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MRC & Asthma UK Centre in Allergic Mechanisms of Asthma

PhD Studentships in Allergic Mechanisms of Asthma

The MRC-Asthma UK Centre in Allergic Mechanisms of Asthma is a partnership between the Medical Research Council, Asthma UK, Imperial College London, King’s College London and partner NHS Trusts to advance our understanding of the pathogenesis of asthma. This provides an outstanding opportunity for high-calibre PhD students to train in areas of basic and clinical science that have direct relevance to the development of novel approaches for the prevention and treatment of asthma.

MRC & Asthma UK Centre in Allergic Mechanisms of Asthma

Applications are now invited for PhD studentships (1yr plus 3-yr) to start in October 2016. In their first year, successful students will undertake a 1 year MRes in Biomedical Research at Imperial College London, including two 6-month laboratory based research projects. There is also the opportunity to do an MRes in Molecular Biophysics at Kings. Following the successful completion of the first year, students will be able to choose from a broad range of PhD projects based at Imperial College London or King’s College London covering the various interests of the centre, examples of some of the projects offered are listed below:

  • Molecular mechanisms of IgE network interactions in regulating allergic responses
  • Deep sequencing of antibody repertoires in allergic diseases and asthma
  • What signals mediate recruitment and activity of innate lymphoid cells within the lung during inflammatory reactions?
  • Characterisation of mucosal IL-25 receptor+TH2 cell clonotypes and biomarkers of disease and treatment response in eosinophilic nasal polyposis
  • Molecular mechanisms underlying leukocyte recruitment to the airways
  • Identification of novel factors regulating class switching to IgE in human B cells
  • Epigenetic priming of airway epithelial inflammatory responses by Th2 cytokines
  • Eosinophil activation and asthma: better biomarkers and new therapies
  • The interplay between innate and adaptive immunity in allergic asthma
  • How does maternal obesity lead to asthma during childhood?
  • Interactions between innate and adaptive immune pathways during pulmonary allergic responses Gene-environment interactions mediating mechanisms underlying development of preschool wheeze
  • Molecular mechanisms underlying the impact of urban particulate matter (pollution) on airway cell function and asthma exacerbations
  • Leukotriene receptors in asthma pathogenesis
  • Study of epigenetic alteration in asthmatic bronchial epithelial cells
  • Understanding the influence of glucocorticoids upon the epigenome
  • Environmental exposure, asthma and the pulmonary complications of sickle cell disease
  • The regulation of airway epithelial inflammation by ORMDL3 and GSDMB
  • Good vs. Evil. The genomics of pathogen and commensal interactions with airway epithelial cells
  • The impact of vitamin D deficiency in utero on chronic respiratory morbidity in prematurely born children and asthma risk
  • Th17 biology in severe asthma
  • Epithelial-immune interactions in the development of allergic lung disease
  • Immunoregulation of viral lung disease
  • Rhinovirus infection and allergen interaction in the pathogenesis of asthma exacerbations
  • Immunological studies of allergen immunotherapy
  • Calcium sensing receptors as novel targets in severe asthma

Advertised studentships are predominantly restricted to home or EU candidates based on the nature of the funding. Students from outside the EU area would be required to pay substantially higher tuition fees that would not be covered by these studentship awards.

How to Apply

MRC & Asthma UK Centre in Allergic Mechanisms of Asthma

Applicants must be in receipt of, or due to receive, a first or upper second-class UK degree or equivalent in an appropriate subject.

To apply you must submit your application, through the College application system, to the MRes Biomedical Research RCVS Stream you must include a one page personal statement with your application and state that you are applying for the MRes/PhD scheme. You should indicate in the application funding fields that you wish to apply for the Asthma UK Centre Studentship.

Application closing date is noon 6th April 2016.

Please note that candidates must fulfil College admissions criteria.


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