Molecular Biology PhD Research Projects PhD Projects, Programmes & Scholarships in Liverpool

We have 30 Molecular Biology PhD Research Projects PhD Projects, Programmes & Scholarships in Liverpool

Creation of cell lines modelling complex karyotype in B cell lymphomas using CRISPR/Cas9

University of Liverpool Institute of Systems, Molecular and Integrative Biology

Chronic lymphocytic leukaemia (CLL) and diffuse large B cell lymphoma (DLBCL) make up more than half of all the newly diagnosed cases of non-Hodgkin’s lymphoma (NHL), the 6th most common cancer in the UK. Read more

Supervisors: Dr J Slupsky, Dr N Kalakonda, Dr M Glenn

1 May 2024 PhD Research Project Self-Funded PhD Students Only

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Biological pathways supporting the formation and function of chromatin (Scholarship)

University of Liverpool Institute of Systems, Molecular and Integrative Biology

Every cell in our body contains the same DNA yet each cell expresses a different set of genes. These changes in gene expression are heavily influenced by histone proteins, their role in packaging DNA into chromatin and the “epigenetic” information they carry. Read more

Supervisor: Dr CM Hammond

Year round applications PhD Research Project Self-Funded PhD Students Only

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Chromatin regulation of oncogenic transcription and replication stress: mechanism and functional implications in acute myeloid leukemia

University of Liverpool Institute of Systems, Molecular and Integrative Biology

This project focuses on the molecular mechanisms promoting acute myeloid leukaemia (AML), a disease of great unmet need. AML is an aggressive blood and bone marrow cancer characterized by abnormal proliferation and differentiation of myeloid cells. Read more

Supervisors: Dr M Papamichos Chronakis, Prof D MacEwan, Dr A Kanhere

Year round applications PhD Research Project Self-Funded PhD Students Only

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Probing Death Decisions from Morphogen Gradient Fields

University of Liverpool Department of Molecular and Clinical Cancer Medicine

Morphogen gradient scaling is one of the hottest fields in developmental biology at the moment. Scaling is fundamental, explaining how the machinery that controls pattern formation in development (the morphogens) can adapt, so that organs of different sizes show morphological structures which are proportioned. Read more

Supervisor: Dr MM Merino

Year round applications PhD Research Project Self-Funded PhD Students Only

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Improving Photosynthetic Efficiency - Engineering and Evolution of Light-Harvesting Complexes via Synthetic Biology

University of Liverpool Institute of Systems, Molecular and Integrative Biology

Photosynthesis is the ultimate source of food and energy for almost all forms of life. Using sunlight as the energy input, photosynthesis removes carbon dioxide from the atmosphere generating the oxygen and carbohydrate that support complex life. Read more

Supervisor: Dr D Canniffe

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the cellular functions of Trappc9 in brain development and microcephaly

University of Liverpool Institute of Systems, Molecular and Integrative Biology

This PhD project will investigate the cellular functions of the Trafficking protein particle complex subunit 9 (Trappc9) and its roles in brain development. Read more

Supervisors: Dr A Plagge, Dr T Zech

Year round applications PhD Research Project Self-Funded PhD Students Only

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Molecular characterisation of a novel transporter for the atypical antipsychotic clozapine

University of Liverpool Institute of Systems, Molecular and Integrative Biology

Schizophrenia is a severe psychiatric illness affecting about 24 million people worldwide. Schizophrenia can have a devastating effect on a patient’s life and is associated with increased mortality, with life expectancy reduced on average by 15 years compared to that of the general population. Read more

Supervisors: Dr D Dickens, Prof M Pirmohamed

Year round applications PhD Research Project Self-Funded PhD Students Only

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Determining metabolic reprogramming events in stem cells in response to inflammatory disease phenotype

University of Liverpool Institute of Life Course and Medical Sciences

Mesenchymal stem cells (MSCs) are responsible for the repair of damaged tissue following injury and disease as well as moderating innate and adaptive immune responses and regulation of self-tolerance and tissue homeostasis. Read more

Supervisors: Dr R Oldershaw, Dr A Chadwick, Dr M Phelan, Dr BN Norman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Cardiovascular and Neuromuscular Functions around the Clock: Harnessing Protective Endogenous Mechanisms towards Smarter Design of Novel Therapies and Interventions

University of Liverpool Institute of Life Course and Medical Sciences

Optimal tissue and organ is essential for long-term health and quality of life. One such important regulator within the body is related to circadian rhythms, which control ~24h cycles in many physiological processes such as sleep/wake cycles, physical activity/rest cycles, drug metabolism and hormones. Read more

Supervisor: Dr VPV Pekovic-Vaughan

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identifying age-related extracellular microenvironment in dental tissues

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Periodontal disease is the sixth most globally prevalent age-related disease and a leading cause of tooth loss, significantly impacting quality of life and healthy ageing. Read more

Supervisors: Dr K Yamamoto, Prof FJ Jarad

Year round applications PhD Research Project Self-Funded PhD Students Only

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Why do cancers cells re-express meiotic SYCP1 protein?

University of Liverpool Institute of Systems, Molecular and Integrative Biology

The aim of meiosis is to generate gametes by recombining the chromosomes and reducing the genome from diploid to haploid. However, in mitosis haploid genome and recombination have catastrophic, oncogenic outcomes. Read more

Supervisor: Dr U McClurg

Year round applications PhD Research Project Self-Funded PhD Students Only

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Engineering more water-use efficient crops: functional genomics of CO2 fixation during Crassulacean acid metabolism

University of Liverpool Institute of Systems, Molecular and Integrative Biology

The world is getting hotter and drier due to climate change, and the human population is growing rapidly. Furthermore, it has been predicted that we will need to increase crop yields by 50 - 70 % by 2050 in order to feed the predicted 9 - 10 billion people. Read more

Supervisors: Dr J Hartwell, Dr P Walley

Year round applications PhD Research Project Self-Funded PhD Students Only

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Mechanisms controlling gene expression in hypoxia and inflammation

University of Liverpool Institute of Systems, Molecular and Integrative Biology

Oxygen is one of the most important molecules for life. Every member of the animal kingdom depends on oxygen to help metabolize its food and drive many critical processes in metabolism. Read more

Supervisor: Prof S Rocha

Year round applications PhD Research Project Self-Funded PhD Students Only

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Protecting cells from mechanical stress: A novel role of cell-surface receptor LRP1 in extracellular matrix- nuclei communication.

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Cellular adaptation to mechanical strain (mechano-adaptation) is increasingly understood to be conferred by Lamin intermediate filament proteins located within the nuclear lamina. Read more

Supervisor: Dr K Yamamoto

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the impact of galectin-ligand interaction on cancer cell resistance to chemotherapeutic treatment

University of Liverpool Institute of Life Course and Medical Sciences

Galectins are multifunctional carbohydrate-binding proteins that are expressed by many types of human cells. Changes of galectin expression commonly occur in cancer (e.g. Read more

Supervisor: Prof LG Yu

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 30 Molecular Biology PhD Research Projects PhD Projects, Programmes & Scholarships in Liverpool

Molecular Biology PhD Research Projects PhD Projects, Programmes & Scholarships in Liverpool

We have 30 Molecular Biology PhD Research Projects PhD Projects, Programmes & Scholarships in Liverpool

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