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MRC & Asthma UK Centre in Allergic Mechanisms of Asthma

PhD Studentships in Allergic Mechanisms of Asthma

The MRC-Asthma UK Centre in Allergic Mechanisms of Asthma is a partnership between the Medical Research Council, Asthma UK, Imperial College London, King’s College London and partner NHS Trusts to advance our understanding of the pathogenesis of asthma. This provides an outstanding opportunity for high-calibre PhD students to train in areas of basic and clinical science that have direct relevance to the development of novel approaches for the prevention and treatment of asthma.

MRC & Asthma UK Centre in Allergic Mechanisms of Asthma

Applications are now invited for PhD studentships (1yr plus 3-yr) to start in October 2017. In their first year, successful students will undertake either a one year full-time MSc in Immunology at King's College London, obtaining a foundation in cellular, molecular and clinical immunology and including a 6-month laboratory-based research project within the Centre; or a MRes in Biomedical Research at Imperial College London, including two 6-month laboratory based research projects.

Following the successful completion of the first year, students will be able to choose from a broad range of PhD projects based at Imperial College London or King’s College London covering the various interests of the centre, examples of some of the projects offered are listed below:

  • Environmental exposure, asthma and the pulmonary complications of sickle cell disease
  • TRPM3 a key driver of bronchospasm and cough
  • Evaluation of Immune mechanisms of novel house dust mite immunotherapy approach in allergic asthmatics
  • Investigating the role of platelet during sensitization to allergen
  • The interplay between innate and adaptive immunity in the inception of asthma in early life
  • Mitochondrial oxidative and nitrative stress in eosinophilic asthma
  • Molecular mechanisms of IgE network interactions in regulating allergic responses
  • A statistical causal modelling approach to understanding the developmental profiles of asthma and allergy
  • Deep sequencing of antibody repertoires in allergic diseases and asthma
  • Single-molecule imaging of the IgE B cell receptor
  • Understanding treatable traits using the U-BIOPRED cohort
  • Interleukin 35, a key player in tolerance induction following successful Allergen Immunotherapy
  • Mechanisms mediating viral induced wheezing and factors determining progression to severe childhood asthma Structure and functions of the long and short forms of membrane IgE in the IgE B cell receptor
  • Antimicrobial peptides in severe asthma
  • Molecular mechanisms underlying mast cell progenitor recruitment
  • Identification of novel factors regulating class switching to IgE in human B cells
  • Functional dissection of GSDMB domains and its potential roles in airway inflammation
  • The impact of vitamin D deficiency on asthma-related immune responses in early life
  • Identification of proteins that regulate ORMDL3 in epithelial inflammation
  • Regulation of ILC2 by Allergen Immunotherapy
  • Structure and functions of the long and short forms of membrane IgE in the IgE B cell receptor
  • Chemokine Biology in Asthma Pathogenesis
  • Epithelial-macrophage interactions driving pulmonary inflammation
  • Understanding the influence of glucocorticoids upon the epigenome
  • Targeting biased signalling pathways of purinergic receptors to supress inflammation
  • Approaches to the study of IgE antibody B cell generation and trafficking in the allergic response
  • Th17 biology in severe asthma
  • Pathogen sensing by nerves is a key driver of respiratory symptoms
  • Asthma Triggers and Sensory Irritation in the Airway: Contribution to the non-TH2 Asthma Phenotype

Advertised studentships are predominantly restricted to home or EU candidates based on the nature of the funding. Students from outside the EU area would be required to pay substantially higher tuition fees that would not be covered by these studentship awards.

MRC & Asthma UK Centre in Allergic Mechanisms of Asthma

How to Apply

Applicants must be in receipt of, or due to receive, a first or upper second-class UK degree or equivalent in an appropriate subject.

To apply, send your CV, names of two referees and a one page personal statement to Jana Pierron at [email protected]

Closing date for the full application is Sunday 2nd April 2017. All successful applicants will be contacted in mid-April and invited for interviews in April/May 2017.

Please note that all candidates must fulfil College admissions criteria.

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