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We have 23 University of Sheffield Molecular Biology PhD Projects, Programmes & Scholarships

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University of Sheffield Molecular Biology PhD Projects, Programmes & Scholarships

We have 23 University of Sheffield Molecular Biology PhD Projects, Programmes & Scholarships

University of Sheffield

Our University has a reputation for world-class teaching and research excellence across a variety of disciplines

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Untangling how Shelterin safeguards telomere structure and stability - one molecule at a time

University of Sheffield School of Biosciences
Background. Telomeres solve two problems with linear chromosomes. the end-replication problem, DNA loss from the end of chromosomes every replication cycle; and the end-protection problem, protection of the chromosome ends to prevent chromosome fusions. Read more
 Supervisors: Dr M Newton, Dr A Pyne
 3 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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How does glycolysis influence the oral environment during caries and periodontitis?

University of Sheffield School of Clinical Dentistry
Glycolysis plays a pivotal role during energy metabolism and cellular responses in oral health and pathology. It is a crucial metabolic pathway for energy production, especially in inflammation or infection scenario, that is essential for maintaining tissue integrity and function in the gingiva and dental pulp. Read more
 Supervisors: Dr C M Neves, Prof G Stafford
 31 May 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Precision Therapy for NBAS-related disorder

University of Sheffield School of Medicine and Population Health
It is very well recognised that rare diseases offer the potential to uncover new information about mechanisms underlying a range of phenotypes. Read more
 Supervisor: Dr M Balasubramanian
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Role of primary cilia in skeletal muscle stem cells and muscle regeneration

University of Sheffield School of Biosciences
Primary cilia are cellular organelles present at the surface of many cell types in vertebrates. In recent years, they have been shown to play essential roles in relaying signalling information from the environment to the cell. Read more
 Supervisor: Dr A G Borycki
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Control of skeletal muscle regeneration and aging by cell signalling

University of Sheffield School of Biosciences
The ability of skeletal muscles to regenerate in response to injury, exercise, growth or disease depends on a population of adult skeletal muscle stem cells. Read more
 Supervisor: Dr A G Borycki
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Genomic and Proteomics-Based Characterisation of Microalgal Cell Factories

University of Sheffield Department of Chemical & Biological Engineering
Microalgae have generated increasing interest as microbial cell factories to produce proteins, pigments, therapeutics, and nutraceuticals. Read more
 Supervisors: Dr J Pandhal, Prof MJ Dickman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Glycosylation in Microalgal Host Cells

University of Sheffield Department of Chemical & Biological Engineering
Microalgae have generated increasing interest as microbial cell factories to produce therapeutics proteins. This is because they can grow on very cheap media and their GRAS (generally regarded as safe) status means they are a fantastic option for the production of therapeutics that can be administered orally. Read more
 Supervisors: Dr J Pandhal, Dr C Evans
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Engineering Virus-Like Particles for Next-Generation Vaccine Manufacturing

University of Sheffield Department of Chemical & Biological Engineering
Virus-like particles (VLPs) are structures typically composed of viral structural proteins that self-assemble into virus-like structures. Read more
 Supervisors: Dr K Tee, Prof TS Wong, Dr C Evans
 30 April 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Exploring Uncharted Territories: Investigating the Impact of Follicular Fluid Extracellular Vesicles on Spermatozoa Function

University of Sheffield School of Medicine and Population Health
The intricate dynamics underlying successful mammalian reproduction continue to captivate scientific inquiry. However, the mechanisms governing the interaction between spermatozoa and the female reproductive tract remain elusive. Read more
 Supervisor: Prof A Fazeli
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Effect of androgens on preantral follicle development

University of Sheffield School of Medicine and Population Health
Polycystic ovary syndrome (PCOS) is a condition that affects >5% of women of reproductive age and is the most common cause of menstrual dysfunction and is associated with metabolic abnormalities and increased risk to long-term health. Read more
 Supervisors: Dr M Fenwick, Dr N Krone
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Antisense technologies as potential treatments for Cushing’s disease

University of Sheffield School of Medicine and Population Health
Cushing’s disease is a devastating condition caused by a pituitary corticotroph tumour that over-expresses the proopiomelanocortin gene (POMC) and secretes high levels of ACTH. Read more
 Supervisor: Dr E H Kemp
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The analysis of HIF function in DNA repair and genome stability

University of Sheffield School of Biosciences
DNA damage is a factor that underlies many human diseases. Such damage results in mutations, and if such genetic alterations occur in tumour suppressor or proto-oncogenes it can lead to cancer. Read more
 Supervisors: Dr F Van Eeden, Prof S El-Khamisy
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Molecular characterisation of scavenger receptor ligand binding.

University of Sheffield School of Biosciences
Scavenger receptors have been identified as being important in Human disease and normal physiological responses. Scavenger receptors are a large family of cell surface receptors that are expressed ubiquitously. Read more
 Supervisors: Dr S Brown, Dr I Evans
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The regulation of scavenger receptors in cancer

University of Sheffield School of Biosciences
The expression of some scavenger receptors has been identified as being poor for cancer prognosis. Scavenger receptors are a large family of cell surface receptors that are expressed ubiquitously in the Human body. Read more
 Supervisors: Dr S Brown, Dr C Guo
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Identification of the molecular pathways that guide tissue regeneration

University of Sheffield School of Biosciences
The study of regenerative biology aims to elucidate the innate ability of organisms to replace tissues or organs after they have been removed or damaged. Read more
 Supervisor: Dr H Roehl
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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