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We have 16 Molecular Biology (assessment) PhD Projects, Programmes & Scholarships

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Molecular Biology (assessment) PhD Projects, Programmes & Scholarships

We have 16 Molecular Biology (assessment) PhD Projects, Programmes & Scholarships

NIHR Leeds BRC: An interferon diagnostic to inform early detection and prevention strategies in Ana positive CTDs

Type I interferons (IFN) play a role in a wide range of rheumatic and musculoskeletal diseases (RMDs), and strong evidence suggests that measurement of IFN activity could have clinical value, although testing has not progressed into clinical settings. Read more

Application and development of bioinformatics and network theory methods in cardiovascular disease research and pharmacovigilance

To be able to discover novel drug targets we aim to develop software based on network theoretic approaches that are capable to identify mediators and pathways involved in the pathomechanism of various cardiovascular diseases by the analysis of datasets assessed with high throughput molecular biological techniques (e.g. Read more

Membrane protein-metabolite interactions important in mitochondrial energy metabolism for burning fat as heat (CRICHTON_U24DTP)

Primary supervisor - Dr Paul Crichton . Secondary supervisor - Prof. Tom Clarke (UEA) . Mitochondria in our cells harness energy through the breakdown of nutrients to produce ATP through oxidative phosphorylation. Read more

Cardiovascular and Neuromuscular Functions around the Clock: Harnessing Protective Endogenous Mechanisms towards Smarter Design of Novel Therapies and Interventions

Optimal tissue and organ is essential for long-term health and quality of life. One such important regulator within the body is related to circadian rhythms, which control ~24h cycles in many physiological processes such as sleep/wake cycles, physical activity/rest cycles, drug metabolism and hormones. Read more

Control of bone shape and function by the extracellular matrix Fibrillin-1

Bones are tightly regulated structures that remodel their structure to adapt to changes in their mechanical environment. With ageing, this mechanical response is often dampened, leading to bone loss and weakness. Read more

Genetics: Investigating the functional effect of novel genes and genetic variants in malignant hyperthermia susceptibility using model systems

Malignant hyperthermia (MH) is an inherited condition, where patients exposed to anaesthetic drugs are susceptible to a dramatic hyperthermic and hypermetabolic response that can contribute to a significant proportion of post-operative morbidity and deaths. Read more

Biomechanical signalling in human heart disease

About the Project. The human heart undergoes more than 2 billion beats throughout an individual's lifetime, with its rhythm precisely regulated by signalling events that continuously adapt to the biomechanical stress exerted on the ventricular walls. Read more

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