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We have 31 Molecular Biology (liverpool) PhD Projects, Programmes & Scholarships

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Molecular Biology (liverpool) PhD Projects, Programmes & Scholarships

We have 31 Molecular Biology (liverpool) PhD Projects, Programmes & Scholarships

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Biological pathways supporting the formation and function of chromatin (Scholarship)

University of Liverpool Institute of Systems, Molecular and Integrative Biology
Every cell in our body contains the same DNA yet each cell expresses a different set of genes. These changes in gene expression are heavily influenced by histone proteins, their role in packaging DNA into chromatin and the “epigenetic” information they carry. Read more
 Supervisor: Dr CM Hammond
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Determination of the non-coding RNAs in the knee joint tissues of dogs at differing risk to cranial cruciate ligament rupture.

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Background. The cranial cruciate ligment (CCL) is the most frequently damaged ligament of the canine knee joint following injuries and age-related ligament breakdown, leading to the development of osteoarthritis (OA). Read more
 Supervisors: Prof E Comerford, Prof M Peffers
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Creation of cell lines modelling complex karyotype in B cell lymphomas using CRISPR/Cas9

University of Liverpool Institute of Systems, Molecular and Integrative Biology
Chronic lymphocytic leukaemia (CLL) and diffuse large B cell lymphoma (DLBCL) make up more than half of all the newly diagnosed cases of non-Hodgkin’s lymphoma (NHL), the 6th most common cancer in the UK. Read more
 Supervisors: Dr J Slupsky, Dr N Kalakonda, Dr M Glenn
 1 May 2024  PhD Research Project  Self-Funded PhD Students Only
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Gaining mechanistic insights into Atrial Fibrillation: Bench to bedside approaches

University of Liverpool Department of Pharmacology and Therapeutics
Atrial fibrillation (AF) is a common arrhythmia with symptoms like irregular heart rate, palpitations, shortness of breath, tiredness, and dizziness. Read more
 Supervisor: Dr RB Burton
 1 July 2024  PhD Research Project  Self-Funded PhD Students Only
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Study of early pathological changes in calcified cartilage in osteoarthritis and alkaptonuria

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
We are seeking a motivated individual to work on this exciting project investigating the role that the calcified cartilage has in rare and common joint osteoarthritis, using novel approaches such as gene silencing and establishment of a 3D chondrocyte cell culture model. Read more
 Supervisor: Dr JH Hughes
 10 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Why do cancers cells re-express meiotic SYCP1 protein?

University of Liverpool Institute of Systems, Molecular and Integrative Biology
The aim of meiosis is to generate gametes by recombining the chromosomes and reducing the genome from diploid to haploid. However, in mitosis haploid genome and recombination have catastrophic, oncogenic outcomes. Read more
 Supervisor: Dr U McClurg
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cardiovascular and Neuromuscular Functions around the Clock: Harnessing Protective Endogenous Mechanisms towards Smarter Design of Novel Therapies and Interventions

University of Liverpool Institute of Life Course and Medical Sciences
Optimal tissue and organ is essential for long-term health and quality of life. One such important regulator within the body is related to circadian rhythms, which control ~24h cycles in many physiological processes such as sleep/wake cycles, physical activity/rest cycles, drug metabolism and hormones. Read more
 Supervisor: Dr VPV Pekovic-Vaughan
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Chromatin regulation of oncogenic transcription and replication stress: mechanism and functional implications in acute myeloid leukemia

University of Liverpool Institute of Systems, Molecular and Integrative Biology
This project focuses on the molecular mechanisms promoting acute myeloid leukaemia (AML), a disease of great unmet need. AML is an aggressive blood and bone marrow cancer characterized by abnormal proliferation and differentiation of myeloid cells. Read more
 Supervisors: Dr M Papamichos Chronakis, Prof D MacEwan, Dr A Kanhere
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Improving Photosynthetic Efficiency - Engineering and Evolution of Light-Harvesting Complexes via Synthetic Biology

University of Liverpool Institute of Systems, Molecular and Integrative Biology
Photosynthesis is the ultimate source of food and energy for almost all forms of life. Using sunlight as the energy input, photosynthesis removes carbon dioxide from the atmosphere generating the oxygen and carbohydrate that support complex life. Read more
 Supervisor: Dr D Canniffe
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the role of oxidative metabolites in joint destruction in osteoarthritis

University of Liverpool Institute of Life Course and Medical Sciences
We are seeking a motivated researcher to work on a pioneering project investigating the role of oxidative stress in alkaptonuria (AKU) and associated conditions. Read more
 Supervisors: Dr BN Norman, Dr JH Hughes, Prof G Bou-Gharios
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Molecular characterisation of a novel transporter for the atypical antipsychotic clozapine

University of Liverpool Institute of Systems, Molecular and Integrative Biology
Schizophrenia is a severe psychiatric illness affecting about 24 million people worldwide. Schizophrenia can have a devastating effect on a patient’s life and is associated with increased mortality, with life expectancy reduced on average by 15 years compared to that of the general population. Read more
 Supervisors: Dr D Dickens, Prof M Pirmohamed
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Engineering polysaccharide sulfotransferases

University of Liverpool Institute of Systems, Molecular and Integrative Biology
The ENZACT Prosperity Partnership is led by UCL and brings together five Universities and two major MNCs. The Liverpool component of ENZACT is focussed on enzymatic sulfation. Read more
 Supervisors: Prof D G Fernig, Dr E A Yates, Dr IB Barsukov
 14 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Probing Death Decisions from Morphogen Gradient Fields

University of Liverpool Department of Molecular and Clinical Cancer Medicine
Morphogen gradient scaling is one of the hottest fields in developmental biology at the moment. Scaling is fundamental, explaining how the machinery that controls pattern formation in development (the morphogens) can adapt, so that organs of different sizes show morphological structures which are proportioned. Read more
 Supervisor: Dr MM Merino
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Protecting cells from mechanical stress: A novel role of cell-surface receptor LRP1 in extracellular matrix- nuclei communication.

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology
Cellular adaptation to mechanical strain (mechano-adaptation) is increasingly understood to be conferred by Lamin intermediate filament proteins located within the nuclear lamina. Read more
 Supervisor: Dr K Yamamoto
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating the impact of galectin-ligand interaction on cancer cell resistance to chemotherapeutic treatment

University of Liverpool Institute of Life Course and Medical Sciences
Galectins are multifunctional carbohydrate-binding proteins that are expressed by many types of human cells. Changes of galectin expression commonly occur in cancer (e.g. Read more
 Supervisor: Prof LG Yu
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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