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We have 24 Molecular Biology (enzyme) PhD Projects, Programmes & Scholarships

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Molecular Biology (enzyme) PhD Projects, Programmes & Scholarships

We have 24 Molecular Biology (enzyme) PhD Projects, Programmes & Scholarships

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Enzyme Cascades controlled in the Electrochemical Leaf for Discovery in Antimicrobial Strategy

The University of Manchester Department of Chemistry
Antibiotic discovery is usually aimed at single entities, for example a bacterial enzyme or efflux protein. This also means that antimicrobial resistance (AMR) mechanisms are considered in terms of the individual response, for example, mutations in a single target enzyme, affording resistance to the drug. Read more
 Supervisor: Dr C Megarity
 30 April 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Sustainable Commodity Chemicals through Enzyme Engineering & Design (SuCCEED) - 4 posts available

The University of Manchester Department of Chemistry
SuCCEED is a BBSRC-funded Prosperity Partnership multi-million project between The University of Manchester and Shell. Commodity chemicals are produced on a global scale and normally derived from finite geological sources. Read more
 Supervisors: Dr N Dixon, Dr J Esteban Serrano, Prof A Green, Prof D Leys, Dr V Spallina, Prof M Turner, Dr J Winterburn
 30 June 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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Structure and function of enzyme complexes involved in post-transcriptional gene regulation

University of Nottingham School of Pharmacy
Many proteins in human cells function as part of high molecular weight multi-subunit assemblies. The structure and function of such large molecular machines is often difficult to characterise due to their complexity, low abundance and structural dynamics. Read more
 Supervisor: Dr G S Winkler
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the Roles for deSUMOylation Enzyme SENP3 in Autophagy Impaired by α-synuclein

University of Sheffield School of Biosciences
Aggregation of α-synuclein protein in neuronal cells has been strongly implicated in the pathogenesis of neurodegenerative disorders (Synucleinopathies) including Parkinson's disease and dementia with Lewy bodies. Read more
 Supervisor: Dr C Guo
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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(MRC DTP CASE) Prediction of substrate binding geometry and strength in promiscuous enzymes: computational chemistry applicable to the design of pharmaceuticals and agrochemicals

The University of Manchester Faculty of Biology, Medicine and Health
We are often taught about the power of enzymes to select particular substrates from the biological milieu and of their ability to perform highly selective reactions on those substrates. Read more
 Supervisors: Dr A Leach, Dr S De Visser, Dr C Trujillo
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Discovery and profiling of small-molecule inhibitors of cellular nuclease enzymes

University of Nottingham School of Pharmacy
Nuclease enzymes are non-traditional drug targets that attract an increasing amount of interest as potential targets relevant for a variety of therapeutic areas including infection, cancer and bone disease. Read more
 Supervisor: Dr G S Winkler
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Regulation of CaaX protein processing

Queen’s University Belfast School of Pharmacy
USP17 is over-expressed in a range of primary tumours including NSCLC, breast, colorectal, cervical, ovarian and osteosarcoma and its depletion has been shown to block the growth of cells from all these cancer types, as well as the migration of a range of cancer cells (NSCLC, breast, ovarian, osteosarcoma).    . Read more
 Supervisor: Dr J Burrows
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Natural products in bacterial physiology and chemical interaction

University of Leicester Department of Genetics and Genome Biology
Microbial natural products have diverse chemical structures and bioactivities, which range from cell-cell signalling, nutrient acquisition, antifungal and antibacterial activity to stress resistance (1). Read more
 Supervisors: Dr C Jenul, Prof D Jones
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Molecular level understanding of Mycobacterium tuberculosis

University of Leicester Department of Respiratory Sciences
Mycobacterium tuberculosis has evolved to survive and replicate inside macrophages. The project will investigate the molecular mechanisms underpinning adaptation to this specialised intracellular niche. Read more
 Supervisors: Dr H O'Hare, Dr N Garton
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Self-funded PhD- Understanding the molecular mechanism of a bacterial genome defence system and its synergy with CRISPR-Cas

University of Bristol School of Biochemistry
Prokaryotes have evolved over billions of years alongside their viruses, the bacteriophages, or “phages”. To prevent viral infection, prokaryotes have evolved rudimentary immune mechanisms, the most widespread and well-studied of which are the Restriction-Modification and the CRISPR-Cas enzymes. Read more
 Supervisor: Prof M D Szczelkun
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Self funded MSc by research or PhD in Biology: Discovery, evolution and applications in plant natural product biosynthesis

University of York Department of Biology
Lead supervisor: . The student will be registered with the Department of Biology. Plants are capable of producing complex molecules for defense and adaptation. Read more
 Supervisor: Dr B R Lichman
 30 June 2024  PhD Research Project  Self-Funded PhD Students Only
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Novel glycoprotease discovery and characterisation for enhanced detergent performance

Newcastle University BiSCoP CTP
In this exciting joint academia-industry project the student will exploit metagenomes and the huge untapped capacity of the human gut microbiota to breakdown glycoconjugates to discover novel protease enzymes that can potentially increase the performance and environmental sustainability of leading P&G automatic dishwashing brands. Read more
 Supervisors: Dr E Lowe, Dr D Bolam, Dr AL Morales Garcia, Mrs K Bell-Rusiewicz
 2 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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BOOSTING C4 PHOTOSYNTHESIS BY ALTERING PEP CARBOXYLASE

Western Sydney University Hawkesbury Institute for the Environment
ABOUT THE PROJECT. The Hawkesbury Institute for the Environment (HIE) is offering a research scholarship to a highly motivated PhD candidate to work within a research group addressing how to improve the primary carboxylase of C4 photosynthesis. Read more
 Supervisor: Dr RS Sharwood
 30 April 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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‘Payload-Releasing Electrophiles’ – a new disease-selective delivery strategy for diagnostics and therapeutics

University of Leicester Department of Chemistry
Graduate Teaching Assistantship. This is a Graduate Training Assistantship (GTA), which means that you will be required to do some teaching, particularly lab demonstrating, as part of your training. Read more
 Supervisors: Dr R Hopkinson, Dr K Tanaka
 22 April 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Chemical energy conversion in biology studied using advanced spectroscopic and structural tools

University of Leicester Department of Chemistry
Graduate Teaching Assistantship. This is a Graduate Training Assistantship (GTA), which means that you will be required to do some teaching, particularly lab demonstrating, as part of your training. Read more
 Supervisor: Dr P Ash
 22 April 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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