages”. To prevent viral infection, prokaryotes have evolved rudimentary immune mechanisms, the most widespread and well-studied of which are the Restriction-Modification and the CRISPR-Cas enzymes. Read more
 Supervisor: Prof M D Szczelkun
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Evaluating the role of circulating proteins in cancer risk and progression using genetic and observational approaches

University of Bristol Bristol Medical School
Rationale. Circulating proteins play fundamental roles in biology and disease aetiology, including development of cancer, and are the direct targets of many drugs (1). Read more
 Supervisors: Prof R Martin, Dr JY Yarmolinsky, Dr P Haycock
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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The use of life course epidemiology to support the experimental characterisation of genetic variation

University of Bristol Bristol Medical School
Project Background. There has been a rapid expansion in the generation of genetic sequence data over the last decade. Understanding the potential relevance of genetic mutations to human health remains challenging. Read more
 Supervisors: Prof N Timpson, Dr L Corbin, Dr BL Lam
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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MScR: Involvement of astrocytes in neurological manifestations of Long COVID syndrome

University of Bristol School of Physiology, Pharmacology & Neuroscience
A significant fraction of patients affected by Long COVID, long-term consequences following acute SARS-CoV-2 infection, suffer from mental fatigue and cognitive deficits (1-3). Read more
 Supervisor: Prof A Teschemacher
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Self-funded PhD- Exploring the Mechanisms of Bacterial Pathogen Entry and Colonization in Plants through Wounds

University of Bristol School of Biological Sciences
How bacterial pathogens enter and colonise plant via wounds?. Wounding of plants by hard wind, hail, heavy rain, sand storms, and frost is common in nature. Read more
 Supervisors: Dr P Buscaill, Dr A Bailey
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Self-funded PhD- Interplay between environmental toxins and cancer predisposition

University of Bristol School of Cellular and Molecular Medicine
Cancer arises in part from intrinsic molecular and cellular alterations. For instance, loss of major DNA damage response genes such as BRCA1/2 has long been known to predispose individuals to multiple cancer types. Read more
 Supervisor: Dr S Koh
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MScR - Computational modelling to investigate the role of membrane microdomains in cell signalling

University of Bristol School of Physiology, Pharmacology & Neuroscience
The dynamic organization of the plasma membrane into specialized cholesterol-rich microdomains plays a crucial role in cellular signalling and the regulation of various biological processes. Read more
 Supervisor: Dr RC Corey
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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MScR: Endosomal Trafficking Dysfunction in Astrocytes: A Roadmap to Alzheimer’s disease?

University of Bristol School of Physiology, Pharmacology & Neuroscience
Previously thought of as only a support cell for neurons, astrocytes have now been shown to play an essential role in regulating synaptic activity and regulating transmitter uptake and release. Read more
 Supervisors: Prof KW Wilkinson, Dr K McMillan, Dr P Banks
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The genetic map of human molecular phenotypes

University of Bristol Bristol Medical School
Rationale. Genome wide associations studies (GWASs) have discovered many genetic associations with a large range of human traits, but the functional consequences of GWAS signals often remain elusive, as most GWAS signals reside in non-coding genomic regions. Read more
 Supervisors: Dr J Min, Dr G Hemani, Dr JH Hawe
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Identifying DNA methylation signatures of prostate cancer progression and mortality among patients with clinically confirmed, localised disease at baseline in a large prospective clinical trial

University of Bristol Bristol Medical School
Rationale. Prostate Cancer (PCa) is a leading cause of male mortality, with 336,000 deaths worldwide each year (1). Although most PCa cases are indolent, slow-growing, and tend not to progress, a subset of PCa cases are more aggressive and will progress to metastases, treatment resistance and death. Read more
 Supervisors: Dr P Yousefi, Prof R Martin, Dr M Suderman, Dr A Lane, Dr SM Merriel
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Breastfeeding and big babies - lifecourse and genomics epidemiological approaches to disentangle cause and effect.

University of Bristol Bristol Medical School
Rationale. The World Health Organisation recommends exclusively breastfeeding for 6 months, but in the UK, only 1% of infants meet the guidelines (1). Read more
 Supervisors: Dr L Zuccolo, Dr LJ Johnson, Dr L Howe, Dr C Borges
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Identifying causal pathways to disease using DNA methylation predicted blood traits.

University of Bristol Bristol Medical School
Project Background. Blood cell types have been implicated in pathogenesis of chronic diseases. Genome wide association studies have identified thousands of variants associated with blood trait variation. Read more
 Supervisors: Dr J Min, Dr E Hannon, Prof J MIll
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Metabolomic characterisation of adiposity across the life course

University of Bristol Bristol Medical School
Project Background. There is evidence that adiposity, measured by body mass index (BMI), causally influences a range of health outcomes, but little understanding of the mechanisms driving BMI effects. Read more
 Supervisors: Dr L Corbin, Prof N Timpson, Dr RT Tsang
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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