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We have 29 Molecular Biology (drug design) PhD Projects, Programmes & Scholarships

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Molecular Biology (drug design) PhD Projects, Programmes & Scholarships

We have 29 Molecular Biology (drug design) PhD Projects, Programmes & Scholarships

The development of new antiviral agents targeting HIV-1

Even before the current global COVID-19 pandemic, the threat posed to human health by viruses was extensive and although significant progress in targeting some viruses (e.g., HIV-1 and hepatitis C) has been made, challenges remain. Read more

Control and inhibition of virus replication

The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specifically Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets. Read more

Exploring Viral Nucleic Acid Machinery via Cryo Electron Microscopy to Advance Biomedicine

Viruses, these tiny but potent life forms, are all around us, infecting various organisms and directly affecting human health. Although in most cases, viral infection is not life threatening, in the minority of cases it leads to long-term disorders including cancer. Read more

Fully funded PhD studentship in mechanisms of cancer heterogeneity and drug sensitivity

Treatment of cancer with drugs that cause DNA damage often leads to development of the drug tolerance. Recently, we uncovered a novel mechanism of such an adaptation that associates with active generation of hundreds of thousand mutations in chromosomes that prevent drug-triggered DNA damage. Read more

Cardiovascular and Neuromuscular Functions around the Clock: Harnessing Protective Endogenous Mechanisms towards Smarter Design of Novel Therapies and Interventions

Optimal tissue and organ is essential for long-term health and quality of life. One such important regulator within the body is related to circadian rhythms, which control ~24h cycles in many physiological processes such as sleep/wake cycles, physical activity/rest cycles, drug metabolism and hormones. Read more

Understanding Hormone Regulation in Skin Cancer Development and Progression

Skin cancers, including melanoma and non-melanoma skin cancers, pose a significant global health burden. While the role of hormones in skin cancer development and progression remains an underexplored area, recent research has suggested potential links between hormonal regulation and skin cancer outcomes. Read more

The role of GLUT transporters in microglial metabolism, investigating functionality, regulation and drug targetable properties.

Modifying the brain’s metabolism as an intervention or for the treatment of Alzheimer’s disease represents a novel strategy for targeting what is recognised as a multifactorial condition which lacks effective therapeutic options.   . Read more

Understanding interactions of proteins with polymer-coated nanoparticles

Introduction. Polymer-coated nanoparticles are promising drug delivery vehicles. Multiple functionalities can be embedded into the nanoparticle structure to enable uptake of the drug-like molecules, their targeted delivery and controlled release. Read more

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